6M3B

hAPC-c25k23 Fab complex

Summary for 6M3B

• Entry DOI: 10.2210/pdb6m3b/pdb
• Descriptor: Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, c25k23 Fab L chain, ... (6 entities in total)
• Functional Keywords: human apc, c25k23 fab, complex, blood clotting, blood clotting-immune system complex, blood clotting/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 92505.03

Authors

Wang, X.,Li, L.,Zhao, X.,Egner, U. (deposition date: 2020-03-03, release date: 2020-07-08, Last modification date: 2023-11-29)

• Primary citation: Zhao, X.Y.,Wilmen, A.,Wang, D.,Wang, X.,Bauzon, M.,Kim, J.Y.,Linden, L.,Li, L.,Egner, U.,Marquardt, T.,Moosmayer, D.,Tebbe, J.,Gluck, J.M.,Ellinger, P.,McLean, K.,Yuan, S.,Yegneswaran, S.,Jiang, X.,Evans, V.,Gu, J.M.,Schneider, D.,Zhu, Y.,Xu, Y.,Mallari, C.,Hesslein, A.,Wang, Y.,Schmidt, N.,Gutberlet, K.,Ruehl-Fehlert, C.,Freyberger, A.,Hermiston, T.,Patel, C.,Sim, D.,Mosnier, L.O.,Laux, V.; Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.; Nat Commun, 11:2992-2992, 2020; PubMed: 32532974; DOI: 10.1038/s41467-020-16720-9

Experimental method

X-RAY DIFFRACTION (2.2 Å)