5VFC

WDR5 bound to inhibitor MM-589

Summary for 5VFC

Entry DOI	10.2210/pdb5vfc/pdb
Related PRD ID	PRD_002270
Descriptor	WD repeat-containing protein 5, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	inhibitor, complex, wd repeat, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35336.08
Authors	Stuckey, J.A. (deposition date: 2017-04-07, release date: 2017-06-28, Last modification date: 2024-03-13)
Primary citation	Karatas, H.,Li, Y.,Liu, L.,Ji, J.,Lee, S.,Chen, Y.,Yang, J.,Huang, L.,Bernard, D.,Xu, J.,Townsend, E.C.,Cao, F.,Ran, X.,Li, X.,Wen, B.,Sun, D.,Stuckey, J.A.,Lei, M.,Dou, Y.,Wang, S. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J. Med. Chem., 60:4818-4839, 2017 Cited by PubMed: 28603984 DOI: 10.1021/acs.jmedchem.6b01796 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation