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Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C)
分子名称:	Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者	VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A.
登録日	2016-06-15
公開日	2016-08-24
最終更新日	2024-03-06
実験手法	ELECTRON MICROSCOPY (6.1 Å)
主引用文献	Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63, 2016

5L9U

Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination
分子名称:	Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者	Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
登録日	2016-06-11
公開日	2016-09-14
最終更新日	2024-05-08
実験手法	ELECTRON MICROSCOPY (6.4 Å)
主引用文献	Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016

5L9T

Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density
分子名称:	Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者	Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
登録日	2016-06-11
公開日	2016-10-26
最終更新日	2024-05-08
実験手法	ELECTRON MICROSCOPY (6.4 Å)
主引用文献	Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016

5M0Y

Crystal Structure of the CohScaA-XDocCipB type II complex from Clostridium thermocellum at 1.5Angstrom resolution
分子名称:	1,2-ETHANEDIOL, CALCIUM ION, Cellulosome anchoring protein cohesin region, ...
著者	Pinheiro, B.A, Bras, J.L, Carvalho, A.L, Fontes, C.M.G.A.
登録日	2016-10-06
公開日	2017-09-06
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Diverse specificity of cellulosome attachment to the bacterial cell surface. Sci Rep, 6, 2016

7Z8B

Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
分子名称:	Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ...
著者	Hopf, L.V.M, Schulman, B.A.
登録日	2022-03-17
公開日	2022-08-24
最終更新日	2022-10-05
実験手法	ELECTRON MICROSCOPY (2.8 Å)
主引用文献	Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. Nat.Struct.Mol.Biol., 29, 2022

7Z8T

CAND1-SCF-SKP2 CAND1 engaged SCF rocked
分子名称:	Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者	Baek, K, Schulman, B.A.
登録日	2022-03-18
公開日	2023-04-19
最終更新日	2023-05-10
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023

7ZBW

CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged
分子名称:	Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者	Baek, K, Schulman, B.A.
登録日	2022-03-24
公開日	2023-04-19
最終更新日	2023-05-10
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023

7Z8R

CAND1-CUL1-RBX1
分子名称:	Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者	Baek, K, Schulman, B.A.
登録日	2022-03-18
公開日	2023-04-19
最終更新日	2023-05-10
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023

7Z8V

CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked
分子名称:	Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者	Baek, K, Schulman, B.A.
登録日	2022-03-18
公開日	2023-04-19
最終更新日	2023-05-10
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023

7ZBZ

CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked
分子名称:	Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者	Baek, K, Schulman, B.A.
登録日	2022-03-24
公開日	2023-04-19
最終更新日	2023-05-10
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023

7ZMU

14-3-3s binding to non-natural peptide 2d
分子名称:	14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 2
著者	Somsen, B.A, Craenmehr, F.W.B, Ottmann, C.
登録日	2022-04-19
公開日	2022-11-23
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022

7ZMW

14-3-3s binding to non-natural peptide 2c
分子名称:	14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 1
著者	Somsen, B.A, Craenmehr, F.W.B, Ottmann, C.
登録日	2022-04-19
公開日	2022-11-23
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022

7ZVO

Structure of CBM BT0996-C from Bacteroides thetaiotaomicron
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, ALANINE, BETA-MERCAPTOETHANOL, ...
著者	Trovao, F, Pinheiro, B.A, Correia, V.G, Palma, A.S, Carvalho, A.L.
登録日	2022-05-16
公開日	2023-02-08
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	The structure of a Bacteroides thetaiotaomicron carbohydrate-binding module provides new insight into the recognition of complex pectic polysaccharides by the human microbiome. J Struct Biol X, 7, 2023

8B2K

Ternary structure of 14-3-3s, RND3 phosphopeptide and dual-reactive compound 10
分子名称:	14-3-3 protein sigma, 3-bromanyl-5-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-09-14
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8B2I

Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 4
分子名称:	14-3-3 protein sigma, 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-09-14
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8B4Q

Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 5
分子名称:	14-3-3 protein sigma, 3-fluoranyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-09-20
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8B5P

Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 10
分子名称:	14-3-3 protein sigma, 3-bromanyl-5-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-09-23
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8BM5

Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 7
分子名称:	14-3-3 protein sigma, 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzenesulfonamide, CHLORIDE ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-11-10
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8BJN

Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 6
分子名称:	14-3-3 protein sigma, 3-bromanyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-11-04
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8BFC

Binary structure of 14-3-3s and RND3 phosphopeptide
分子名称:	14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-10-24
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8BI7

Binary structure of 14-3-3s and PKR phosphopeptide
分子名称:	14-3-3 protein sigma, MAGNESIUM ION, PKR phosphopeptide
著者	Somsen, B.A, Ottmann, C.
登録日	2022-11-01
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8BJG

Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8
分子名称:	14-3-3 protein sigma, 3-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者	Somsen, B.A, Ottmann, C.
登録日	2022-11-04
公開日	2023-03-29
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

8C07

Structure of HECT E3 UBR5 forming K48 linked Ubiquitin chains
分子名称:	5-azanylpentan-2-one, E3 ubiquitin-protein ligase UBR5, Polyubiquitin-B
著者	Hehl, L.A, Prabu, J.R, Schulman, B.A.
登録日	2022-12-16
公開日	2023-08-23
最終更新日	2024-02-14
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. Nat.Chem.Biol., 20, 2024

8C06

Structure of Dimeric HECT E3 Ubiquitin Ligase UBR5
分子名称:	E3 ubiquitin-protein ligase UBR5, ZINC ION
著者	Hehl, L.A, Prabu, J.R, Schulman, B.A.
登録日	2022-12-16
公開日	2023-08-23
最終更新日	2024-02-14
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. Nat.Chem.Biol., 20, 2024

8BD0

Human Gamma-D crystallin R36S mutant with DTT-Cystein Protein modification
分子名称:	2,3-DIHYDROXY-1,4-DITHIOBUTANE, Human Gamma-D Crystallin R36S
著者	Yorke, B.A, Hill, J.A.
登録日	2022-10-17
公開日	2023-11-01
最終更新日	2024-05-15
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin. Commun Chem, 7, 2024

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全ヒット件数:	2747
表示件数:	25
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