4FYN
Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-phenylamino}-imidazo[1,2-a]pyrazin-5-yl)-phenol
Summary for 4FYN
Entry DOI | 10.2210/pdb4fyn/pdb |
Descriptor | Tyrosine-protein kinase SYK, 3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol (3 entities in total) |
Functional Keywords | kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34273.45 |
Authors | Kuglstatter, A.,Villasenor, A.G. (deposition date: 2012-07-05, release date: 2013-01-30, Last modification date: 2023-09-13) |
Primary citation | Lucas, M.C.,Goldstein, D.M.,Hermann, J.C.,Kuglstatter, A.,Liu, W.,Luk, K.C.,Padilla, F.,Slade, M.,Villasenor, A.G.,Wanner, J.,Xie, W.,Zhang, X.,Liao, C. Rational design of highly selective spleen tyrosine kinase inhibitors. J.Med.Chem., 55:10414-10423, 2012 Cited by PubMed: 23151054DOI: 10.1021/jm301367c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.318 Å) |
Structure validation
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