7TXW

Crystal structure of the complex of the malaria sexual stage protein and vaccine target Pfs25 with the Fab fragment of a transmission blocking antibody 1G2

Summary for 7TXW

Entry DOI	10.2210/pdb7txw/pdb
Descriptor	Fab fragment of monoclonal antibody 1G2 light chain, Fab fragment of monoclonal antibody 1G2 heavy chain, Ookinete surface protein P25, ... (8 entities in total)
Functional Keywords	malaria, transmission blocking vaccine, immune system
Biological source	Mus musculus (mouse) More
Total number of polymer chains	3
Total formula weight	67596.14
Authors	Singh, K.,Gittis, A.G.,Garboczi, D.N. (deposition date: 2022-02-10, release date: 2023-04-12, Last modification date: 2024-04-03)
Primary citation	MacDonald, N.J.,Singh, K.,Reiter, K.,Nguyen, V.,Shimp Jr., R.,Gittis, A.G.,Chen, B.,Burkhardt, M.,Zhang, B.,Wang, Z.,Herrera, R.,Moler, M.,Lee, D.Y.,Orr-Gonzalez, S.,Herrod, J.,Lambert, L.E.,Rausch, K.M.,Muratova, O.,Jones, D.S.,Wu, Y.,Jin, A.J.,Garboczi, D.N.,Duffy, P.E.,Narum, D.L. Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles. Npj Vaccines, 8:56-56, 2023 Cited by PubMed: 37061547 DOI: 10.1038/s41541-023-00655-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation