7EFR
 
 | | Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | | 著者 | Lu, G.W, Ye, F, Lin, X. | | 登録日 | 2021-03-23 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | | 主引用文献 | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis.
Signal Transduct Target Ther, 6, 2021
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8HJ2
 | | GPR21 wt with G15 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Chen, B, Lin, X, Xu, F. | | 登録日 | 2022-11-22 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes.
Nat Commun, 14, 2023
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8HIX
 | | Cryo-EM structure of GPR21_m5_Gs | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Chen, B, Lin, X, Xu, F. | | 登録日 | 2022-11-22 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes.
Nat Commun, 14, 2023
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8HJ0
 | | GPR21(m5) and G15 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Chen, B, Lin, X. | | 登録日 | 2022-11-22 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes.
Nat Commun, 14, 2023
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8HJ1
 | | GPR21(wt) and Gs complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Chen, B, Lin, X, Xu, F. | | 登録日 | 2022-11-22 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes.
Nat Commun, 14, 2023
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8GVK
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7WKX
 | | IL-17A in complex with the humanized antibody HB0017 | | 分子名称: | ACETIC ACID, Heavy chain of HB0017 Fab, Interleukin-17A, ... | | 著者 | Xu, J, Zhu, X, He, Y. | | 登録日 | 2022-01-12 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases.
Int.J.Biol.Macromol., 202, 2022
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6ILC
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6ILE
 | | CRYSTAL STRUCTURE OF A MUTANT PTAL-N*01:01 FOR 2.9 ANGSTROM, 52M 53D 54L DELETED | | 分子名称: | Beta-2-microglobulin, HEV-1, MHC class I antigen | | 著者 | Qu, Z.H, Zhang, N.Z, Xia, C. | | 登録日 | 2018-10-17 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding.
J Immunol., 202, 2019
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6ILF
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6ILG
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8HS2
 | | Orphan GPR20 in complex with Fab046 | | 分子名称: | Light chain of Fab046, Soluble cytochrome b562,G-protein coupled receptor 20, heavy chain of Fab046 | | 著者 | Lin, X, Jiang, S, Xu, F. | | 登録日 | 2022-12-16 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20.
Cell Discov, 9, 2023
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8HS3
 | | Gi bound orphan GPR20 in ligand-free state | | 分子名称: | Ggama, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Lin, X, Jiang, S, Xu, F. | | 登録日 | 2022-12-16 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20.
Cell Discov, 9, 2023
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8HSC
 | | Gi bound Orphan GPR20 complex with Fab046 in ligand-free state | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Lin, X, Jiang, S, Xu, F. | | 登録日 | 2022-12-19 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20.
Cell Discov, 9, 2023
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7DWC
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6NZN
 | | Dimer-of-dimer amyloid fibril structure of glucagon | | 分子名称: | Glucagon | | 著者 | Gelenter, M.D, Smith, K.J, Liao, S.Y, Mandala, V.S, Dregni, A.J, Lamm, M.S, Tian, Y, Wei, X, Pochan, D.J, Tucker, T.J, Su, Y, Hong, M. | | 登録日 | 2019-02-14 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | The peptide hormone glucagon forms amyloid fibrils with two coexisting beta-strand conformations.
Nat.Struct.Mol.Biol., 26, 2019
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7XGY
 | | cryo-EM structure of hemoglobin | | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Liu, N, Wang, H.W. | | 登録日 | 2022-04-07 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Uniform thin ice on ultraflat graphene for high-resolution cryo-EM.
Nat.Methods, 20, 2023
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7WBO
 | | Crystal structure of Sarcoplasmic Calcium-Binding Protein from Scylla paramamosain | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, SODIUM ION, ... | | 著者 | Chen, Y, Jin, T, Liu, G. | | 登録日 | 2021-12-17 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure Analysis of Sarcoplasmic-Calcium-Binding Protein: An Allergen in Scylla paramamosain.
J.Agric.Food Chem., 71, 2023
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7YAC
 | | Paltusotine-bound SSTR2-Gi complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Zhao, J, Shao, Z. | | 登録日 | 2022-06-27 | | 公開日 | 2023-04-19 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine.
Nat Commun, 14, 2023
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7YAE
 | | Octreotide-bound SSTR2-Gi complex | | 分子名称: | CHOLESTEROL, DPN-CYS-PHE-DTR-LYS-THR-CYS-THO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Zhao, J, Shao, Z. | | 登録日 | 2022-06-28 | | 公開日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine.
Nat Commun, 14, 2023
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7XRV
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7XRT
 | | Bacteroides thetaiotaomicron ferulic acid esterase (BT_4077) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Ferulic acid esterase | | 著者 | Du, G.M, Wang, Y.L, Xin, F.J. | | 登録日 | 2022-05-11 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.007 Å) | | 主引用文献 | Structural insights into the oligomeric effects on catalytic activity of a decameric feruloyl esterase and its application in ferulic acid production.
Int.J.Biol.Macromol., 253, 2023
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7DMB
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7EBO
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7L1K
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