5VFD
Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii
Summary for 5VFD
Entry DOI | 10.2210/pdb5vfd/pdb |
Descriptor | Beta-lactamase, SULFATE ION, (2S,5R)-1-formyl-4-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, ... (5 entities in total) |
Functional Keywords | etx2514, beta-lactamase, pbp gram negative, astrazeneca, entasis, a. baumannii, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Acinetobacter baumannii |
Total number of polymer chains | 1 |
Total formula weight | 28623.50 |
Authors | Olivier, N.B.,Lahiri, S. (deposition date: 2017-04-07, release date: 2017-06-07, Last modification date: 2023-11-15) |
Primary citation | Durand-Reville, T.F.,Guler, S.,Comita-Prevoir, J.,Chen, B.,Bifulco, N.,Huynh, H.,Lahiri, S.,Shapiro, A.B.,McLeod, S.M.,Carter, N.M.,Moussa, S.H.,Velez-Vega, C.,Olivier, N.B.,McLaughlin, R.,Gao, N.,Thresher, J.,Palmer, T.,Andrews, B.,Giacobbe, R.A.,Newman, J.V.,Ehmann, D.E.,de Jonge, B.,O'Donnell, J.,Mueller, J.P.,Tommasi, R.A.,Miller, A.A. ETX2514 is a broad-spectrum beta-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nat Microbiol, 2:17104-17104, 2017 Cited by PubMed: 28665414DOI: 10.1038/nmicrobiol.2017.104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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