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Structural basis for the binding between Tankyrase-1 and USP25
分子名称:	GLYCEROL, Tankyrase-1, Ubiquitin carboxyl-terminal hydrolase 25
著者	Liu, J, Xu, D, Fu, T, Pan, L.
登録日	2016-08-01
公開日	2017-07-12
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.502 Å)
主引用文献	USP25 regulates Wnt signaling by controlling the stability of tankyrases Genes Dev., 31, 2017

2NRN

Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant
分子名称:	General control protein GCN4, PHOSPHATE ION
著者	Liu, J, Lu, M.
登録日	2006-11-02
公開日	2007-04-17
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant. Protein Sci., 16, 2007

3CK4

A heterospecific leucine zipper tetramer
分子名称:	GCN4 leucine zipper, MAGNESIUM ION
著者	Liu, J.
登録日	2008-03-14
公開日	2008-10-07
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	A heterospecific leucine zipper tetramer. Chem.Biol., 15, 2008

3CRP

A heterospecific leucine zipper tetramer
分子名称:	GCN4 leucine zipper, SODIUM ION
著者	Liu, J.
登録日	2008-04-07
公開日	2008-10-07
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	A heterospecific leucine zipper tetramer. Chem.Biol., 15, 2008

3DNL

Molecular structure for the HIV-1 gp120 trimer in the b12-bound state
分子名称:	HIV-1 envelope glycoprotein gp120
著者	Borgnia, M.J, Liu, J, Bartesaghi, A, Sapiro, G, Subramaniam, S.
登録日	2008-07-02
公開日	2008-08-19
最終更新日	2018-07-18
実験手法	ELECTRON MICROSCOPY (20 Å)
主引用文献	Molecular architecture of native HIV-1 gp120 trimers. Nature, 455, 2008

4IDT

Crystal Structure of NIK with 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine (T28)
分子名称:	11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine, Mitogen-activated protein kinase kinase kinase 14
著者	Liu, J, Sudom, A, Wang, Z.
登録日	2012-12-13
公開日	2013-04-17
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures Bioorg.Med.Chem.Lett., 23, 2013

3DNO

Molecular structure for the HIV-1 gp120 trimer in the CD4-bound state
分子名称:	HIV-1 envelope glycoprotein gp120
著者	Borgnia, M.J, Liu, J, Bartesaghi, A, Sapiro, G, Subramaniam, S.
登録日	2008-07-02
公開日	2008-08-19
最終更新日	2018-07-18
実験手法	ELECTRON MICROSCOPY (20 Å)
主引用文献	Molecular architecture of native HIV-1 gp120 trimers. Nature, 455, 2008

3DNN

Molecular structure for the HIV-1 gp120 trimer in the unliganded state
分子名称:	HIV-1 envelope glycoprotein gp120
著者	Borgnia, M.J, Liu, J, Bartesaghi, A, Sapiro, G, Subramaniam, S.
登録日	2008-07-02
公開日	2008-08-19
最終更新日	2018-07-18
実験手法	ELECTRON MICROSCOPY (20 Å)
主引用文献	Molecular architecture of native HIV-1 gp120 trimers. Nature, 455, 2008

4IDV

Crystal Structure of NIK with compound 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol (13V)
分子名称:	4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol, Mitogen-activated protein kinase kinase kinase 14
著者	Liu, J, Sudom, A, Wang, Z.
登録日	2012-12-13
公開日	2013-04-17
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures Bioorg.Med.Chem.Lett., 23, 2013

2LSJ

Solution structure of the mouse Rev1 CTD in complex with the Rev1-interacting Region (RIR)of Pol Kappa
分子名称:	DNA polymerase kappa, DNA repair protein REV1
著者	Liu, J, Wojtaszek, J, Zhou, P.
登録日	2012-05-01
公開日	2012-06-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa. J.Biol.Chem., 287, 2012

2LSG

Solution structure of the mouse Rev1 C-terminal domain
分子名称:	DNA repair protein REV1
著者	Liu, J, Wojtaszek, J, Zhou, P.
登録日	2012-04-30
公開日	2012-06-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa. J.Biol.Chem., 287, 2012

4B7Q

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE, ...
著者	Liu, J, van der Vries, E, Vachieri, S.G, Xiong, X, Collins, P.J, Walker, P.A, Haire, L.F, Hay, A.J, Schutten, M, Osterhaus, A.D.M.E, Martin, S.R, Boucher, C.A.B, Skehel, J.J, Gamblin, S.J.
登録日	2012-08-21
公開日	2012-10-03
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.728 Å)
主引用文献	H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis Plos Pathog., 8, 2012

4B7R

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis
分子名称:	(3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Liu, J, van der Vries, E, Vachieri, S.G, Xiong, X, Collins, P.J, Walker, P.A, Haire, L.F, Hay, A.J, Schutten, M, Osterhaus, A.D.M.E, Martin, S.R, Boucher, C.A.B, Skehel, J.J, Gamblin, S.J.
登録日	2012-08-21
公開日	2012-10-03
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis Plos Pathog., 8, 2012

4CQZ

Crystal Structure of H5 (VN1194) Gln196Arg Mutant Haemagglutinin
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Liu, J, Xiong, X, Xiao, H, Martin, S.R, Coombs, P.J, Collins, P.J, Vachieri, S.G, Walker, P.A, Lin, Y.P, McCauley, J.W, Gamblin, S.J, Skehel, J.J.
登録日	2014-02-21
公開日	2014-05-28
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Enhanced Human Receptor Binding by H5 Haemagglutinins. Virology, 456, 2014

7D6H

Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant
分子名称:	PHOSPHATE ION, Papain-like protease, ZINC ION
著者	Liu, J, Wang, Y, Pan, L.
登録日	2020-09-30
公開日	2020-11-04
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol, 28, 2021

7E35

Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant bound to compound S43
分子名称:	N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Non-structural protein 3, ZINC ION
著者	Liu, J, Wang, Y, Xu, X, Pan, L.
登録日	2021-02-08
公開日	2021-03-17
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol, 28, 2021

4DN5

Crystal Structure of NF-kB-inducing Kinase (NIK)
分子名称:	1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ...
著者	Min, X, Liu, J, Sudom, A, Walker, N.P, Wang, Z.
登録日	2012-02-08
公開日	2012-06-27
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Structure of Nuclear Factor Kappa B-inducing kinase domain reveals a constitutively active conformation J.Biol.Chem., 287, 2012

7LKY

Crystal Structure of PHF1 Tudor domain in complex with a peptidomimetic ligand UNC6641
分子名称:	DIMETHYL SULFOXIDE, Isoform 1 of PHD finger protein 1, Peptidomimetic inhibitor UNC6641, ...
著者	Liu, J, Kutateladze, T.G.
登録日	2021-02-03
公開日	2021-12-15
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). J.Med.Chem., 64, 2021

4F0I

Crystal structure of apo TrkA
分子名称:	High affinity nerve growth factor receptor
著者	Liu, J.
登録日	2012-05-04
公開日	2012-09-05
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.302 Å)
主引用文献	The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition. J.Mol.Biol., 423, 2012

6CI0

Catalytic core subunits (I and II) of cytochrome C oxidase from Rhodobacter sphaeroides with E101A (II) mutation
分子名称:	(2S,3R)-heptane-1,2,3-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, ...
著者	Liu, J, Hiser, C, Ferguson-Miller, S.
登録日	2018-02-23
公開日	2018-04-25
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	The K-path entrance in cytochrome c oxidase is defined by mutation of E101 and controlled by an adjacent ligand binding domain. Biochim. Biophys. Acta, 1859, 2018

3VBX

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称:	6-bromo-4-hydroxy-2H-chromen-2-one, Serine/threonine-protein kinase pim-1
著者	Liu, J.
登録日	2012-01-02
公開日	2012-03-21
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.03 Å)
主引用文献	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3VC4

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称:	(5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, IMIDAZOLE, Serine/threonine-protein kinase pim-1
著者	Liu, J.
登録日	2012-01-03
公開日	2012-03-21
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.23 Å)
主引用文献	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3VBT

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称:	4-chloro-2-(1H-pyrazol-3-yl)phenol, Serine/threonine-protein kinase pim-1
著者	Liu, J.
登録日	2012-01-02
公開日	2012-03-21
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.23 Å)
主引用文献	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3VBV

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称:	8-hydroxyquinoline-2-carboxamide, Serine/threonine-protein kinase pim-1
著者	Liu, J.
登録日	2012-01-02
公開日	2012-03-21
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.08 Å)
主引用文献	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3VBQ

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称:	(5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione, Serine/threonine-protein kinase pim-1
著者	Liu, J.
登録日	2012-01-02
公開日	2012-03-21
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

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