6WFS
Cryo-EM Structure of Hepatitis B virus T=4 capsid in complex with the antiviral molecule DBT1
Summary for 6WFS
| Entry DOI | 10.2210/pdb6wfs/pdb |
| EMDB information | 21653 21654 21655 |
| Descriptor | Capsid protein, 11-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide (2 entities in total) |
| Functional Keywords | capsid, antiviral, hbv, virus like particle |
| Biological source | Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) |
| Total number of polymer chains | 4 |
| Total formula weight | 68978.55 |
| Authors | Schlicksup, C.,Laughlin, P.,Dunkelbarger, S.,Wang, J.C.,Zlotnick, A. (deposition date: 2020-04-03, release date: 2020-06-03, Last modification date: 2024-03-06) |
| Primary citation | Schlicksup, C.J.,Laughlin, P.,Dunkelbarger, S.,Wang, J.C.,Zlotnick, A. Local Stabilization of Subunit-Subunit Contacts Causes Global Destabilization of Hepatitis B Virus Capsids. Acs Chem.Biol., 15:1708-1717, 2020 Cited by PubMed: 32369333DOI: 10.1021/acschembio.0c00320 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4.6 Å) |
Structure validation
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