5CET
| Crystal structure of Rv2837c | 分子名称: | Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION | 著者 | Wang, F, He, Q, Zhu, D, Liu, S, Gu, L. | 登録日 | 2015-07-07 | 公開日 | 2015-12-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase J.Biol.Chem., 291, 2016
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5C15
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5FOB
| Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COMPLEMENT C3 BETA CHAIN, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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1SZJ
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6AZU
| Holo IDO1 crystal structure | 分子名称: | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | Lewis, H.A, Yan, C. | 登録日 | 2017-09-13 | 公開日 | 2018-03-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.822 Å) | 主引用文献 | Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2M5E
| Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2 | 分子名称: | CALCIUM ION, Calmodulin, Sodium channel protein type 2 subunit alpha | 著者 | Fowler, C.A, Feldkamp, M.D, Yu, L, Shea, M.A. | 登録日 | 2013-02-21 | 公開日 | 2014-07-23 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2. Biophys. Chem., 224, 2017
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5YJH
| Structural insights into periostin functions | 分子名称: | CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Liu, H, Liu, J, Xu, F. | 登録日 | 2017-10-10 | 公開日 | 2018-05-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.957 Å) | 主引用文献 | Structural characterizations of human periostin dimerization and cysteinylation. FEBS Lett., 592, 2018
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6AZW
| IDO1/FXB-001116 crystal structure | 分子名称: | (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide, Indoleamine 2,3-dioxygenase 1 | 著者 | Lewis, H.A, Lammens, A, Steinbacher, S. | 登録日 | 2017-09-13 | 公開日 | 2018-03-21 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5YJG
| Structural insights into periostin functions | 分子名称: | CALCIUM ION, CHLORIDE ION, CYSTEINE, ... | 著者 | Liu, H, Liu, J, Xu, F. | 登録日 | 2017-10-10 | 公開日 | 2018-05-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.399 Å) | 主引用文献 | Structural characterizations of human periostin dimerization and cysteinylation. FEBS Lett., 592, 2018
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6AZV
| IDO1/BMS-978587 crystal structure | 分子名称: | (1R,2S)-2-(4-[bis(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, Indoleamine 2,3-dioxygenase 1 | 著者 | Lewis, H.A. | 登録日 | 2017-09-13 | 公開日 | 2018-03-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | 主引用文献 | Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2MXP
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2P63
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2Q1L
| Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors | 分子名称: | (3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID, 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 著者 | Pavlovsky, A, Pfefferkorn, J.A, Harris, M.S, Finzel, B.C. | 登録日 | 2007-05-24 | 公開日 | 2007-07-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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2P64
| D domain of b-TrCP | 分子名称: | CADMIUM ION, F-box/WD repeat protein 1A | 著者 | Neculai, D, Orlicky, S, Ceccarelli, D. | 登録日 | 2007-03-16 | 公開日 | 2007-06-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell(Cambridge,Mass.), 129, 2007
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2Q6C
| Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors | 分子名称: | (3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION | 著者 | Pavlovsky, A, Pfefferkorn, J.A, Harris, M.S, Finzel, B.C. | 登録日 | 2007-06-04 | 公開日 | 2007-07-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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2Q6B
| Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors | 分子名称: | (3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION | 著者 | Pavlovsky, A, Pfefferkorn, J.A, Harris, M.S, Finzel, B.C. | 登録日 | 2007-06-04 | 公開日 | 2007-07-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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2NPP
| Structure of the Protein Phosphatase 2A Holoenzyme | 分子名称: | MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ... | 著者 | Xu, Y, Chen, Y, Xing, Y, Chao, Y, Shi, Y. | 登録日 | 2006-10-28 | 公開日 | 2006-12-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of the protein phosphatase 2A holoenzyme Cell(Cambridge,Mass.), 127, 2006
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2R4F
| Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors | 分子名称: | (3R,5R)-7-[1-(4-fluorophenyl)-4-(1-methylethyl)-3-{methyl[(1R)-1-phenylethyl]carbamoyl}-1H-pyrazol-5-yl]-3,5-dihydroxyheptanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION | 著者 | Pavlovsky, A, Pfefferkorn, J.A, Harris, M.S, Finzel, B.C. | 登録日 | 2007-08-31 | 公開日 | 2008-04-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J.Med.Chem., 51, 2008
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5FOA
| Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4) | 分子名称: | COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (4.188 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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3QWQ
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3QWR
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3RT0
| Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA) | 分子名称: | Abscisic acid receptor PYL10, MAGNESIUM ION, Protein phosphatase 2C 16 | 著者 | Hao, Q, Yin, P, Li, W, Wang, L, Yan, C, Wang, J, Yan, N. | 登録日 | 2011-05-02 | 公開日 | 2011-06-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.113 Å) | 主引用文献 | The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins Mol.Cell, 42, 2011
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3T46
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3T49
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3T47
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