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7ES4
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the crystral structure of DndH-C-domain
分子名称: DNA phosphorothioation-dependent restriction protein DptH
著者Wu, D.
登録日2021-05-08
公開日2022-05-11
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex
Nat Catal, 2022
7X6Z
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TRIM7 in complex with C-terminal peptide of NSP12
分子名称: E3 ubiquitin-protein ligase TRIM7, peptide
著者Zhang, H, Liang, X, Li, X.Z.
登録日2022-03-08
公開日2022-08-10
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nat.Chem.Biol., 18, 2022
7X70
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TRIM7 in complex with C-terminal peptide of NSP8
分子名称: E3 ubiquitin-protein ligase TRIM7, peptide
著者Zhang, H, Liang, X, Li, X.Z.
登録日2022-03-08
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nat.Chem.Biol., 18, 2022
7X6Y
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TRIM7 in complex with C-terminal peptide of NSP5
分子名称: E3 ubiquitin-protein ligase TRIM7, peptide
著者Zhang, H, Liang, X, Li, X.Z.
登録日2022-03-08
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nat.Chem.Biol., 18, 2022
7EXX
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The structure of DndG
分子名称: DNA phosphorothioation-dependent restriction protein DptG, SODIUM ION
著者Wu, D, Wang, L.
登録日2021-05-28
公開日2022-06-01
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex
Nat Catal, 2022
7WJQ
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Crystal structure of GSDMB in complex with Ipah7.8
分子名称: Isoform 2 of Gasdermin-B, Probable E3 ubiquitin-protein ligase ipaH7.8
著者Li, X, Zhang, H, Yin, H.
登録日2022-01-07
公開日2023-01-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8
Nat Commun, 14, 2023
7LNI
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BU of 7lni by Molmil
SeMet CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA
分子名称: 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ...
著者Horton, J.R, Cheng, X, Zhou, J.
登録日2021-02-07
公開日2021-05-19
最終更新日2021-07-14
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.
Nat Commun, 12, 2021
7LT5
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BU of 7lt5 by Molmil
CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Cofactor SAH
分子名称: 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ...
著者Horton, J.R, Cheng, X, Zhou, J.
登録日2021-02-18
公開日2021-05-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.
Nat Commun, 12, 2021
7LNJ
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CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA
分子名称: DNA Strand 1, DNA Strand 2, Site-specific DNA-methyltransferase (adenine-specific)
著者Horton, J.R, Cheng, X, Zhou, J.
登録日2021-02-07
公開日2021-05-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.
Nat Commun, 12, 2021
5X4R
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Structure of the N-terminal domain (NTD) of MERS-CoV spike protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S protein
著者Yuan, Y, Zhang, Y, Qi, J, Shi, Y, Gao, G.F.
登録日2017-02-14
公開日2017-05-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
7XPQ
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Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD/UDP-GlcNAc
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
著者Chen, Y.H, Wang, X.C, Zhang, C.R.
登録日2022-05-05
公開日2023-05-17
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis.
Nat Commun, 14, 2023
7XPP
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Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase
著者Chen, Y.H, Wang, X.C, Zhang, C.R.
登録日2022-05-05
公開日2023-05-24
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis.
Nat Commun, 14, 2023
2P8S
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Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor
分子名称: (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Scapin, G, Biftu, T.
登録日2007-03-23
公開日2007-05-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Bioorg.Med.Chem.Lett., 17, 2007
1F6W
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STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN BILE SALT ACTIVATED LIPASE
分子名称: BILE SALT ACTIVATED LIPASE
著者Terzyan, S, Zhang, X.
登録日2000-06-23
公開日2000-10-18
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the catalytic domain of human bile salt activated lipase.
Protein Sci., 9, 2000
4FYO
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Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-pyrrolidin-3-yl}-terephthalamic acid
分子名称: 4-{[(3S)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid, Tyrosine-protein kinase SYK
著者Kuglstatter, A, Slade, M.
登録日2012-07-05
公開日2013-01-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Rational design of highly selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 55, 2012
7VQ1
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BU of 7vq1 by Molmil
Structure of Apo-hsTRPM2 channel
分子名称: Transient receptor potential cation channel subfamily M member 2
著者Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W.
登録日2021-10-18
公開日2021-12-22
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.76 Å)
主引用文献Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel.
Cell Rep, 37, 2021
7VQ2
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Structure of Apo-hsTRPM2 channel TM domain
分子名称: Transient receptor potential cation channel subfamily M member 2
著者Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W.
登録日2021-10-18
公開日2021-12-22
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel.
Cell Rep, 37, 2021
4FZ6
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Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine
分子名称: N-{6-[(2S)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine, Tyrosine-protein kinase SYK
著者Kuglstatter, A, Slade, M.
登録日2012-07-06
公開日2013-01-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Rational design of highly selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 55, 2012
7CBQ
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Crystal structure of PDE4D catalytic domain in complex with Apremilast
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide, ...
著者Zhang, X.L, Xu, Y.C.
登録日2020-06-13
公開日2021-01-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Eur.J.Med.Chem., 211, 2021
7CHA
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Cryo-EM structure of P.aeruginosa MlaFEBD with AMPPNP
分子名称: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, MlaD domain-containing protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Zhou, C, Shi, H, Zhang, M, Huang, Y.
登録日2020-07-05
公開日2021-05-19
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa.
J.Mol.Biol., 433, 2021
2MHM
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Solution structure of cytochrome c Y67H
分子名称: Cytochrome c iso-1, HEME C
著者Lan, W.X, Wang, Z.H, Yang, Z.Z, Ying, T.L, Wu, H.M, Tan, X.S, Cao, C.Y, Huang, Z.X.
登録日2013-11-26
公開日2014-10-29
実験手法SOLUTION NMR
主引用文献Structural Basis for Cytochrome c Y67H Mutant to Function as a Peroxidase
Plos One, 9, 2014
8H69
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Cryo-EM structure of influenza RNA polymerase
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), ...
著者Li, H, Wu, Y, Liang, H, Liu, Y.
登録日2022-10-16
公開日2023-06-28
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles.
Nat.Struct.Mol.Biol., 30, 2023
7CBJ
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Crystal structure of PDE4D catalytic domain in complex with compound 36
分子名称: (1S)-1-[(7-chloranyl-1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
著者Zhang, X.L, Xu, Y.C.
登録日2020-06-12
公開日2021-06-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Eur.J.Med.Chem., 211, 2021
4FYN
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Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-phenylamino}-imidazo[1,2-a]pyrazin-5-yl)-phenol
分子名称: 3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol, Tyrosine-protein kinase SYK
著者Kuglstatter, A, Villasenor, A.G.
登録日2012-07-05
公開日2013-01-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.318 Å)
主引用文献Rational design of highly selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 55, 2012
7CH6
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Cryo-EM structure of E.coli MlaFEB with AMPPNP
分子名称: Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Zhou, C, Shi, H, Zhang, M, Huang, Y.
登録日2020-07-05
公開日2021-08-04
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa.
J.Mol.Biol., 433, 2021

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