4U8A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4u8a by Molmil](/molmil-images/mine/4u8a) | Crystal structure of D(CGCGAATTCGCG)2 complexed with BPH-1503 | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, N,N'-bis[3-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]biphenyl-4,4'-dicarboxamide | 著者 | Zhu, W, Oldfield, E. | 登録日 | 2014-08-01 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Antibacterial drug leads: DNA and enzyme multitargeting. J.Med.Chem., 58, 2015
|
|
7CLI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cli by Molmil](/molmil-images/mine/7cli) | |
4N6Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n6z by Molmil](/molmil-images/mine/4n6z) | Pim1 Complexed with a pyridylcarboxamide | 分子名称: | 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}pyrazine-2-carboxamide, GLYCEROL, Serine/threonine-protein kinase pim-1 | 著者 | Bellamacina, C.R, Le, V, Shu, W, Burger, M.T, Bussiere, D. | 登録日 | 2013-10-14 | 公開日 | 2013-11-06 | 最終更新日 | 2014-07-02 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett, 4, 2013
|
|
6KXS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kxs by Molmil](/molmil-images/mine/6kxs) | Cryo-EM structure of human IgM-Fc in complex with the J chain and the ectodomain of pIgR | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | 著者 | Li, Y, Wang, G, Xiao, J. | 登録日 | 2019-09-12 | 公開日 | 2020-02-05 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural insights into immunoglobulin M. Science, 367, 2020
|
|
6KPP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kpp by Molmil](/molmil-images/mine/6kpp) | BNC105 in complex with tubulin | 分子名称: | (6-methoxy-2-methyl-7-oxidanyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, T, Wu, C, Pu, D. | 登録日 | 2019-08-15 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.74524117 Å) | 主引用文献 | Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design. Biochem.Biophys.Res.Commun., 2020
|
|
4N6Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n6y by Molmil](/molmil-images/mine/4n6y) | Pim1 Complexed with a phenylcarboxamide | 分子名称: | 2-(acetylamino)-N-[2-(piperidin-1-yl)phenyl]-1,3-thiazole-4-carboxamide, Serine/threonine-protein kinase pim-1 | 著者 | Bellamacina, C.R, Le, V, Shu, W, Burger, M.T, Bussiere, D. | 登録日 | 2013-10-14 | 公開日 | 2013-11-06 | 最終更新日 | 2014-07-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett, 4, 2013
|
|
3UX9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ux9 by Molmil](/molmil-images/mine/3ux9) | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus | 分子名称: | Interferon alpha-1/13, ScFv antibody | 著者 | Ouyang, S, Zhao, L.X, Liang, W, Shaw, N, Liu, Z.-J, Liang, M.-F. | 登録日 | 2011-12-04 | 公開日 | 2012-02-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus J.Mol.Med., 2012
|
|
4NIE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nie by Molmil](/molmil-images/mine/4nie) | |
4L8Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4l8z by Molmil](/molmil-images/mine/4l8z) | Crystal structure of Human Hsp90 with RL1 | 分子名称: | Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](3,4-dihydroisoquinolin-2(1H)-yl)methanone | 著者 | Li, J, Ren, J, Yang, M, Xiong, B, He, J. | 登録日 | 2013-06-18 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | 主引用文献 | Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization Bioorg.Med.Chem.Lett., 24, 2014
|
|
2JYF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jyf by Molmil](/molmil-images/mine/2jyf) | |
6AEG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6aeg by Molmil](/molmil-images/mine/6aeg) | Crystal structure of xCas9 in complex with sgRNA and target DNA (GAT PAM) | 分子名称: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*GP*AP*TP*TP*AP*TP*TP*G)-3'), DNA nuclease, ... | 著者 | Guo, M, Ren, K, Zhu, Y, Huang, Z. | 登録日 | 2018-08-04 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Structural insights into a high fidelity variant of SpCas9. Cell Res., 29, 2019
|
|
8ZJB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8zjb by Molmil](/molmil-images/mine/8zjb) | |
7JUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7jup by Molmil](/molmil-images/mine/7jup) | Structure of human TRPA1 in complex with antagonist compound 21 | 分子名称: | 1-({3-[(3R,5R)-5-(4-fluorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L. | 登録日 | 2020-08-20 | 公開日 | 2021-03-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy. J.Med.Chem., 64, 2021
|
|
5EP6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ep6 by Molmil](/molmil-images/mine/5ep6) | The crystal structure of NAP1 in complex with TBK1 | 分子名称: | 5-azacytidine-induced protein 2, GLYCEROL, Serine/threonine-protein kinase TBK1 | 著者 | Li, F, Xie, X, Liu, J, Pan, L. | 登録日 | 2015-11-11 | 公開日 | 2016-09-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | 主引用文献 | Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins. Nat Commun, 7, 2016
|
|
6AEB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6aeb by Molmil](/molmil-images/mine/6aeb) | Crystal structure of xCas9 in complex with sgRNA and target DNA (AAG PAM) | 分子名称: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*AP*AP*GP*TP*AP*TP*TP*G)-3'), DNA Nuclease, ... | 著者 | Guo, M, Ren, K, Zhu, Y, Huang, Z. | 登録日 | 2018-08-04 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.004 Å) | 主引用文献 | Structural insights into a high fidelity variant of SpCas9. Cell Res., 29, 2019
|
|
5EOF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eof by Molmil](/molmil-images/mine/5eof) | Crystal structure of OPTN NTD and TBK1 CTD complex | 分子名称: | Optineurin, Serine/threonine-protein kinase TBK1 | 著者 | Li, F, Xie, X, Liu, J, Pan, L. | 登録日 | 2015-11-10 | 公開日 | 2016-09-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins. Nat Commun, 7, 2016
|
|
7K58
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7k58 by Molmil](/molmil-images/mine/7k58) | |
7KEK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kek by Molmil](/molmil-images/mine/7kek) | |
7K5B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7k5b by Molmil](/molmil-images/mine/7k5b) | |
8GQE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8gqe by Molmil](/molmil-images/mine/8gqe) | Crystal structure of the W285A mutant of UVR8 in complex with RUP2 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ultraviolet-B receptor UVR8, WD repeat-containing protein RUP2 | 著者 | Wang, Y.D, Wang, L.X, Guan, Z.Y, chang, H.F, Yin, P. | 登録日 | 2022-08-30 | 公開日 | 2022-09-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | RUP2 facilitates UVR8 redimerization via two interfaces. Plant Commun., 4, 2023
|
|
1IJR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ijr by Molmil](/molmil-images/mine/1ijr) | Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic | 分子名称: | (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK | 著者 | Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. | 登録日 | 2001-04-27 | 公開日 | 2002-05-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11, 2001
|
|
5TKJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5tkj by Molmil](/molmil-images/mine/5tkj) | Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519 | 分子名称: | HIV-1 fusion peptide residue 512-519, SULFATE ION, vFP1.01 chimeric mouse antibody heavy chain, ... | 著者 | Xu, K, Liu, K, Kwong, P.D. | 登録日 | 2016-10-06 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.118 Å) | 主引用文献 | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018
|
|
7WRO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wro by Molmil](/molmil-images/mine/7wro) | |
7WR8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wr8 by Molmil](/molmil-images/mine/7wr8) | |
7WRL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wrl by Molmil](/molmil-images/mine/7wrl) | |