4N6Y
Pim1 Complexed with a phenylcarboxamide
Summary for 4N6Y
| Entry DOI | 10.2210/pdb4n6y/pdb |
| Related | 4N6Z 4N70 |
| Descriptor | Serine/threonine-protein kinase pim-1, 2-(acetylamino)-N-[2-(piperidin-1-yl)phenyl]-1,3-thiazole-4-carboxamide (3 entities in total) |
| Functional Keywords | kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
| Total number of polymer chains | 1 |
| Total formula weight | 37941.13 |
| Authors | Bellamacina, C.R.,Le, V.,Shu, W.,Burger, M.T.,Bussiere, D. (deposition date: 2013-10-14, release date: 2013-11-06, Last modification date: 2014-07-02) |
| Primary citation | Burger, M.T.,Han, W.,Lan, J.,Nishiguchi, G.,Bellamacina, C.,Lindval, M.,Atallah, G.,Ding, Y.,Mathur, M.,McBride, C.,Beans, E.L.,Muller, K.,Tamez, V.,Zhang, Y.,Huh, K.,Feucht, P.,Zavorotinskaya, T.,Dai, Y.,Holash, J.,Castillo, J.,Langowski, J.,Wang, Y.,Chen, M.Y.,Garcia, P.D. Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett, 4:1193-1197, 2013 Cited by PubMed: 24900629DOI: 10.1021/ml400307j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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