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5FFO
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BU of 5ffo by Molmil
Integrin alpha V beta 6 in complex with pro-TGF-beta
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Dong, X, Zhao, B, Springer, T.A.
登録日2015-12-18
公開日2017-01-25
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.49 Å)
主引用文献Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
6ASK
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BU of 6ask by Molmil
Crystal Structure of apo Flavin monooxygenase CmoJ (earlier YtnJ)
分子名称: Putative monooxygenase MoxC
著者Bhandari, D.M, Zhao, B, Li, P, Begley, T.P.
登録日2017-08-24
公開日2018-08-29
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Flavin mediated Pummerer type rearrangement in cysteine salvage pathway
To Be Published
6ASL
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BU of 6asl by Molmil
Crystal Structure of Flavin monooxygenase CmoJ (earlier YtnJ) bound with FMN
分子名称: FLAVIN MONONUCLEOTIDE, LUMIFLAVIN, Putative monooxygenase MoxC
著者Bhandari, D.M, Zhao, B, Li, P, Begley, T.P.
登録日2017-08-24
公開日2018-09-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Flavin mediated Pummerer type rearrangement in cysteine salvage pathway
To Be Published
6NM8
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BU of 6nm8 by Molmil
IgV-V76T BMS compound 105
分子名称: N-({2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl}methyl)-D-alanine, Programmed cell death 1 ligand 1
著者Perry, E, Zhao, B, Fesik, S.
登録日2019-01-10
公開日2019-02-20
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.792 Å)
主引用文献Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
6NM7
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BU of 6nm7 by Molmil
PD-L1 IgV domain bound to fragment
分子名称: 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one, Programmed cell death 1 ligand 1
著者Perry, E, Zhao, B.
登録日2019-01-10
公開日2019-02-20
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.426 Å)
主引用文献Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
2LGG
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BU of 2lgg by Molmil
Structure of PHD domain of UHRF1 in complex with H3 peptide
分子名称: E3 ubiquitin-protein ligase UHRF1, ZINC ION, histone H3 peptide
著者Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C.
登録日2011-07-26
公開日2011-09-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
2LUH
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BU of 2luh by Molmil
NMR structure of the Vta1-Vps60 complex
分子名称: Vacuolar protein sorting-associated protein VTA1, Vacuolar protein-sorting-associated protein 60
著者Yang, Z, Vild, C, Ju, J, Zhang, X, Liu, J, Shen, J, Zhao, B, Lan, W, Gong, F, Liu, M, Cao, C, Xu, Z.
登録日2012-06-13
公開日2012-11-07
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Basis of Molecular Recognition between ESCRT-III-like Protein Vps60 and AAA-ATPase Regulator Vta1 in the Multivesicular Body Pathway.
J.Biol.Chem., 287, 2012
2LGK
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BU of 2lgk by Molmil
NMR Structure of UHRF1 PHD domains in a complex with histone H3 peptide
分子名称: E3 ubiquitin-protein ligase UHRF1, ZINC ION, histone H3 peptide
著者Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C.
登録日2011-07-28
公開日2011-09-28
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
2LGL
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BU of 2lgl by Molmil
NMR structure of the UHRF1 PHD domain
分子名称: E3 ubiquitin-protein ligase UHRF1, ZINC ION
著者Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C.
登録日2011-07-28
公開日2011-09-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
6ATV
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BU of 6atv by Molmil
The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions
分子名称: Adapter molecule crk, proline-rich motif in IAV-NS1
著者Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H.
登録日2017-08-29
公開日2018-08-08
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献Molecular Mechanisms of Tight Binding through Fuzzy Interactions.
Biophys. J., 114, 2018
4HW4
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BU of 4hw4 by Molmil
Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 BH3 peptide
著者Friberg, A, Zhao, B.
登録日2012-11-07
公開日2013-01-09
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
7U4A
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BU of 7u4a by Molmil
Crystal Structure of Zika virus xrRNA1 mutant
分子名称: MAGNESIUM ION, RNA (70-MER)
著者Thompson, R.D, Carbaugh, D.L, Nielsen, J.R, Witt, C, Meganck, R.M, Rangadurai, A, Zhao, B, Bonin, J.P, Nathan, N.T, Marzluff, W.F, Frank, A.T, Lazear, H.M, Zhang, Q.
登録日2022-02-28
公開日2023-09-06
最終更新日2025-03-19
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Lifetime of ground conformational state determines the activity of structured RNA.
Nat.Chem.Biol., 2025
5JEJ
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BU of 5jej by Molmil
Phosphorylated STING in complex with IRF-3 CTD
分子名称: Interferon regulatory factor 3, Stimulator of interferon genes protein
著者Li, P, Shu, C.
登録日2016-04-18
公開日2016-06-15
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
6X59
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BU of 6x59 by Molmil
The mouse cGAS catalytic domain binding to human assembled nucleosome
分子名称: Cyclic GMP-AMP synthase, DNA, Histone H2A type 1, ...
著者Pengbiao, X, Pingwei, L, Baoyu, Z.
登録日2020-05-25
公開日2020-09-16
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献The molecular basis of tight nuclear tethering and inactivation of cGAS.
Nature, 587, 2020
6X5A
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BU of 6x5a by Molmil
The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells
分子名称: Cyclic GMP-AMP synthase, DNA (natural), Histone H2A type 1, ...
著者Pengbiao, X, Pingwei, L, Baoyu, Z.
登録日2020-05-25
公開日2020-09-16
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (4.36 Å)
主引用文献The molecular basis of tight nuclear tethering and inactivation of cGAS.
Nature, 587, 2020
5OB5
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BU of 5ob5 by Molmil
fAb complex with GroBeta. AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery.
分子名称: C-X-C motif chemokine 2, GLYCEROL, SULFATE ION, ...
著者Zhao, B, Ward, P, Convery, M.A.
登録日2017-06-26
公開日2017-11-08
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery
To Be Published
4ISN
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BU of 4isn by Molmil
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
分子名称: GLUTATHIONE, Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, ...
著者Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
登録日2013-01-16
公開日2013-03-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4IS5
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BU of 4is5 by Molmil
Crystal Structure of the ligand-free inactive Matriptase
分子名称: GLUTATHIONE, GLYCEROL, SULFATE ION, ...
著者Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
登録日2013-01-16
公開日2013-03-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4ISO
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BU of 4iso by Molmil
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
分子名称: DI(HYDROXYETHYL)ETHER, GLUTATHIONE, GLYCEROL, ...
著者Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
登録日2013-01-16
公開日2013-03-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4ISL
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BU of 4isl by Molmil
Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1
分子名称: GLUTATHIONE, GLYCEROL, Kunitz-type protease inhibitor 1, ...
著者Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
登録日2013-01-16
公開日2013-03-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
8VLV
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BU of 8vlv by Molmil
Cryo-EM structure of human HGSNAT in inactive state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heparan-alpha-glucosaminide N-acetyltransferase
著者Li, F.
登録日2024-01-12
公開日2024-06-26
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome.
Nat Commun, 15, 2024
8IUY
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BU of 8iuy by Molmil
H7N9 HA-1H9 Fab
分子名称: 1H9 Fab heavy chain, 1H9 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, B.B, Sun, Z.Z.
登録日2023-03-25
公開日2024-04-24
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of different neutralization capabilities of monoclonal antibodies against H7N9 virus.
J.Virol., 99, 2025
8IUZ
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BU of 8iuz by Molmil
H7N9 HA-2D7 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2D7 Fab heavy chain, 2D7 Fab light chain, ...
著者Zhao, B.B, Sun, Z.Z.
登録日2023-03-25
公開日2024-04-24
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of different neutralization capabilities of monoclonal antibodies against H7N9 virus.
J.Virol., 99, 2025
8IUX
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BU of 8iux by Molmil
The cryoEM structure of H7N9-HA protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin
著者Zhao, B.B, Sun, Z.Z.
登録日2023-03-25
公開日2024-04-24
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of different neutralization capabilities of monoclonal antibodies against H7N9 virus.
J.Virol., 99, 2025
8IV0
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BU of 8iv0 by Molmil
H7N9 HA-C4H4 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C4H4 Fab heavy chain, C4H4 Fab light chain, ...
著者Zhao, B.B, Sun, Z.Z.
登録日2023-03-25
公開日2024-04-24
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of different neutralization capabilities of monoclonal antibodies against H7N9 virus.
J.Virol., 99, 2025

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