7AY0
 
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7AY2
 | | Crystal structure of truncated USP1-UAF1 reacted with ubiquitin-prg | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ... | | 著者 | Arkinson, C, Rennie, M.L, Walden, H. | | 登録日 | 2020-11-10 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
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7AY1
 | | Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI | | 分子名称: | DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... | | 著者 | Rennie, M.L, Arkinson, C, Walden, H. | | 登録日 | 2020-11-10 | | 公開日 | 2021-03-24 | | 最終更新日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
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5NGZ
 | | Ube2T in complex with fragment EM04 | | 分子名称: | 1-(1,3-benzothiazol-2-yl)methanamine, Ubiquitin-conjugating enzyme E2 T | | 著者 | Morreale, F.E, Bortoluzzi, A, Chaugule, V.K, Arkinson, C, Walden, H, Ciulli, A. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
J. Med. Chem., 60, 2017
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6R75
 | | Crystal structure of human Ube2T E54R mutant | | 分子名称: | Ubiquitin-conjugating enzyme E2 T | | 著者 | Chaugule, V.K, Rennie, M.L, Walden, H, Arkinson, C, Kamarainen, O, Toth, R. | | 登録日 | 2019-03-28 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Allosteric mechanism for site-specific ubiquitination of FANCD2.
Nat.Chem.Biol., 16, 2020
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7ZF1
 | | Structure of ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA | | 分子名称: | DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... | | 著者 | Lemonidis, K, Rennie, M.L, Arkinson, C, Streetley, J, Clarke, M, Chaugule, V.K, Walden, H. | | 登録日 | 2022-03-31 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.
Embo J., 42, 2023
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8VSI
 | | Mechanistic Insights Revealed by YbtPQ in the Occluded State | | 分子名称: | ABC transporter ATP-binding protein, ADP ORTHOVANADATE, MAGNESIUM ION, ... | | 著者 | Hu, W, Parkinson, C, Zheng, H. | | 登録日 | 2024-01-24 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanistic Insights Revealed by YbtPQ in the Occluded State.
Biomolecules, 14, 2024
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7ZH4
 | | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ... | | 著者 | Rennie, M.L, Walden, H. | | 登録日 | 2022-04-05 | | 公開日 | 2022-10-12 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
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8A9J
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7ZH3
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8A9K
 | | Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ... | | 著者 | Rennie, M.L, Walden, H. | | 登録日 | 2022-06-28 | | 公開日 | 2022-10-12 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
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