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8HO6
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ScRIPK WT
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ScRIPK kinase protein
著者Fang, J.L, Zhang, M.Q.
登録日2022-12-09
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis.
Front Plant Sci, 14, 2023
8I2C
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E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface
分子名称: 1,2-ETHANEDIOL, 4-methoxyaniline, SULFATE ION, ...
著者Xiang, M, Zhou, H.
登録日2023-01-14
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I2M
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The crystal structure of homodimeric E. coli tryptophanyl-tRNA synthetase bound with niraparib at one of its two active sites
分子名称: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide, SULFATE ION, TRYPTOPHANYL-5'AMP, ...
著者Xiang, M, Zhou, H.
登録日2023-01-14
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I1Z
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E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment
分子名称: 1-(2,3-dihydro-1-benzofuran-5-yl)ethanone, SULFATE ION, TRYPTOPHANYL-5'AMP, ...
著者Xiang, M, Zhou, H.
登録日2023-01-13
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I27
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E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface
分子名称: 1,2-ETHANEDIOL, 4-methoxybenzenecarbonitrile, SULFATE ION, ...
著者Xiang, M, Zhou, H.
登録日2023-01-14
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I2A
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BU of 8i2a by Molmil
E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface
分子名称: 1,2-ETHANEDIOL, 5-METHOXYBENZIMIDAZOLE, SULFATE ION, ...
著者Xiang, M, Zhou, H.
登録日2023-01-14
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I4I
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BU of 8i4i by Molmil
The asymmetric structure of homodimeric E. coli TrpRS bound with tryptophanyl adenylate and L-tryptophan
分子名称: SULFATE ION, TRYPTOPHAN, TRYPTOPHANYL-5'AMP, ...
著者Xiang, M, Zhou, H.
登録日2023-01-19
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I2J
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BU of 8i2j by Molmil
E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface
分子名称: 1-(4-methoxyphenyl)ethanone, SULFATE ION, TRYPTOPHANYL-5'AMP, ...
著者Xiang, M, Zhou, H.
登録日2023-01-14
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I1W
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The asymmetric structure of homodimeric E. coli TrpRS bound with tryptophanyl adenylate at one of its two active pockets
分子名称: SULFATE ION, TRYPTOPHANYL-5'AMP, Tryptophan--tRNA ligase
著者Xiang, M, Zhou, H.
登録日2023-01-13
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I1Y
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BU of 8i1y by Molmil
The structure of E. coli TrpRS bound with a chemical fragment
分子名称: 5-ethanoylthiophene-2-carbonitrile, SULFATE ION, TRYPTOPHANYL-5'AMP, ...
著者Xiang, M, Zhou, H.
登録日2023-01-13
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
8I2L
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BU of 8i2l by Molmil
E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface
分子名称: 1,2-ETHANEDIOL, CHLORZOXAZONE, SULFATE ION, ...
著者Xiang, M, Zhou, H.
登録日2023-01-14
公開日2023-04-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Nucleic Acids Res., 51, 2023
7TZL
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The DH dehydratase domain of AlnB
分子名称: 3-oxoacyl-[acyl-carrier-protein] reductase
著者Swain, K, Blackson, W, Wang, B, Zhao, H, Nannenga, B.L.
登録日2022-02-16
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The programming of alpha,beta-polyene biosynthesis by a bacterial iterative type I polyketide synthase
To Be Published
3FUS
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BU of 3fus by Molmil
Improved Structure of the Unliganded Simian Immunodeficiency Virus gp120 Core
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, X, Poon, B, Wang, Q, Ma, J.
登録日2009-01-14
公開日2009-06-30
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinement.
Acta Crystallogr.,Sect.D, 65, 2009
7TXW
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BU of 7txw by Molmil
Crystal structure of the complex of the malaria sexual stage protein and vaccine target Pfs25 with the Fab fragment of a transmission blocking antibody 1G2
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ETHANOL, ...
著者Singh, K, Gittis, A.G, Garboczi, D.N.
登録日2022-02-10
公開日2023-04-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles.
Npj Vaccines, 8, 2023
6ORE
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BU of 6ore by Molmil
Release complex 70S
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Fu, Z.
登録日2019-04-30
公開日2019-06-19
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy.
Nat Commun, 10, 2019
7UNN
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BU of 7unn by Molmil
Thiol-disulfide oxidoreductase TsdA from Corynebacterium diphtheriae
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Thioredoxin domain-containing protein
著者Osipiuk, J, Reardon-Robinson, M, Nguyen, M.T, Sanchez, B, Ton-That, H, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2022-04-11
公開日2022-04-20
最終更新日2023-05-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A cryptic oxidoreductase safeguards oxidative protein folding in Corynebacterium diphtheriae.
Proc.Natl.Acad.Sci.USA, 120, 2023
7N64
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SARS-CoV-2 Spike (2P) in complex with G32R7 Fab (RBD and NTD local reconstruction)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, G32R7 Fab heavy chain, ...
著者Windsor, I.W, Jenni, S, Tong, P, Gautam, A.K, Wesemann, D.R, Harrison, S.C.
登録日2021-06-07
公開日2021-08-04
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Biorxiv, 2021
7N62
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BU of 7n62 by Molmil
SARS-CoV-2 Spike (2P) in complex with C12C9 Fab (NTD local reconstruction)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C12C9 Fab heavy chain, C12C9 Fab light chain, ...
著者Windsor, I.W, Jenni, S, Bajic, G, Tong, P, Gautam, A.K, Wesemann, D.R, Harrison, S.C.
登録日2021-06-07
公開日2021-08-04
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Biorxiv, 2021
4RUL
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BU of 4rul by Molmil
Crystal structure of full-length E.Coli topoisomerase I in complex with ssDNA
分子名称: DNA topoisomerase 1, GLYCEROL, SULFATE ION, ...
著者Tan, K, Chen, B, Tse-Dinh, Y.C.
登録日2014-11-20
公開日2015-11-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I.
Nucleic Acids Res., 43, 2015
3BEN
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BU of 3ben by Molmil
Structure of N-(12-imidazolyl-dodecanoyl)-L-leucine inhibitor bound to the heme domain of Cytochrome P450-BM3
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cytochrome P450 102, MAGNESIUM ION, ...
著者Tomchick, D.R.
登録日2007-11-19
公開日2008-09-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.
Biochemistry, 47, 2008
5VFD
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BU of 5vfd by Molmil
Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii
分子名称: (2S,5R)-1-formyl-4-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, (2S,5R)-4-methyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-3-ene-2-carboxamide, Beta-lactamase, ...
著者Olivier, N.B, Lahiri, S.
登録日2017-04-07
公開日2017-06-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献ETX2514 is a broad-spectrum beta-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.
Nat Microbiol, 2, 2017
5TOU
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BU of 5tou by Molmil
STRUCTURE OF C-PHYCOCYANIN FROM ARCTIC PSEUDANABAENA SP. LW0831
分子名称: PHYCOCYANOBILIN, Phycocyanin alpha-1 subunit, Phycocyanin beta-1 subunit
著者Wang, Q.M, Li, C.Y, Su, H.N, Zhang, Y.Z, Xie, B.B.
登録日2016-10-18
公開日2017-03-08
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structural insights into the cold adaptation of the photosynthetic pigment-protein C-phycocyanin from an Arctic cyanobacterium
Biochim. Biophys. Acta, 1858, 2017
7XH8
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BU of 7xh8 by Molmil
The structure of ZCB11 Fab against SARS-CoV-2 Omicron Spike
分子名称: Spike glycoprotein, The heavy chain of ZCB11 antibody, The light chain of ZCB11 antibody
著者Hang, L, Dang, S.
登録日2022-04-07
公開日2022-06-29
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge.
Nat Commun, 13, 2022
7YKJ
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Omicron RBDs bound with P3E6 Fab (one up and one down)
分子名称: P3E6 heavy chain, P3E6 light chain, Spike glycoprotein
著者Tang, B, Dang, S.
登録日2022-07-22
公開日2022-12-28
最終更新日2023-01-18
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.
Emerg Microbes Infect, 12, 2023
5FEQ
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EGFR KINASE DOMAIN IN COMPLEX WITH A COVALENT AMINOBENZIMIDAZOLE
分子名称: Epidermal growth factor receptor, ~{N}-[1-[(3~{R})-1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-benzimidazol-2-yl]-2-methyl-pyridine-4-carboxamide
著者DiDonato, M, Spraggon, G.
登録日2015-12-17
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
J.Med.Chem., 59, 2016

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件を2024-06-12に公開中

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