6WB5

Microbiome-derived Acarbose Kinase Mak1 as a Complex with Acarbose and AMP-PNP

Summary for 6WB5

• Entry DOI: 10.2210/pdb6wb5/pdb
• Related: 6WB4
• Related PRD ID: PRD_900007
• Descriptor: Acarbose Kinase Mak1, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: carbohydrate kinase, acarbose, transferase, nucleotide binding, atp binding, metal ion binding, ribokinase activity, complex
• Biological source: uncultured bacterium
• Total number of polymer chains: 2
• Total formula weight: 70800.48

Authors

Jeffrey, P.D.,Balaich, J.N.,Estrella, M.A.,Donia, M.S. (deposition date: 2020-03-26, release date: 2021-04-21, Last modification date: 2023-10-18)

• Primary citation: Balaich, J.,Estrella, M.,Wu, G.,Jeffrey, P.D.,Biswas, A.,Zhao, L.,Korennykh, A.,Donia, M.S.; The human microbiome encodes resistance to the antidiabetic drug acarbose.; Nature, 600:110-115, 2021; PubMed: 34819672; DOI: 10.1038/s41586-021-04091-0

Experimental method

X-RAY DIFFRACTION (3.102 Å)