5IT3
| Swirm domain of human Lsd1 | 分子名称: | Lysine-specific histone demethylase 1A, MAGNESIUM ION | 著者 | Jeffrey, P.D, Yuan, P. | 登録日 | 2016-03-16 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A Tlx-interacting peptide of Lsd1 inhibits the proliferation of brain tumor stem cells To Be Published
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7VP9
| Crystal structure of human ClpP in complex with ZG111 | 分子名称: | (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | 著者 | Wang, P.Y, Gan, J.H, Yang, C.-G. | 登録日 | 2021-10-15 | 公開日 | 2022-06-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | 主引用文献 | Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma. Cell Chem Biol, 29, 2022
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5YP6
| RORgamma (263-509) complexed with SRC2 and Compound 6 | 分子名称: | N-[3'-cyano-4'-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, SRC2 | 著者 | Gao, M, Cai, W. | 登録日 | 2017-11-01 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists ACS Med Chem Lett, 9, 2018
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7LH7
| Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor | 分子名称: | Bcl-2-like protein 1, N-(1,3-benzothiazol-2-yl)-2-(4-{[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]carbamoyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide | 著者 | Judge, R.A, Tao, Z. | 登録日 | 2021-01-21 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.409 Å) | 主引用文献 | Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor ACS Medicinal Chemistry Letters, 12, 2021
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8TDZ
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8TE0
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8TDY
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8TE2
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8TMA
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8TM1
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7N1R
| A novel and unique ATP hydrolysis to AMP by a human Hsp70 BiP | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP, ... | 著者 | Yang, J, Musayev, F, Liu, Q. | 登録日 | 2021-05-28 | 公開日 | 2022-01-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP). Protein Sci., 31, 2022
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7NAM
| LRP6_E1 in complex with Lr-EET-3.5 | 分子名称: | Low-density lipoprotein receptor-related protein 6, SODIUM ION, Trypsin inhibitor 2, ... | 著者 | Hansen, S, Hannoush, R.N. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/ beta-catenin signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
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5WY2
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5X80
| CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH SALICYLIC ACID | 分子名称: | 2-HYDROXYBENZOIC ACID, SULFATE ION, Uncharacterized HTH-type transcriptional regulator Rv2887 | 著者 | Gao, Y.R, Li, D.F, Wang, D.C, Bi, L.J. | 登録日 | 2017-02-28 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis Sci Rep, 7, 2017
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7UJD
| PSMD2 Structure bound to MC1 and Fab8/14 | 分子名称: | 26S proteasome non-ATPase regulatory subunit 2, ACY-PHE-PRO-ASP-VAL-SAR-LEU-HIS-ARG-TYR-TRP-GLY-TRP-ASP-CYS-GLY-NH2, Fab 14 HC CDRs, ... | 著者 | Johnson, M.C, Bashore, C, Ciferri, C, Dueber, E.C. | 登録日 | 2022-03-30 | 公開日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Targeted degradation via direct 26S proteasome recruitment. Nat.Chem.Biol., 19, 2023
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7UIH
| PSMD2 Structure | 分子名称: | 26S proteasome non-ATPase regulatory subunit 2, Fab 14 HC CDRs, Fab 14 LC CDRs, ... | 著者 | Johnson, M.C, Bashore, C, Ciferri, C, Dueber, E.C. | 登録日 | 2022-03-29 | 公開日 | 2023-01-11 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Targeted degradation via direct 26S proteasome recruitment. Nat.Chem.Biol., 19, 2023
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5X7Z
| CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH P-AMINOSALICYLIC ACID | 分子名称: | 2-HYDROXY-4-AMINOBENZOIC ACID, Uncharacterized HTH-type transcriptional regulator Rv2887 | 著者 | Gao, Y.R, Li, D.F, Wang, D.C, Bi, L.J. | 登録日 | 2017-02-28 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis Sci Rep, 7, 2017
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7VLN
| NSD2-PWWP1 domain bound with an imidazol-5-yl benzonitrile compound | 分子名称: | 4-[5-[4-(aminomethyl)-2,6-dimethoxy-phenyl]-3-methyl-imidazol-4-yl]benzenecarbonitrile, Histone-lysine N-methyltransferase NSD2 | 著者 | Cao, D.Y, Li, Y.L, Li, J, Xiong, B. | 登録日 | 2021-10-05 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J.Med.Chem., 65, 2022
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3WSQ
| Structure of HER2 with an Fab | 分子名称: | Antibody Heavy Chain, Antibody Light Chain, Receptor tyrosine-protein kinase erbB-2 | 著者 | Fu, W.Y, Wang, Y.X, Zhou, L.J. | 登録日 | 2014-03-20 | 公開日 | 2015-03-25 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies. MAbs, 6, 2014
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5YF4
| A kinase complex MST4-MOB4 | 分子名称: | MOB-like protein phocein, Peptide from Serine/threonine-protein kinase 26, ZINC ION | 著者 | Chen, M, Zhou, Z.C. | 登録日 | 2017-09-20 | 公開日 | 2018-08-15 | 最終更新日 | 2018-09-26 | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | 主引用文献 | The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. J. Biol. Chem., 293, 2018
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6SEQ
| Lemur tyrosine kinase 3 (LMTK3) | 分子名称: | Serine/threonine-protein kinase LMTK3 | 著者 | Roe, S.M, Owen, R. | 登録日 | 2019-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structure-function relationship of oncogenic LMTK3. Sci Adv, 6, 2020
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7FAH
| Immune complex of head region of CA09 HA and neutralizing antibody 12H5 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | 著者 | Li, T.T, Xue, W.H, Gu, Y, Li, S.W. | 登録日 | 2021-07-06 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.151 Å) | 主引用文献 | Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun, 13, 2022
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6U6J
| RNA-monomer complex containing pyrophosphate linkage | 分子名称: | 5'-O-[(R)-(2-amino-1H-imidazol-1-yl)(hydroxy)phosphoryl]guanosine, RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(DPG))-3') | 著者 | Zhang, W, Szostak, J.W, Giurgiu, C, Wright, T. | 登録日 | 2019-08-29 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Prebiotically Plausible "Patching" of RNA Backbone Cleavage through a 3'-5' Pyrophosphate Linkage. J.Am.Chem.Soc., 141, 2019
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3QAU
| 3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae | 分子名称: | 3-hydroxy-3-methylglutaryl-coenzyme a reductase, GLYCEROL, SODIUM ION, ... | 著者 | Zhang, L, Feng, L, Zhou, L, Gui, J, Wan, J. | 登録日 | 2011-01-11 | 公開日 | 2011-01-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae To be Published
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3QAE
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae | 分子名称: | 3-hydroxy-3-methylglutaryl-coenzyme a reductase, CITRIC ACID, GLYCEROL, ... | 著者 | Zhang, L, Feng, L, Zhou, L, Gui, J, Wan, J. | 登録日 | 2011-01-10 | 公開日 | 2011-01-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae To be Published
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