4MS8
 
 | | 42F3 TCR pCPB9/H-2Ld Complex | | 分子名称: | 42F3 alpha, 42F3 beta, H-2 class I histocompatibility antigen, ... | | 著者 | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | | 登録日 | 2013-09-18 | | 公開日 | 2014-09-24 | | 最終更新日 | 2018-09-26 | | 実験手法 | X-RAY DIFFRACTION (1.922 Å) | | 主引用文献 | Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
Nat. Immunol., 17, 2016
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4LDE
 | | Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody | | 分子名称: | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ... | | 著者 | Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. | | 登録日 | 2013-06-24 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
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4LDO
 | | Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody | | 分子名称: | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, Camelid Antibody Fragment, L-EPINEPHRINE, ... | | 著者 | Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. | | 登録日 | 2013-06-24 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
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4MQT
 | | Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620 | | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, ... | | 著者 | Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K. | | 登録日 | 2013-09-16 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
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4MXQ
 | | 42F3 TCR pCPC5/H-2Ld Complex | | 分子名称: | 42F3 alpha VmVh chimera, 42F3 beta VmVh chimera, H-2 class I histocompatibility antigen, ... | | 著者 | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | | 登録日 | 2013-09-26 | | 公開日 | 2015-08-19 | | 最終更新日 | 2018-09-26 | | 実験手法 | X-RAY DIFFRACTION (2.596 Å) | | 主引用文献 | Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
Nat. Immunol., 17, 2016
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4MVB
 | | 42F3 pCPB7/H-2Ld Complex | | 分子名称: | 42F3 alpha VmCh, 42F3 beta VmCh, H-2 class I histocompatibility antigen, ... | | 著者 | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | | 登録日 | 2013-09-23 | | 公開日 | 2015-08-19 | | 最終更新日 | 2018-09-26 | | 実験手法 | X-RAY DIFFRACTION (3.088 Å) | | 主引用文献 | Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
Nat. Immunol., 17, 2016
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4N0C
 | | 42F3 TCR pCPE3/H-2Ld complex | | 分子名称: | 42F3 VmCh alpha, 42F3 VmCh beta, H-2 class I histocompatibility antigen, ... | | 著者 | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | | 登録日 | 2013-10-01 | | 公開日 | 2015-08-19 | | 最終更新日 | 2018-09-26 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
Nat. Immunol., 17, 2016
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4N5E
 | | 42F3 TCR pCPA12/H-2Ld complex | | 分子名称: | 42F3 alpha VmCh, 42F3 beta VmCh, H-2 class I histocompatibility antigen, ... | | 著者 | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | | 登録日 | 2013-10-09 | | 公開日 | 2015-08-19 | | 最終更新日 | 2018-09-26 | | 実験手法 | X-RAY DIFFRACTION (3.059 Å) | | 主引用文献 | Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
Nat. Immunol., 17, 2016
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4NHU
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4OFD
 | | Crystal Structure of mouse Neph1 D1-D2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Kin of IRRE-like protein 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Ozkan, E, Garcia, K.C. | | 登録日 | 2014-01-14 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.94 Å) | | 主引用文献 | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
Cell(Cambridge,Mass.), 156, 2014
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6X93
 | | Interleukin-10 signaling complex with IL-10RA and IL-10RB | | 分子名称: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | | 著者 | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | | 登録日 | 2020-06-02 | | 公開日 | 2021-03-17 | | 最終更新日 | 2021-03-31 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Science, 371, 2021
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2IFG
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7RKY
 | | Binding mode of US27-Gi-scFv16 in OCL-state | | 分子名称: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Tsutsumi, N, Jude, K.M, Garcia, K.C. | | 登録日 | 2021-07-22 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKN
 | | Structure of CX3CL1-US28-Gi-scFv16 in OC-state | | 分子名称: | Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... | | 著者 | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | 登録日 | 2021-07-22 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKX
 | | Structure of US27-Gi-scFv16 in CL-state | | 分子名称: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Tsutsumi, N, Jude, K.M, Garcia, K.C. | | 登録日 | 2021-07-22 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKF
 | | Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ... | | 著者 | Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C. | | 登録日 | 2021-07-22 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKM
 | | Structure of CX3CL1-US28-Gi-scFv16 in C-state | | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | | 著者 | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | 登録日 | 2021-07-22 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RAA
 | | Designed StabIL-2 seq15 | | 分子名称: | Interleukin-2, MAGNESIUM ION | | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | | 登録日 | 2021-06-30 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
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4DEP
 | | Structure of the IL-1b signaling complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, Interleukin-1 receptor accessory protein, ... | | 著者 | Thomas, C, Garcia, K.C. | | 登録日 | 2012-01-21 | | 公開日 | 2012-03-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the activating IL-1 receptor signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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2GYZ
 | | Crystal structure of human artemin | | 分子名称: | neurotrophic factor artemin isoform 3 | | 著者 | Wang, X.Q, Garcia, K.C. | | 登録日 | 2006-05-10 | | 公開日 | 2006-06-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
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2H3N
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4F0A
 | | Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-8, PALMITOLEIC ACID, ... | | 著者 | Janda, C.Y, Waghray, D, Levin, A.M, Thomas, C, Garcia, K.C. | | 登録日 | 2012-05-03 | | 公開日 | 2012-06-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structural basis of Wnt recognition by Frizzled.
Science, 337, 2012
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2RKC
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7R86
 | | Structure of mouse BAI1 (ADGRB1) in complex with mouse Nogo receptor (RTN4R) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINOBENZOIC ACID, ... | | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | | 登録日 | 2021-06-26 | | 公開日 | 2021-11-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Cell, 184, 2021
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7R85
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