6O2L

NMR structure of the 2:1 complex of a carbazole derivative BMVC bound to c-MYC G-quadruplex

Summary for 6O2L

• Entry DOI: 10.2210/pdb6o2l/pdb
• NMR Information: BMRB: 30577
• Descriptor: DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), 3,6-bis[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-9H-carbazole (2 entities in total)
• Functional Keywords: g-quadruplex dna, drug-dna complex, bmvc, dna
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 7815.55

Authors

Lin, C.,Liu, W.,Yang, D. (deposition date: 2019-02-24, release date: 2019-10-23, Last modification date: 2024-05-01)

• Primary citation: Liu, W.,Lin, C.,Wu, G.,Dai, J.,Chang, T.C.,Yang, D.; Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition.; Nucleic Acids Res., 47:11931-11942, 2019; PubMed: 31740959; DOI: 10.1093/nar/gkz1015

Experimental method

SOLUTION NMR