7VLN

NSD2-PWWP1 domain bound with an imidazol-5-yl benzonitrile compound

Summary for 7VLN

Entry DOI	10.2210/pdb7vln/pdb
Descriptor	Histone-lysine N-methyltransferase NSD2, 4-[5-[4-(aminomethyl)-2,6-dimethoxy-phenyl]-3-methyl-imidazol-4-yl]benzenecarbonitrile (2 entities in total)
Functional Keywords	histone-lysine n-methyltransferase nsd2, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	45772.91
Authors	Cao, D.Y.,Li, Y.L.,Li, J.,Xiong, B. (deposition date: 2021-10-05, release date: 2022-07-06, Last modification date: 2023-11-29)
Primary citation	Li, N.,Yang, H.,Liu, K.,Zhou, L.,Huang, Y.,Cao, D.,Li, Y.,Sun, Y.,Yu, A.,Du, Z.,Yu, F.,Zhang, Y.,Wang, B.,Geng, M.,Li, J.,Xiong, B.,Xu, S.,Huang, X.,Liu, T. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J.Med.Chem., 65:9459-9477, 2022 Cited by PubMed: 35704853 DOI: 10.1021/acs.jmedchem.2c00709 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.09 Å)

Structure validation