7TXW
Crystal structure of the complex of the malaria sexual stage protein and vaccine target Pfs25 with the Fab fragment of a transmission blocking antibody 1G2
Summary for 7TXW
Entry DOI | 10.2210/pdb7txw/pdb |
Descriptor | Fab fragment of monoclonal antibody 1G2 light chain, Fab fragment of monoclonal antibody 1G2 heavy chain, Ookinete surface protein P25, ... (8 entities in total) |
Functional Keywords | malaria, transmission blocking vaccine, immune system |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 67596.14 |
Authors | Singh, K.,Gittis, A.G.,Garboczi, D.N. (deposition date: 2022-02-10, release date: 2023-04-12, Last modification date: 2024-04-03) |
Primary citation | MacDonald, N.J.,Singh, K.,Reiter, K.,Nguyen, V.,Shimp Jr., R.,Gittis, A.G.,Chen, B.,Burkhardt, M.,Zhang, B.,Wang, Z.,Herrera, R.,Moler, M.,Lee, D.Y.,Orr-Gonzalez, S.,Herrod, J.,Lambert, L.E.,Rausch, K.M.,Muratova, O.,Jones, D.S.,Wu, Y.,Jin, A.J.,Garboczi, D.N.,Duffy, P.E.,Narum, D.L. Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles. Npj Vaccines, 8:56-56, 2023 Cited by PubMed: 37061547DOI: 10.1038/s41541-023-00655-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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