7M5O
| Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA | 分子名称: | CasPhi, ZINC ION, crRNA | 著者 | Pausch, P, Soczek, K, Nogales, E, Doudna, J. | 登録日 | 2021-03-24 | 公開日 | 2021-08-04 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | DNA interference states of the hypercompact CRISPR-Cas Phi effector. Nat.Struct.Mol.Biol., 28, 2021
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6HVF
| Kinase domain of cSrc in complex with compound 29B | 分子名称: | 1,2-ETHANEDIOL, Proto-oncogene tyrosine-protein kinase Src, ~{N}-[3-[3-ethyl-6-[4-(4-methylpiperazin-1-yl)phenyl]-4-oxidanylidene-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide | 著者 | Keul, M, Mueller, M.P, Rauh, D. | 登録日 | 2018-10-10 | 公開日 | 2019-10-23 | 最終更新日 | 2020-01-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S. Chem Sci, 10, 2019
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6HVE
| Kinase domain of cSrc in complex with compound 9 | 分子名称: | Proto-oncogene tyrosine-protein kinase Src, ~{N}-[3-(4-methoxy-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]prop-2-enamide | 著者 | Keul, M, Mueller, M.P, Rauh, D. | 登録日 | 2018-10-10 | 公開日 | 2019-10-23 | 最終更新日 | 2020-01-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S. Chem Sci, 10, 2019
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1LFT
| OXY HEMOGLOBIN (90% RELATIVE HUMIDITY) | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Biswal, B.K, Vijayan, M. | 登録日 | 2002-04-12 | 公開日 | 2002-10-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state. Acta Crystallogr.,Sect.D, 58, 2002
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1LFZ
| OXY HEMOGLOBIN (25% METHANOL) | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Biswal, B.K, Vijayan, M. | 登録日 | 2002-04-12 | 公開日 | 2002-10-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state. Acta Crystallogr.,Sect.D, 58, 2002
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1LFQ
| OXY HEMOGLOBIN (93% RELATIVE HUMIDITY) | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Biswal, B.K, Vijayan, M. | 登録日 | 2002-04-12 | 公開日 | 2002-10-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state. Acta Crystallogr.,Sect.D, 58, 2002
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7LYS
| Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and DNA | 分子名称: | CasPhi-2, NTS-DNA, TS-DNA, ... | 著者 | Pausch, P, Soczek, K, Nogales, E, Doudna, J. | 登録日 | 2021-03-08 | 公開日 | 2021-08-04 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | DNA interference states of the hypercompact CRISPR-Cas Phi effector. Nat.Struct.Mol.Biol., 28, 2021
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7LYT
| Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and Phosphorothioate-DNA | 分子名称: | CasPhi, MAGNESIUM ION, NTS-DNA*, ... | 著者 | Pausch, P, Soczek, K, Nogales, E, Doudna, J. | 登録日 | 2021-03-08 | 公開日 | 2021-08-04 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | DNA interference states of the hypercompact CRISPR-Cas Phi effector. Nat.Struct.Mol.Biol., 28, 2021
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8FYA
| Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYB
| Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | 分子名称: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYC
| Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | 分子名称: | Cas1, Cas2-DEDDh, DEDDh, ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FY9
| Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER) | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYD
| Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | 分子名称: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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3H42
| Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody | 分子名称: | Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Piper, D.E, Walker, N.P.C, Romanow, W.G, Thibault, S.T, Tsai, M.M, Yang, E. | 登録日 | 2009-04-17 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc.Natl.Acad.Sci.USA, 106, 2009
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1JY7
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2AAC
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2ARC
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2ARA
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6ORT
| Crystal Structure of Bos taurus Mxra8 Ectodomain | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Matrix remodeling-associated protein 8 | 著者 | Fremont, D.H, Kim, A.S, Nelson, C.A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-04-30 | 公開日 | 2020-03-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. Cell Host Microbe, 27, 2020
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6X2W
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6X2U
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6X2S
| Crystal Structure of Mek1(NQ)NES peptide bound to CRM | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... | 著者 | Baumhardt, J.M. | 登録日 | 2020-05-20 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.496 Å) | 主引用文献 | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6X2M
| Crystal Structure of unliganded CRM1-Ran-RanBP1 | 分子名称: | Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... | 著者 | Baumhardt, J.M. | 登録日 | 2020-05-20 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.351 Å) | 主引用文献 | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6X2P
| Crystal Structure of the Mek1NES peptide bound to CRM1 | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... | 著者 | Baumhardt, J.M. | 登録日 | 2020-05-20 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6X2V
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