6FL5
Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, G, J) | Serine hydroxymethyltransferase, cytosolic | polymer | 471 | 51695.8 | 4 | UniProt (P34896) Pfam (PF00464) | Homo sapiens (Human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 2 | E, H, I, K (A, D, G, J) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 4 | Chemie (PLP) | |||
| 3 | F, G, J, L (A, G, J) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) |
Sequence modifications
A, D, G, J: 11 - 481 (UniProt: P34896)
| PDB | External Database | Details |
|---|---|---|
| Asn 135 | His 135 | engineered mutation |
| Ala 137 | Arg 137 | engineered mutation |
| Asn 168 | Glu 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 206783.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1130.4 | |
| All* | Total formula weight | 207913.6 |
