6FL5
Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution
Summary for 6FL5
Entry DOI | 10.2210/pdb6fl5/pdb |
Descriptor | Serine hydroxymethyltransferase, cytosolic, PYRIDOXAL-5'-PHOSPHATE, CHLORIDE ION (3 entities in total) |
Functional Keywords | transferase, serine hydroxymethyltransferase, interface, tetramer, ocm, serine, thf, glicine, tca |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 207913.57 |
Authors | Giardina, G.,Cutruzzola, F.,Lucchi, R. (deposition date: 2018-01-25, release date: 2018-10-10, Last modification date: 2024-01-17) |
Primary citation | Giardina, G.,Paone, A.,Tramonti, A.,Lucchi, R.,Marani, M.,Magnifico, M.C.,Bouzidi, A.,Pontecorvi, V.,Guiducci, G.,Zamparelli, C.,Rinaldo, S.,Paiardini, A.,Contestabile, R.,Cutruzzola, F. The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells. FEBS J., 285:3238-3253, 2018 Cited by PubMed: 30035852DOI: 10.1111/febs.14610 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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