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5WHK

Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M

Functional Information from GO Data
ChainGOidnamespacecontents
B0006955biological_processimmune response
B0042612cellular_componentMHC class I protein complex
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue EDO H 301
ChainResidue
HPHE27
HTYR32
HARG98
HHOH414
HHOH422

site_idAC2
Number of Residues7
Detailsbinding site for residue NHE A 301
ChainResidue
BGLY43
BARG45
BILE92
ASER40
AGLU72
AHOH401
AHOH430

site_idAC3
Number of Residues7
Detailsbinding site for residue NHE A 302
ChainResidue
ATYR9
ALYS63
AGLU64
AASP67
ALEU68
APHE154
AARG162

site_idAC4
Number of Residues5
Detailsbinding site for residue EDO A 303
ChainResidue
APHE79
AGLY83
AGLY84
ALYS85
AHOH418

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR197-HIS203
ATYR250-HIS256
BTYR78-HIS84
LTYR195-HIS201

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
ChainResidueDetails
BGLN2

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
ChainResidueDetails
BILE1

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
BLYS19
BLYS41
BLYS48
BLYS58
BLYS91
BLYS94

227561

PDB entries from 2024-11-20

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