6O2L
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6WB4
| Microbiome-derived Acarbose Kinase Mak1 Labeled with selenomethionine | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Acarbose Kinase Mak1, ... | 著者 | Jeffrey, P.D, Balaich, J.N, Estrella, M.A, Donia, M.S. | 登録日 | 2020-03-26 | 公開日 | 2021-04-21 | 最終更新日 | 2021-12-15 | 実験手法 | X-RAY DIFFRACTION (2.593 Å) | 主引用文献 | The human microbiome encodes resistance to the antidiabetic drug acarbose. Nature, 600, 2021
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6WB5
| Microbiome-derived Acarbose Kinase Mak1 as a Complex with Acarbose and AMP-PNP | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, Acarbose Kinase Mak1, MANGANESE (II) ION, ... | 著者 | Jeffrey, P.D, Balaich, J.N, Estrella, M.A, Donia, M.S. | 登録日 | 2020-03-26 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.102 Å) | 主引用文献 | The human microbiome encodes resistance to the antidiabetic drug acarbose. Nature, 600, 2021
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6WB7
| Acarbose Kinase AcbK as a Complex with Acarbose and AMP-PNP | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, Acarbose 7(IV)-phosphotransferase, MANGANESE (II) ION, ... | 著者 | Jeffrey, P.D, Balaich, J.N, Estrella, M.A, Donia, M.S. | 登録日 | 2020-03-26 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | The human microbiome encodes resistance to the antidiabetic drug acarbose. Nature, 600, 2021
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7ES4
| the crystral structure of DndH-C-domain | 分子名称: | DNA phosphorothioation-dependent restriction protein DptH | 著者 | Wu, D. | 登録日 | 2021-05-08 | 公開日 | 2022-05-11 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex Nat Catal, 2022
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7EXX
| The structure of DndG | 分子名称: | DNA phosphorothioation-dependent restriction protein DptG, SODIUM ION | 著者 | Wu, D, Wang, L. | 登録日 | 2021-05-28 | 公開日 | 2022-06-01 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex Nat Catal, 2022
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7C4A
| nicA2 with cofactor FAD | 分子名称: | Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Xu, P, Zang, K. | 登録日 | 2020-05-15 | 公開日 | 2020-06-03 | 最終更新日 | 2020-12-16 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022). Mbio, 11, 2020
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7C49
| nicA2 with cofactor FAD and substrate nicotine | 分子名称: | 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-2-ol, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Xu, P, Zhang, K. | 登録日 | 2020-05-15 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022). Mbio, 11, 2020
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7WD1
| Crystal structure of R14 bound to SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, R14, Spike protein S1, ... | 著者 | Wang, Q.H, Gao, G.F, Qi, J.X, Su, C, Liu, H.H, Wu, L.L. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice. Cell Rep Med, 4, 2023
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7WD2
| Crystal structure of S43 bound to SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, Q.H, Gao, G.F, Qi, J.X, Su, C, Liu, H.H, Wu, L.L. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice. Cell Rep Med, 4, 2023
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7XUQ
| Crystal structure of Tpe3.0 complexed with N-Boc-3-alkenylindole | 分子名称: | Transcriptional regulator, PadR-like family, dimethyl 2-[[2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]methyl]-2-prop-2-enyl-propanedioate | 著者 | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | 登録日 | 2022-05-19 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Enantioselective [2+2]-cycloadditions with triplet photoenzymes. Nature, 611, 2022
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7XUP
| Crystal structure of TPe3.0 | 分子名称: | Transcriptional regulator, PadR-like family | 著者 | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | 登録日 | 2022-05-19 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Enantioselective [2+2]-cycloadditions with triplet photoenzymes. Nature, 611, 2022
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7F3Q
| SARS-CoV-2 RBD in complex with A5-10 Fab and A34-2 Fab | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of A34-2 Fab, ... | 著者 | Dou, Y, Wang, X, Liu, P, Lu, B, Wang, K. | 登録日 | 2021-06-16 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method. Antib Ther, 6, 2023
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6AGI
| Crystal Structure of EFHA2 in Ca-binding State | 分子名称: | CALCIUM ION, Calcium uptake protein 3, mitochondrial, ... | 著者 | Yangfei, X, Xue, Y, Yuequan, S. | 登録日 | 2018-08-11 | 公開日 | 2019-01-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | 主引用文献 | Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter. Cell Rep, 26, 2019
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6CCW
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3P9U
| Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TetX2 protein | 著者 | Walkiewicz, K, Davlieva, M, Sun, C, Lau, K, Shamoo, Y. | 登録日 | 2010-10-18 | 公開日 | 2011-04-27 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution. Proteins, 79, 2011
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5XV7
| SRPK1 in complex with Alectinib | 分子名称: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, serine-arginine (SR) protein kinase 1 | 著者 | Zeng, C, Ngo, J.C.K. | 登録日 | 2017-06-26 | 公開日 | 2018-03-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform Cell Chem Biol, 25, 2018
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8JVA
| Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N235 and S2L20 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 heavy chain, S2L20 light chain, ... | 著者 | Liu, B, Liu, H.H, Han, P, Qi, J.X. | 登録日 | 2023-06-28 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain. Signal Transduct Target Ther, 9, 2024
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6AGH
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6AGJ
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6ICV
| Structure of SETD3 bound to SAH and unmodified actin | 分子名称: | Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ... | 著者 | Guo, Q, Liao, S, Xu, C, Structural Genomics Consortium (SGC) | 登録日 | 2018-09-07 | 公開日 | 2019-02-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural insights into SETD3-mediated histidine methylation on beta-actin. Elife, 8, 2019
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4JYA
| Crystal structures of pseudouridinilated stop codons with ASLs | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | 登録日 | 2013-03-29 | 公開日 | 2013-06-26 | 最終更新日 | 2013-08-21 | 実験手法 | X-RAY DIFFRACTION (3.098 Å) | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome. Nature, 500, 2013
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4JV5
| Crystal structures of pseudouridinilated stop codons with ASLs | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein 20, 30S ribosomal protein S10, ... | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | 登録日 | 2013-03-25 | 公開日 | 2013-06-26 | 最終更新日 | 2013-08-21 | 実験手法 | X-RAY DIFFRACTION (3.162 Å) | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome. Nature, 500, 2013
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4K0K
| Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | 登録日 | 2013-04-04 | 公開日 | 2013-06-26 | 最終更新日 | 2013-08-21 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome. Nature, 500, 2013
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6JIV
| SspE crystal structure | 分子名称: | SspE protein | 著者 | Bing, Y.Z, Yang, H.G. | 登録日 | 2019-02-23 | 公開日 | 2020-03-25 | 最終更新日 | 2020-07-08 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities. Nat Microbiol, 5, 2020
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