7UM6
| CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride | 分子名称: | 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM7
| CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine | 分子名称: | (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UU5
| Crystal structure of APOBEC3G complex with 5'-Overhang dsRNA | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*AP*AP*CP*CP*GP*CP*AP*GP*CP*G)-3'), RNA (5'-R(P*UP*AP*AP*CP*GP*CP*UP*GP*CP*GP*G)-3'), ... | 著者 | Yang, H, Li, S, Chen, X.S. | 登録日 | 2022-04-28 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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7UU4
| Crystal structure of APOBEC3G complex with ssRNA | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*AP*AP*UP*UP*U)-3'), SULFATE ION, ... | 著者 | Yang, H, Li, S, Chen, X.S. | 登録日 | 2022-04-28 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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7UU3
| Crystal structure of APOBEC3G complex with 3'overhangs RNA-Complex | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(*CP*CP*CP*AP*CP*GP*GP*GP*AP*AP*U)-3'), RNA (5'-R(*CP*CP*CP*GP*UP*GP*GP*GP*AP*AP*U)-3'), ... | 著者 | Yang, H, Li, S, Chen, X.S. | 登録日 | 2022-04-28 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.099 Å) | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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4CQG
| The crystal structure of MPK38 in complex with OTSSP167, an orally- administrative MELK selective inhibitor | 分子名称: | 1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-({trans-4-[(dimethylamino)methyl]cyclohexyl}amino)-1,5-naphthyridin-3-yl]ethanone, Maternal embryonic leucine zipper kinase, SULFATE ION | 著者 | Cho, Y.S, Kang, Y.J, Cho, H.S. | 登録日 | 2014-02-17 | 公開日 | 2014-07-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem.Biophys.Res.Commun., 447, 2014
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8FVJ
| Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5 | 分子名称: | Core-binding factor subunit beta, Cullin-5, Elongin-B, ... | 著者 | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | 登録日 | 2023-01-19 | 公開日 | 2023-09-06 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
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8FVI
| Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 | 分子名称: | Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... | 著者 | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | 登録日 | 2023-01-19 | 公開日 | 2023-09-06 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
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3F82
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6VI4
| Nanobody-Enabled Monitoring of Kappa Opioid Receptor States | 分子名称: | (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CHOLESTEROL, Kappa opioid receptor, ... | 著者 | Che, T, Roth, B.L. | 登録日 | 2020-01-11 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Nanobody-enabled monitoring of kappa opioid receptor states. Nat Commun, 11, 2020
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8K55
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8K57
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3VQR
| Structure of a dye-linked L-proline dehydrogenase mutant from the aerobic hyperthermophilic archaeon, Aeropyrum pernix | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Sakuraba, H, Ohshima, T, Satomura, T, Yoneda, K. | 登録日 | 2012-03-29 | 公開日 | 2012-04-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Crystal Structure of Novel Dye-linked L-Proline Dehydrogenase from Hyperthermophilic Archaeon Aeropyrum pernix J.Biol.Chem., 287, 2012
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8EDJ
| Crystal structure of rA3G-ssRNA-GA | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*GP*AP*UP*UP*U)-3'), SULFATE ION, ... | 著者 | Pacheco, J, Yang, H.J, Li, S.-X, Chen, X.S. | 登録日 | 2022-09-04 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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8DVX
| Structure of acetylated Pig somatic Cytochrome c (Aly39) at 1.5A | 分子名称: | Cytochrome c, HEME C, HEXACYANOFERRATE(3-) | 著者 | Edwards, B.F.P, Huettemann, M, Vaishnav, A, Brunzelle, J, Morse, P, Wan, J. | 登録日 | 2022-07-30 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle. Nat Commun, 14, 2023
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8DZL
| Structure of the K39Q mutant of rat somatic Cytochrome c at 1.36A | 分子名称: | Cytochrome c, somatic, HEME C | 著者 | Edwards, B.F.P, Huettemann, M, Vaishnav, A, Brunzelle, J, Morse, P, Wan, J. | 登録日 | 2022-08-08 | 公開日 | 2023-07-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle. Nat Commun, 14, 2023
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8E1G
| SARS-CoV-2 RBD in complex with Omicron-neutralizing antibody 2A10 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2A10 Fab, heavy chain, ... | 著者 | Wasserman, H, Hastie, K.M, Buck, T.K, Saphire, E.O. | 登録日 | 2022-08-10 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep, 42, 2023
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6NE5
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8F0G
| Structure of SARS-CoV-2 Omicron BA.1 spike in complex with antibody Fab 1C3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 1C3 Fab Heavy Chain, ... | 著者 | Yu, X, Zyla, D, Hastie, K.M, Saphire, E.O. | 登録日 | 2022-11-02 | 公開日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep, 42, 2023
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8F0H
| Structure of SARS-CoV-2 spike with antibody Fabs 2A10 and 1H2 (Local refinement of the RBD and Fabs 1H2 and 2A10) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 1H2 heavy chain, Antibody Fab 1H2 light chain, ... | 著者 | Yu, X, Zyla, D, Hastie, K.M, Saphire, E.O. | 登録日 | 2022-11-02 | 公開日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep, 42, 2023
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6KL7
| Beta-arrestin 1 mutant S13D/T275D | 分子名称: | 1,2-ETHANEDIOL, BARIUM ION, Beta-arrestin-1 | 著者 | Kang, H, Choi, H.J. | 登録日 | 2019-07-29 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | 主引用文献 | Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins. Structure, 28, 2020
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7MU5
| Human DCTPP1 bound to Triptolide | 分子名称: | MAGNESIUM ION, dCTP pyrophosphatase 1, triptolide | 著者 | Hauk, G, Berger, J.M. | 登録日 | 2021-05-14 | 公開日 | 2022-08-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance To Be Published
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4ZKJ
| Crystal structure of CRISPR-associated protein | 分子名称: | CRISPR-associated protein Cas1, GLYCEROL | 著者 | Ka, D, Bae, E. | 登録日 | 2015-04-30 | 公開日 | 2016-01-13 | 最終更新日 | 2016-01-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal Structure of Streptococcus pyogenes Cas1 and Its Interaction with Csn2 in the Type II CRISPR-Cas System Structure, 24, 2016
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3ACD
| Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with IMP from Thermus thermophilus HB8 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Hypoxanthine-guanine phosphoribosyltransferase, INOSINIC ACID | 著者 | Kanagawa, M, Baba, S, Hirotsu, K, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2009-12-30 | 公開日 | 2010-02-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Structures of hypoxanthine-guanine phosphoribosyltransferase (TTHA0220) from Thermus thermophilus HB8. Acta Crystallogr.,Sect.F, 66, 2010
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3ACC
| Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with GMP from Thermus thermophilus HB8 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, GUANOSINE-5'-MONOPHOSPHATE, Hypoxanthine-guanine phosphoribosyltransferase | 著者 | Kanagawa, M, Baba, S, Hirotsu, K, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2009-12-30 | 公開日 | 2010-02-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Structures of hypoxanthine-guanine phosphoribosyltransferase (TTHA0220) from Thermus thermophilus HB8. Acta Crystallogr.,Sect.F, 66, 2010
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