4N6Z

Pim1 Complexed with a pyridylcarboxamide

Summary for 4N6Z

Entry DOI	10.2210/pdb4n6z/pdb
Related	4N6Y 4N70
Descriptor	Serine/threonine-protein kinase pim-1, 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}pyrazine-2-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	38186.34
Authors	Bellamacina, C.R.,Le, V.,Shu, W.,Burger, M.T.,Bussiere, D. (deposition date: 2013-10-14, release date: 2013-11-06, Last modification date: 2014-07-02)
Primary citation	Burger, M.T.,Han, W.,Lan, J.,Nishiguchi, G.,Bellamacina, C.,Lindval, M.,Atallah, G.,Ding, Y.,Mathur, M.,McBride, C.,Beans, E.L.,Muller, K.,Tamez, V.,Zhang, Y.,Huh, K.,Feucht, P.,Zavorotinskaya, T.,Dai, Y.,Holash, J.,Castillo, J.,Langowski, J.,Wang, Y.,Chen, M.Y.,Garcia, P.D. Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett, 4:1193-1197, 2013 Cited by PubMed: 24900629 DOI: 10.1021/ml400307j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation