4FYN

Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-phenylamino}-imidazo[1,2-a]pyrazin-5-yl)-phenol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase SYK	polymer	291	33884.0	1	UniProt (P43405) Pfam (PF07714)	Homo sapiens (human)	Spleen tyrosine kinase, p72-Syk
2	B (A)	3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol	non-polymer		389.4	1	Chemie (0VE)
3	C (A)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	expression tag
Ala 354	-	expression tag
Leu 355	-	expression tag
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33884.0
Non-Polymers*	Number of molecules	1
	Total formula weight	389.4
All*	Total formula weight	34273.5

*Water molecules are not included.