8DIQ

Tubulin-RB3_SLD-TTL in complex with SB226

Summary for 8DIQ

• Entry DOI: 10.2210/pdb8diq/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[2-(ethylamino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, ... (14 entities in total)
• Functional Keywords: microtubule inhibitor, colchicine, cell cycle, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265342.23

Authors

White, S.W.,Yun, M. (deposition date: 2022-06-29, release date: 2023-01-18, Last modification date: 2023-10-25)

• Primary citation: Deng, S.,Banerjee, S.,Chen, H.,Pochampally, S.,Wang, Y.,Yun, M.K.,White, S.W.,Parmar, K.,Meibohm, B.,Hartman, K.L.,Wu, Z.,Miller, D.D.,Li, W.; SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis.; Cancer Lett., 555:216046-216046, 2022; PubMed: 36596380; DOI: 10.1016/j.canlet.2022.216046

Experimental method

X-RAY DIFFRACTION (2.395 Å)