7N32
 
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7MWG
 | | 16-nm repeat microtubule doublet | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Rao, Q, Zhang, K. | | 登録日 | 2021-05-17 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism.
Nat.Struct.Mol.Biol., 28, 2021
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7E5R
 | | SARS-CoV-2 S trimer with three-antibody cocktail complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FC05 heavy chain, FC05 light chain, ... | | 著者 | Sun, Y, Wang, L, Wang, N, Feng, R, Wang, X. | | 登録日 | 2021-02-20 | | 公開日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms.
Cell Res., 31, 2021
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7E5S
 | | SARS-CoV-2 S trimer with four-antibody cocktail complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FC05 heavy chain, FC05 light chain, ... | | 著者 | Sun, Y, Wang, L, Wang, N, Feng, R, Wang, X. | | 登録日 | 2021-02-20 | | 公開日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms.
Cell Res., 31, 2021
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5J9K
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) in complex with rice D53 repressor EAR peptide motif | | 分子名称: | Protein TPR1, ZINC ION, rice D53 peptide 794-808 | | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | 登録日 | 2016-04-10 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
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9BIG
 | | Stat6 bound to degrader AK-1690 | | 分子名称: | Signal transducer and activator of transcription 6, [(2-{[(2S)-1-{(2S,4S)-4-[(7-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}hept-6-yn-1-yl)oxy]-2-[(2R)-2-phenylmorpholine-4-carbonyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-1-benzothiophen-5-yl)di(fluoro)methyl]phosphonic acid | | 著者 | Mallik, L, Stuckey, J.A. | | 登録日 | 2024-04-23 | | 公開日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (3.304 Å) | | 主引用文献 | Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader.
J.Med.Chem., 2024
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5GZE
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7N61
 | | structure of C2 projections and MIPs | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FAP147, FAP178, ... | | 著者 | Han, L, Zhang, K. | | 登録日 | 2021-06-07 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
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7N6G
 | | C1 of central pair | | 分子名称: | CPC1, Calmodulin, DPY30, ... | | 著者 | Han, L, Zhang, K. | | 登録日 | 2021-06-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
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6M3B
 | | hAPC-c25k23 Fab complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, ... | | 著者 | Wang, X, Li, L, Zhao, X, Egner, U. | | 登録日 | 2020-03-03 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.
Nat Commun, 11, 2020
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7WRO
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7WR8
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7WRL
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7WRZ
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5JGC
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A, L130A, L179A and I195A mutant | | 分子名称: | Protein TPR1, ZINC ION | | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | 登録日 | 2016-04-20 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
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4GG5
 | | Crystal structure of CMET in complex with novel inhibitor | | 分子名称: | 3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine, Hepatocyte growth factor receptor | | 著者 | Liu, Q.F, Chen, T.T, Xu, Y.C. | | 登録日 | 2012-08-05 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.423 Å) | | 主引用文献 | Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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4GG7
 | | Crystal structure of cMET in complex with novel inhibitor | | 分子名称: | Hepatocyte growth factor receptor, N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine | | 著者 | Liu, Q.F, Chen, T.T, Xu, Y.C. | | 登録日 | 2012-08-06 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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4IN0
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6J0N
 | | Cryo-EM Structure of an Extracellular Contractile Injection System, baseplate in extended state, refined in C6 symmetry | | 分子名称: | Pvc1, Pvc11, Pvc12, ... | | 著者 | Jiang, F, Li, N, Wang, X, Cheng, J, Huang, Y, Yang, Y, Yang, J, Cai, B, Wang, Y, Jin, Q, Gao, N. | | 登録日 | 2018-12-25 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System.
Cell, 177, 2019
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6J0M
 | | Cryo-EM Structure of an Extracellular Contractile Injection System, PVC baseplate in extended state (reconstructed with C3 symmetry) | | 分子名称: | Pvc8 | | 著者 | Jiang, F, Li, N, Wang, X, Cheng, J, Huang, Y, Yang, Y, Yang, J, Cai, B, Wang, Y, Jin, Q, Gao, N. | | 登録日 | 2018-12-24 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System.
Cell, 177, 2019
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7CWS
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2IGL
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8XRU
 | | The crystal structure of a GH3 enzyme CcBgl3B with glycerol | | 分子名称: | CALCIUM ION, GH3 enzyme CcBgl3B, GLYCEROL | | 著者 | Su, J.Y. | | 登録日 | 2024-01-08 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | A trapped covalent intermediate as a key catalytic element in the hydrolysis of a GH3 beta-glucosidase: An X-ray crystallographic and biochemical study.
Int.J.Biol.Macromol., 265, 2024
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8XRX
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8XRT
 | | The crystal structure of a GH3 enzyme CcBgl3B | | 分子名称: | CALCIUM ION, GH3 enzyme CcBgl3B | | 著者 | Su, J.Y. | | 登録日 | 2024-01-08 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A trapped covalent intermediate as a key catalytic element in the hydrolysis of a GH3 beta-glucosidase: An X-ray crystallographic and biochemical study.
Int.J.Biol.Macromol., 265, 2024
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