5VFC

WDR5 bound to inhibitor MM-589

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	APS BEAMLINE 21-ID-F
Synchrotron site	APS
Beamline	21-ID-F
Temperature [K]	100
Detector technology	CCD
Collection date	2016-11-29
Detector	RAYONIX MX300-HS
Wavelength(s)	0.9787
Spacegroup name	C 1 2 1
Unit cell lengths	88.348, 58.559, 56.801
Unit cell angles	90.00, 96.16, 90.00

Refinement procedure

Resolution	15.550 - 1.640
R-factor	0.149
Rwork	0.148
R-free	0.17400
RMSD bond length	0.010
RMSD bond angle	1.140
Data reduction software	HKL-2000
Data scaling software	HKL-2000
Phasing software	MOLREP
Refinement software	BUSTER (2.10.2)

Data quality characteristics

	Overall
Low resolution limit [Å]	15.550
High resolution limit [Å]	1.640
Rmerge	0.063
Number of reflections	35269
<I/σ(I)>	10
Completeness [%]	99.9
Redundancy	6.9

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	0.1 M Na Bis-Tris pH 6.5, 26% PEG 8000 and 0.1 M ammonium sulfate