4PVF

Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution

Summary for 4PVF

Entry DOI	10.2210/pdb4pvf/pdb
Descriptor	Serine hydroxymethyltransferase, mitochondrial, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
Functional Keywords	hydroxymethyltransferase, aat-like fold, one carbon metabolism, transferase, 5-formyl-thf, methylase, mitochondrial
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P34897
Total number of polymer chains	2
Total formula weight	107800.19
Authors	Giardina, G.,Brunotti, P.,Fiascarelli, A.,Contestabile, R.,Cutruzzola, F. (deposition date: 2014-03-17, release date: 2015-01-28, Last modification date: 2023-12-06)
Primary citation	Giardina, G.,Brunotti, P.,Fiascarelli, A.,Cicalini, A.,Costa, M.G.,Buckle, A.M.,di Salvo, M.L.,Giorgi, A.,Marani, M.,Paone, A.,Rinaldo, S.,Paiardini, A.,Contestabile, R.,Cutruzzola, F. How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state. Febs J., 282:1225-1241, 2015 Cited by PubMed: 25619277 DOI: 10.1111/febs.13211 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation