5LSG
 
 | | PPARgamma complex with the betulinic acid | | 分子名称: | Betulinic Acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Calleri, E, Paiardini, A. | | 登録日 | 2016-08-26 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Betulinic acid is a PPAR gamma antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.
Sci Rep, 7, 2017
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3RBL
 | | Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form | | 分子名称: | CHLORIDE ION, aromatic L-amino acid decarboxylase | | 著者 | Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F. | | 登録日 | 2011-03-29 | | 公開日 | 2011-10-19 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | | 主引用文献 | Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RCH
 | | Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the open conformation with LLP and PLP bound to Chain-A and Chain-B respectively | | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, aromatic L-amino acid decarboxylase | | 著者 | Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F. | | 登録日 | 2011-03-31 | | 公開日 | 2011-10-19 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RBF
 | | Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form | | 分子名称: | Aromatic-L-amino-acid decarboxylase, CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F. | | 登録日 | 2011-03-29 | | 公開日 | 2011-10-19 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
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8A11
 | | Cryo-EM structure of the Human SHMT1-RNA complex | | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, cytosolic | | 著者 | Spizzichino, S, Marabelli, C, Bharadwaj, A, Jakobi, A.J, Chaves-Sanjuan, A, Giardina, G, Bolognesi, M, Cutruzzola, F. | | 登録日 | 2022-05-30 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
Mol.Cell, 2024
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6XVW
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6FL5
 | | Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution | | 分子名称: | CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, ... | | 著者 | Giardina, G, Cutruzzola, F, Lucchi, R. | | 登録日 | 2018-01-25 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
FEBS J., 285, 2018
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6T9C
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5OFY
 | | Crystal structure of the D183N variant of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at pH 9.0. 2.8 Ang; internal aldimine with PLP in the active site | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase | | 著者 | Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R. | | 登録日 | 2017-07-11 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
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5OG0
 | | Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 2.5 Angstrom; internal aldimine with PLP in the active site | | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase | | 著者 | Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R. | | 登録日 | 2017-07-11 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
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8R7H
 | | Cryo-EM structure of Human SHMT1 | | 分子名称: | Serine hydroxymethyltransferase, cytosolic | | 著者 | Spizzichino, S, Marabelli, C, Bharadwaj, A, Jakobi, A.J, Chaves-Sanjuan, A, Giardina, G, Bolognesi, M, Cutruzzola, F. | | 登録日 | 2023-11-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
Mol.Cell, 84, 2024
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7A7E
 | | Structure of a delta-N mutant - E232start - of PA1120 (TpbB or YfiN) from Pseudomonas aeruginosa (PAO1) comprising only the GGDEF domain | | 分子名称: | Diguanylate cyclase TpbB, MAGNESIUM ION | | 著者 | Giardina, G, Rinaldo, S, Mantoni, F, Brunotti, P. | | 登録日 | 2020-08-28 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts.
Life, 11, 2021
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8QYT
 | | Human Pyridoxine-5'-phosphate oxidase in complex with PLP | | 分子名称: | BETA-MERCAPTOETHANOL, FLAVIN MONONUCLEOTIDE, PYRIDOXAL-5'-PHOSPHATE, ... | | 著者 | Antonelli, L, Ilari, A, Fiorillo, A. | | 登録日 | 2023-10-26 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Identification of the pyridoxal 5'-phosphate allosteric site in human pyridox(am)ine 5'-phosphate oxidase.
Protein Sci., 33, 2024
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8QYW
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5CBM
 | | Crystal structure of PfA-M17 with virtual ligand inhibitor | | 分子名称: | (2S)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, CARBONATE ION, GLYCEROL, ... | | 著者 | Ruggeri, C, Drinkwater, N, McGowan, S. | | 登録日 | 2015-07-01 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Plos One, 10, 2015
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6HX7
 | | Crystal structure of human R180T variant of ORNITHINE AMINOTRANSFERASE at 1.8 Angstrom | | 分子名称: | Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Giardina, G, Montioli, R, Cellini, B, Cutruzzola, F, Borri Voltattorni, C. | | 登録日 | 2018-10-16 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | R180T variant of delta-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.
Febs J., 286, 2019
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5M3C
 | | Structure of the hybrid domain (GGDEF-EAL) of PA0575 from Pseudomonas aeruginosa PAO1 at 2.8 Ang. with GTP and Ca2+ bound to the active site of the GGDEF domain | | 分子名称: | CALCIUM ION, Diguanylate cyclase, GUANOSINE-5'-TRIPHOSPHATE | | 著者 | Giardina, G, Brunotti, P, Cutruzzola, F, Rinaldo, S. | | 登録日 | 2016-10-14 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.
FEBS J., 285, 2018
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5F9S
 | | Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.7 Angstrom; internal aldimine with PLP in the active site | | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase | | 著者 | Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R. | | 登録日 | 2015-12-10 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
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5HHY
 | | Structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) showing X-Ray induced reduction of PLP internal aldimine to 4'-deoxy-piridoxine-phosphate (PLR) | | 分子名称: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Serine--pyruvate aminotransferase | | 著者 | Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R. | | 登録日 | 2016-01-11 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
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4PVF
 | | Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Serine hydroxymethyltransferase, ... | | 著者 | Giardina, G, Brunotti, P, Fiascarelli, A, Contestabile, R, Cutruzzola, F. | | 登録日 | 2014-03-17 | | 公開日 | 2015-01-28 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Febs J., 282, 2015
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4ZW3
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4ZX4
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4ZX8
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4ZW7
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4ZYQ
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