6X3S
 
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide | | 分子名称: | (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | | 登録日 | 2020-05-21 | | 公開日 | 2020-09-09 | | 最終更新日 | 2020-09-23 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
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6WZ8
 | | Complex of Pseudomonas 7A Glutaminase-Asparaginase with Citrate Anion at pH 5.5. Covalent Acyl-Enzyme Intermediate | | 分子名称: | CITRIC ACID, Glutaminase-asparaginase | | 著者 | Strzelczyk, P, Zhang, D, Wlodawer, A, Lubkowski, J. | | 登録日 | 2020-05-13 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Generalized enzymatic mechanism of catalysis by tetrameric L-asparaginases from mesophilic bacteria.
Sci Rep, 10, 2020
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4MVK
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3MXO
 | | Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5) | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Chaikuad, A, Alfano, I, Picaud, S, Filippakopoulos, P, Barr, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Takeda, K, Ichijo, H, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2010-05-07 | | 公開日 | 2010-09-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.
Structure, 25, 2017
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6WFS
 | | Cryo-EM Structure of Hepatitis B virus T=4 capsid in complex with the antiviral molecule DBT1 | | 分子名称: | 11-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide, Capsid protein | | 著者 | Schlicksup, C, Laughlin, P, Dunkelbarger, S, Wang, J.C, Zlotnick, A. | | 登録日 | 2020-04-03 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Local Stabilization of Subunit-Subunit Contacts Causes Global Destabilization of Hepatitis B Virus Capsids.
Acs Chem.Biol., 15, 2020
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6TI5
 | | A New Structural Model of Abeta(1-40) Fibrils | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Bertini, I, Gonnelli, L, Luchinat, C, Mao, J, Nesi, A. | | 登録日 | 2019-11-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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6WGJ
 | | Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide | | 分子名称: | Dupilumab Fab heavy chain, Dupilumab Fab light chain | | 著者 | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | | 登録日 | 2020-04-05 | | 公開日 | 2020-09-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6WGP
 | | The crystal structure of a beta lactamase from Xanthomonas campestris pv. campestris str. ATCC 33913 | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase, ... | | 著者 | Tan, K, Wu, R, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-04-06 | | 公開日 | 2020-04-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The crystal structure of a beta lactamase from Xanthomonas campestris pv. campestris str. ATCC 33913
To Be Published
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7UVE
 | | Drosophila melanogaster setdb1-tuor domain with peptide H3K9me2K14ac | | 分子名称: | Histone-lysine N-methyltransferase eggless, peptide H3K9me2K14ac | | 著者 | Zhou, M, Dong, A, Liu, K, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2022-05-01 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Drosophila melanogaster setdb1-tuor domain with peptide H3K9me2K14ac
To Be Published
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7UW8
 | | Drosophila melanogaster setdb1-tuor domain | | 分子名称: | Histone-lysine N-methyltransferase eggless | | 著者 | Zhou, M, Dong, A, Liu, K, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2022-05-03 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Drosophila melanogaster setdb1-tuor domain
To Be Published
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6TI6
 | | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | | 登録日 | 2019-11-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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6WMA
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6WMC
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7UOH
 | | PRMT5/MEP50 crystal structure with MTA and an achiral, class 1, non-atropisomeric inhibitor bound | | 分子名称: | (2M)-2-[(4M)-4-{4-(aminomethyl)-1-oxo-8-[(2R)-oxolan-2-yl]-1,2-dihydrophthalazin-6-yl}-1-methyl-1H-pyrazol-5-yl]-1-benzothiophene-3-carbonitrile, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... | | 著者 | Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. | | 登録日 | 2022-04-12 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.
Bioorg.Med.Chem., 71, 2022
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3MVG
 | | Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A | | 分子名称: | GLYCEROL, Ribosome inactivating type 1 protein, SULFATE ION | | 著者 | Meyer, A, Weber, W, Singh, T.P, Betzel, C. | | 登録日 | 2010-05-04 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A
to be published
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6X3W
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, ... | | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | | 登録日 | 2020-05-21 | | 公開日 | 2020-09-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
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6U87
 | | Pseudomonas aeruginosa HasA mutant - Y75H | | 分子名称: | HasAp, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Brimberry, M, Lanzilotta, W, Wilks, A, Dent, A. | | 登録日 | 2019-09-04 | | 公開日 | 2020-09-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Axial Heme Coordination by the Tyr-His Motif in the Extracellular Hemophore HasAp Is Critical for the Release of Heme to the HasR Receptor of Pseudomonas aeruginosa .
Biochemistry, 60, 2021
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6WZ3
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2O6B
 | | Crystal structure of the PA5185 protein from Pseudomonas Aeruginosa strain PAO1- new crystal form. | | 分子名称: | THIOESTERASE | | 著者 | Chruszcz, M, Koclega, K.D, Evdokimova, E, Cymborowski, M, Kudritska, M, Savchenko, A, Edwards, A, Minor, W. | | 登録日 | 2006-12-07 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1.
Cryst.Growth Des., 8, 2008
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2O5E
 | | Structure of E. coli topoisomerase III in complex with an 8-base single stranded oligonucleotide. Frozen in glucose pH 7.0 | | 分子名称: | 5'-D(*CP*GP*CP*AP*AP*CP*TP*T)-3', CHLORIDE ION, DNA topoisomerase 3, ... | | 著者 | Changela, A, DiGate, R.J, Mondragon, A. | | 登録日 | 2006-12-05 | | 公開日 | 2007-04-03 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate.
J.Mol.Biol., 368, 2007
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2O8P
 | | Crystal structure of a putative 14-3-3 protein from Cryptosporidium parvum, cgd7_2470 | | 分子名称: | 14-3-3 domain containing protein | | 著者 | Dong, A, Lew, J, Wasney, G, Lin, L, Hassanali, A, Zhao, Y, Vedadi, M, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Walker, J.R, Bochkarev, A, Hui, R, Brokx, S.J, Structural Genomics Consortium (SGC) | | 登録日 | 2006-12-12 | | 公開日 | 2007-01-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Characterization of 14-3-3 proteins from Cryptosporidium parvum.
Plos One, 6, 2011
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6WNJ
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6WT8
 | | Structure of a STING-associated CdnE c-di-GMP synthase from Flavobacteriaceae sp. | | 分子名称: | STING-associated CdnE c-di-GMP synthase | | 著者 | Morehouse, B.R, Govande, A.A, Millman, A, Keszei, A.F.A, Lowey, B, Ofir, G, Shao, S, Sorek, R, Kranzusch, P.J. | | 登録日 | 2020-05-01 | | 公開日 | 2020-09-09 | | 最終更新日 | 2020-10-28 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | STING cyclic dinucleotide sensing originated in bacteria.
Nature, 586, 2020
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7TPI
 | | SARS-CoV-2 E406W mutant Spike ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Addetia, A, Veesler, D. | | 登録日 | 2022-01-25 | | 公開日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | SARS-CoV-2 E406W mutant Spike ectodomain
To Be Published
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6WYX
 | | Crystal structure of Pseudomonas 7A Glutaminase-Asparaginase in complex with L-Asp at pH 5.0 | | 分子名称: | ASPARTIC ACID, GLYCEROL, Glutaminase-asparaginase | | 著者 | Strzelczyk, P, Zhang, D, Wlodawer, A, Lubkowski, J. | | 登録日 | 2020-05-13 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Generalized enzymatic mechanism of catalysis by tetrameric L-asparaginases from mesophilic bacteria.
Sci Rep, 10, 2020
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