6FL5

Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution

Summary for 6FL5

• Entry DOI: 10.2210/pdb6fl5/pdb
• Descriptor: Serine hydroxymethyltransferase, cytosolic, PYRIDOXAL-5'-PHOSPHATE, CHLORIDE ION (3 entities in total)
• Functional Keywords: transferase, serine hydroxymethyltransferase, interface, tetramer, ocm, serine, thf, glicine, tca
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 207913.57

Authors

Giardina, G.,Cutruzzola, F.,Lucchi, R. (deposition date: 2018-01-25, release date: 2018-10-10, Last modification date: 2024-01-17)

• Primary citation: Giardina, G.,Paone, A.,Tramonti, A.,Lucchi, R.,Marani, M.,Magnifico, M.C.,Bouzidi, A.,Pontecorvi, V.,Guiducci, G.,Zamparelli, C.,Rinaldo, S.,Paiardini, A.,Contestabile, R.,Cutruzzola, F.; The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.; FEBS J., 285:3238-3253, 2018; PubMed: 30035852; DOI: 10.1111/febs.14610

Experimental method

X-RAY DIFFRACTION (3.6 Å)