7CJA
 
 | | Crystal structure of TTK kinase domain in complex with compound 28 | | 分子名称: | 4-(cyclopentylmethylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | | 登録日 | 2020-07-09 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
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7CIL
 | | Crystal structure of TTK kinase domain in complex with compound 7 | | 分子名称: | 4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
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5C16
 | | Myotubularin-related proetin 1 | | 分子名称: | Myotubularin-related protein 1, PHOSPHATE ION | | 著者 | Lee, B.I, Bong, S.M. | | 登録日 | 2015-06-13 | | 公開日 | 2016-04-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity
Plos One, 11, 2016
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5ZHF
 | | Structure of VanYB unbound | | 分子名称: | D-alanyl-D-alanine carboxypeptidase, GLYCEROL, TETRAETHYLENE GLYCOL, ... | | 著者 | Kim, H.S, Hahn, H. | | 登録日 | 2018-03-13 | | 公開日 | 2018-09-05 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanYB.
Int. J. Biol. Macromol., 119, 2018
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5ZHW
 | | VanYB in complex with D-Alanine-D-Alanine | | 分子名称: | COPPER (II) ION, D-ALANINE, D-alanyl-D-alanine carboxypeptidase, ... | | 著者 | Kim, H.S, Hahn, H. | | 登録日 | 2018-03-13 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanYB.
Int. J. Biol. Macromol., 119, 2018
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6USY
 | | COAGULATION FACTOR XI CATALYTIC DOMAIN (C123S) IN COMPLEX WITH NVP-XIV936 | | 分子名称: | 1-[(2S)-2-{3-[(3S)-3-amino-2,3-dihydro-1-benzofuran-5-yl]-5-(propan-2-yl)phenyl}-2-hydroxyethyl]-1H-indole-7-carboxylic acid, Coagulation factor XIa light chain | | 著者 | Weihofen, W.A, Clark, K, Nunes, S. | | 登録日 | 2019-10-28 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | | 主引用文献 | Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J.Med.Chem., 63, 2020
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5XTG
 | | Crystal structure of the cis-dihydrodiol naphthalene dehydrogenase NahB from Pseudomonas sp. MC1 in the presence of NAD+ and 2,3-dihydroxybiphenyl | | 分子名称: | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, BIPHENYL-2,3-DIOL, CITRIC ACID, ... | | 著者 | Park, A.K, Kim, H.-W. | | 登録日 | 2017-06-19 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.318 Å) | | 主引用文献 | Crystal structure of cis-dihydrodiol naphthalene dehydrogenase (NahB) from Pseudomonas sp. MC1: Insights into the early binding process of the substrate
Biochem. Biophys. Res. Commun., 491, 2017
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5XTF
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5ZRD
 | | Tyrosinase from Burkholderia thailandensis (BtTYR) at low pH condition | | 分子名称: | CITRIC ACID, COPPER (II) ION, GLYCEROL, ... | | 著者 | Lee, S, Son, H.-F, Kim, K.-J. | | 登録日 | 2018-04-24 | | 公開日 | 2018-10-31 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for Highly Efficient Production of Catechol Derivatives at Acidic pH by Tyrosinase from Burkholderia thailandensis
Acs Catalysis, 8, 2018
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5ZRE
 | | Tyrosinase from Burkholderia thailandensis (BtTYR) at high pH condition | | 分子名称: | COPPER (II) ION, GLYCEROL, OXYGEN ATOM, ... | | 著者 | Lee, S, Son, H.-F, Kim, K.-J. | | 登録日 | 2018-04-24 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Basis for Highly Efficient Production of Catechol Derivatives at Acidic pH by Tyrosinase from Burkholderia thailandensis
Acs Catalysis, 8, 2018
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2G96
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2G95
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6IWD
 | | The PTP domain of human PTPN14 in a complex with the CR3 domain of HPV18 E7 | | 分子名称: | CHLORIDE ION, HPV18 E7, PHOSPHATE ION, ... | | 著者 | Yun, H.-Y, Kim, S.J, Ku, B. | | 登録日 | 2018-12-05 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus.
Plos Biol., 17, 2019
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6TL8
 | | Structural basis of SALM3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Myeloid cell surface antigen CD33,Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | | 著者 | Karki, S, Shkumatov, A.V, Bae, S, Ko, J, Kajander, T. | | 登録日 | 2019-12-02 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTP sigma.
Sci Rep, 10, 2020
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5YSS
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3P2F
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3P2H
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7DIB
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7LFO
 | | Protein Tyrosine Phosphatase 1B | | 分子名称: | MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Sarkar, A, Kim, E.Y, Hongdusit, A, Sankaran, B, Fox, J.M. | | 登録日 | 2021-01-18 | | 公開日 | 2021-05-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products.
Acs Synth Biol, 10, 2021
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5ZXB
 | | Crystal structure of ACK1 with compound 10d | | 分子名称: | Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | | 著者 | Hong, E.M, Kim, H.L, Sim, T.B. | | 登録日 | 2018-05-18 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.
J. Med. Chem., 61, 2018
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7EC1
 | | Crystal structure of SdgB (ligand-free form) | | 分子名称: | GLYCEROL, Glycosyl transferase, group 1 family protein, ... | | 著者 | Kim, D.-G, Baek, I, Lee, Y, Kim, H.S. | | 登録日 | 2021-03-11 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol, 77, 2021
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3WUT
 | | Structure basis of inactivating cell abscission | | 分子名称: | Centrosomal protein of 55 kDa, GLYCEROL, Inactive serine/threonine-protein kinase TEX14 | | 著者 | Kim, H.J, Matsuura, A, Lee, H.H. | | 登録日 | 2014-05-05 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells.
Proc.Natl.Acad.Sci.USA, 112, 2015
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3WUV
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7EC3
 | | Crystal structure of SdgB (complexed with UDP, GlcNAc, and Glycosylated peptide) | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-35)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-65)]5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycosyl transferase, ... | | 著者 | Kim, D.-G, Baek, I, Lee, Y, Kim, H.S. | | 登録日 | 2021-03-11 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol, 77, 2021
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7EC7
 | | Crystal structure of SdgB (complexed with phosphate ions) | | 分子名称: | Glycosyl transferase, group 1 family protein, PHOSPHATE ION | | 著者 | Kim, D.-G, Baek, I, Lee, Y, Kim, H.S. | | 登録日 | 2021-03-11 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol, 77, 2021
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