5VFD

Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii

Summary for 5VFD

• Entry DOI: 10.2210/pdb5vfd/pdb
• Descriptor: Beta-lactamase, SULFATE ION, (2S,5R)-1-formyl-4-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, ... (5 entities in total)
• Functional Keywords: etx2514, beta-lactamase, pbp gram negative, astrazeneca, entasis, a. baumannii, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 1
• Total formula weight: 28623.50

Authors

Olivier, N.B.,Lahiri, S. (deposition date: 2017-04-07, release date: 2017-06-07, Last modification date: 2023-11-15)

• Primary citation: Durand-Reville, T.F.,Guler, S.,Comita-Prevoir, J.,Chen, B.,Bifulco, N.,Huynh, H.,Lahiri, S.,Shapiro, A.B.,McLeod, S.M.,Carter, N.M.,Moussa, S.H.,Velez-Vega, C.,Olivier, N.B.,McLaughlin, R.,Gao, N.,Thresher, J.,Palmer, T.,Andrews, B.,Giacobbe, R.A.,Newman, J.V.,Ehmann, D.E.,de Jonge, B.,O'Donnell, J.,Mueller, J.P.,Tommasi, R.A.,Miller, A.A.; ETX2514 is a broad-spectrum beta-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.; Nat Microbiol, 2:17104-17104, 2017; PubMed: 28665414; DOI: 10.1038/nmicrobiol.2017.104

Experimental method

X-RAY DIFFRACTION (1.93 Å)