3RCH

Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the open conformation with LLP and PLP bound to Chain-A and Chain-B respectively

Summary for 3RCH

• Entry DOI: 10.2210/pdb3rch/pdb
• Related: 3RBF 3RBL
• Descriptor: aromatic L-amino acid decarboxylase, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• Functional Keywords: apo enzyme, apo form, open conformation, open dimer, exposed, conformational change, parkinson, aadc deficiency, ddc, llp, plp, decarboxylase, l-dopa, internal aldimine, shiff base, lyase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 108401.65

Authors

Giardina, G.,Montioli, R.,Gianni, S.,Cellini, B.,Paiardini, A.,Borri Voltattorni, C.,Cutruzzola, F. (deposition date: 2011-03-31, release date: 2011-10-19, Last modification date: 2023-12-06)

• Primary citation: Giardina, G.,Montioli, R.,Gianni, S.,Cellini, B.,Paiardini, A.,Voltattorni, C.B.,Cutruzzola, F.; Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.; Proc.Natl.Acad.Sci.USA, 108:20514-20519, 2011; PubMed: 22143761; DOI: 10.1073/pnas.1111456108

Experimental method

X-RAY DIFFRACTION (2.8 Å)