8XK2
 
 | | A neutralizing nanobody VHH60 against wt SARS-CoV-2 | | 分子名称: | Spike protein S1, VHH60 nanobody | | 著者 | Lu, Y, Guo, H, Ji, X, Yang, H. | | 登録日 | 2023-12-22 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug.
Cell Death Dis, 15, 2024
|
|
8XKI
 | | A neutralizing nanobody VHH60 against wt SARS-CoV-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Lu, Y, Guo, H, Ji, X, Yang, H. | | 登録日 | 2023-12-23 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug.
Cell Death Dis, 15, 2024
|
|
8W5C
 | | Crystal structure of FGFR4 kinase domain in complex with 8K | | 分子名称: | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-6-[(4-methylpiperazin-1-yl)methyl]-1-propan-2-yl-pyrrolo[3,2-b]pyridine-3-carboxamide | | 著者 | Zhang, Z.M, Huang, H.S. | | 登録日 | 2023-08-26 | | 公開日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
J.Med.Chem., 67, 2024
|
|
8WA3
 | | Cryo-EM structure of peptide free and Gs-coupled GIPR | | 分子名称: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | 登録日 | 2023-09-06 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
|
|
7XPQ
 | |
8WG8
 | | Cryo-EM structures of peptide free and Gs-coupled GCGR | | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | 登録日 | 2023-09-20 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
|
|
8WG7
 | | Cryo-EM structures of peptide free and Gs-coupled GLP-1R | | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | 登録日 | 2023-09-20 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
|
|
7XPO
 | | Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD/UDP-Glc | | 分子名称: | GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase, ... | | 著者 | Chen, Y.H, Wang, X.C, Zhang, C.R. | | 登録日 | 2022-05-05 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis.
Nat Commun, 14, 2023
|
|
7XPP
 | |
8IMS
 | | Crystal structure of TRAF7 coiled-coil domain | | 分子名称: | E3 ubiquitin-protein ligase TRAF7 | | 著者 | Hu, R, Lin, L, Lu, Q. | | 登録日 | 2023-03-07 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development.
J Mol Cell Biol, 16, 2024
|
|
7X1G
 | |
7X1H
 | |
7X1J
 | | Cryo-EM structure of human BTR1 in the outward-facing state in the presence of NH4Cl. | | 分子名称: | Isoform 1 of Solute carrier family 4 member 11, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | | 著者 | Yin, Y, Lu, Y, Zuo, P. | | 登録日 | 2022-02-24 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP 2.
Nat Commun, 14, 2023
|
|
7X1I
 | | Cryo-EM structure of human BTR1 in the outward-facing state. | | 分子名称: | Isoform 1 of Solute carrier family 4 member 11, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | | 著者 | Yin, Y, Lu, Y, Zuo, P. | | 登録日 | 2022-02-24 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP 2.
Nat Commun, 14, 2023
|
|
5VFC
 | | WDR5 bound to inhibitor MM-589 | | 分子名称: | 1,2-ETHANEDIOL, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ... | | 著者 | Stuckey, J.A. | | 登録日 | 2017-04-07 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 60, 2017
|
|
7YHK
 | | Cryo-EM structure of the HA trimer of A/Beijing/262/1995(H1N1) in complex with neutralizing antibody 12H5 | | 分子名称: | 12H5 heavy chain, 12H5 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zheng, Q, Li, S, Li, T, Xue, W, Sun, H. | | 登録日 | 2022-07-13 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses.
Nat Commun, 13, 2022
|
|
8KEE
 | |
8KEA
 | | Cyanophage A-1(L) baseplate-initiators | | 分子名称: | baseplate gp16, central spike, hub, ... | | 著者 | Yu, R.C, Li, Q, Zhou, C.Z. | | 登録日 | 2023-08-11 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Structure of the intact tail machine of Anabaena myophage A-1(L).
Nat Commun, 15, 2024
|
|
6CPU
 | | Crystal structure of yeast caPDE2 | | 分子名称: | MAGNESIUM ION, Phosphodiesterase, ZINC ION | | 著者 | Ke, H, Wang, y. | | 登録日 | 2018-03-14 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions.
Biochemistry, 57, 2018
|
|
8KE9
 | |
8KEC
 | |
8SX9
 | |
8SX8
 | |
8SXB
 | |
8SX7
 | |
