7LZ7
| Tubulin-RB3_SLD-TTL in complex with compound 5k | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(3,6-dimethyl[1,2]oxazolo[5,4-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2021-03-09 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
|
|
7NQK
| Cryo-EM structure of the mammalian peptide transporter PepT2 | 分子名称: | Solute carrier family 15 member 2, nanobody | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | 登録日 | 2021-03-01 | 公開日 | 2021-07-07 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals. Sci Adv, 7, 2021
|
|
5I4V
| Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists | 分子名称: | Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-02-12 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
|
|
3VG0
| Antibody Fab fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Monoclonal antibody 9F8 Fab fragment H chain, ... | 著者 | Carpenter, B, Hemsworth, G.R, Ross, R.J, Artymiuk, P.J. | 登録日 | 2012-01-10 | 公開日 | 2012-03-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure, 20, 2012
|
|
1ZMH
| Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala) | 分子名称: | GLYCEROL, HEXAETHYLENE GLYCOL, Neutrophil defensin 2, ... | 著者 | Lubkowski, J, Prahl, A, Lu, W. | 登録日 | 2005-05-10 | 公開日 | 2005-08-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids. J.Biol.Chem., 280, 2005
|
|
1ZMK
| Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group | 分子名称: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 2 | 著者 | Lubkowski, J, Prahl, A, Lu, W. | 登録日 | 2005-05-10 | 公開日 | 2005-08-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids. J.Biol.Chem., 280, 2005
|
|
1ZMP
| Crystal structure of human defensin-5 | 分子名称: | CHLORIDE ION, Defensin 5, GLYCEROL, ... | 著者 | Lubkowski, J, Szyk, A, Lu, W. | 登録日 | 2005-05-10 | 公開日 | 2006-05-30 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structures of human {alpha}-defensins HNP4, HD5, and HD6. Protein Sci., 15, 2006
|
|
3ZNR
| HDAC7 bound with inhibitor TMP269 | 分子名称: | HISTONE DEACETYLASE 7, N-{[4-(4-phenyl-1,3-thiazol-2-yl)tetrahydro-2H-pyran-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide, POTASSIUM ION, ... | 著者 | Lobera, m, madauss, k, pohlhaus, d, trump, r, nolan, m. | 登録日 | 2013-02-15 | 公開日 | 2013-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group Nat.Chem.Biol., 9, 2013
|
|
1ZMQ
| Crystal structure of human alpha-defensin-6 | 分子名称: | CHLORIDE ION, Defensin 6 | 著者 | Lubkowski, J, Szyk, A, Lu, W. | 登録日 | 2005-05-10 | 公開日 | 2006-05-30 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of human {alpha}-defensins HNP4, HD5, and HD6. Protein Sci., 15, 2006
|
|
3ZNS
| HDAC7 bound with TFMO inhibitor tmp942 | 分子名称: | HISTONE DEACETYLASE 7, N-{[1-methyl-4-(4-phenyl-1,3-thiazol-2-yl)piperidin-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide, POTASSIUM ION, ... | 著者 | Lobera, M, Madauss, K.P, Pohlhaus, D.T, Trump, R.P, Nolan, M.A. | 登録日 | 2013-02-15 | 公開日 | 2013-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group Nat.Chem.Biol., 9, 2013
|
|
3V6O
| Leptin Receptor-antibody complex | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Carpenter, B, Hemsworth, G.R, Ross, R.J, Artymiuk, P.J. | 登録日 | 2011-12-20 | 公開日 | 2012-03-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure, 20, 2012
|
|
1ZMI
| Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group ) | 分子名称: | GLYCEROL, Neutrophil defensin 2, SULFATE ION | 著者 | Lubkowski, J, Prahl, A, Lu, W. | 登録日 | 2005-05-10 | 公開日 | 2005-08-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids. J.Biol.Chem., 280, 2005
|
|
1ZMM
| |
8GJK
| Multi-drug efflux pump RE-CmeB bound with ampicillin | 分子名称: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter | 著者 | Zhang, Z. | 登録日 | 2023-03-16 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
|
|
8GK4
| Multi-drug efflux pump RE-CmeB bound with Chloramphenicol | 分子名称: | CHLORAMPHENICOL, Efflux pump membrane transporter | 著者 | Zhang, Z. | 登録日 | 2023-03-17 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
|
|
8GK0
| Multi-drug efflux pump RE-CmeB bound with Erythromycin | 分子名称: | ERYTHROMYCIN A, Efflux pump membrane transporter | 著者 | Zhang, Z. | 登録日 | 2023-03-16 | 公開日 | 2023-06-07 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
|
|
8GJL
| multi-drug efflux pump RE-CmeB bound with Ciprofloxacin | 分子名称: | 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Efflux pump membrane transporter | 著者 | Zhang, Z. | 登録日 | 2023-03-16 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
|
|
8GJJ
| Multi-drug efflux pump RE-CmeB Apo form | 分子名称: | Efflux pump membrane transporter | 著者 | Zhang, Z. | 登録日 | 2023-03-15 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
|
|
8GK7
| MsbA bound to cerastecin C | 分子名称: | 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid, Lipid A export ATP-binding/permease protein MsbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Chen, Y, Klein, D. | 登録日 | 2023-03-17 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii. Nat Microbiol, 9, 2024
|
|
8DIQ
| Tubulin-RB3_SLD-TTL in complex with SB226 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[2-(ethylamino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2022-06-29 | 公開日 | 2023-01-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.395 Å) | 主引用文献 | SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis. Cancer Lett., 555, 2022
|
|
8HMV
| Structure of GPR21-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Wong, T.S, Gao, W. | 登録日 | 2022-12-05 | 公開日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Cryo-EM structure of orphan G protein-coupled receptor GPR21. MedComm (2020), 4, 2023
|
|
8IAZ
| Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex | 分子名称: | DNA (5'-D(P*AP*CP*AP*TP*GP*GP*AP*CP*CP*AP*TP*CP*AP*GP*CP*TP*CP*CP*TP*AP*AP*TP*GP*G)-3'), DNA (5'-D(P*CP*CP*AP*TP*TP*AP*GP*GP*AP*GP*CP*TP*GP*AP*TP*G)-3'), RNA (207-MER), ... | 著者 | Yin, M, Zhou, F, Zhu, Y, Huang, Z. | 登録日 | 2023-02-09 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs. Cell Res., 34, 2024
|
|
8X5X
| |
3GXA
| Crystal structure of GNA1946 | 分子名称: | METHIONINE, Outer membrane lipoprotein GNA1946, SULFATE ION | 著者 | Yang, X, Shen, Y. | 登録日 | 2009-04-02 | 公開日 | 2009-10-13 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structure of lipoprotein GNA1946 from Neisseria meningitidis J.Struct.Biol., 168, 2009
|
|
3HJ2
| |