Structure of HER2 with an Fab

Summary for 3WSQ

DescriptorReceptor tyrosine-protein kinase erbB-2, Antibody Light Chain, Antibody Heavy Chain (3 entities in total)
Functional Keywordskinase, transferase-immune system complex, transferase/immune system
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm P04626
Total number of polymer chains3
Total molecular weight107840
Fu, W.Y.,Wang, Y.X.,Zhou, L.J. (deposition date: 2014-03-20, release date: 2015-03-25, Last modification date: 2017-11-22)
Primary citation
Fu, W.,Wang, Y.,Zhang, Y.,Xiong, L.,Takeda, H.,Ding, L.,Xu, Q.,He, L.,Tan, W.,Bethune, A.N.,Zhou, L.
Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies.
MAbs, 6:978-990, 2014
PubMed: 24838231 (PDB entries with the same primary citation)
DOI: 10.4161/mabs.28786
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.340236.9%16.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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