4FZ6

Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine

Summary for 4FZ6

Entry DOI	10.2210/pdb4fz6/pdb
Related	4FYN 4FYO
Descriptor	Tyrosine-protein kinase SYK, N-{6-[(2S)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine (3 entities in total)
Functional Keywords	kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34254.45
Authors	Kuglstatter, A.,Slade, M. (deposition date: 2012-07-06, release date: 2013-01-30, Last modification date: 2023-09-13)
Primary citation	Lucas, M.C.,Goldstein, D.M.,Hermann, J.C.,Kuglstatter, A.,Liu, W.,Luk, K.C.,Padilla, F.,Slade, M.,Villasenor, A.G.,Wanner, J.,Xie, W.,Zhang, X.,Liao, C. Rational design of highly selective spleen tyrosine kinase inhibitors. J.Med.Chem., 55:10414-10423, 2012 Cited by PubMed: 23151054 DOI: 10.1021/jm301367c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation