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2I59
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Solution structure of RGS10
分子名称: Regulator of G-protein signaling 10
著者Fedorov, O, Higman, V.A, Diehl, A, Leidert, M, Lemak, A, Schmieder, P, Oschkinat, H, Elkins, J, Soundarajan, M, Doyle, D.A, Arrowsmith, C, Sundstrom, M, Weigelt, J, Edwards, A, Ball, L.J, Structural Genomics Consortium (SGC)
登録日2006-08-24
公開日2006-10-31
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ID3
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Crystal structure of transcriptional regulator SCO5951 from Streptomyces coelicolor A3(2)
分子名称: CALCIUM ION, CHLORIDE ION, Putative transcriptional regulator
著者Grabowski, M, Chruszcz, M, Koclega, K.D, Cymborowski, M, Gu, J, Xu, X, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
登録日2006-09-14
公開日2006-10-17
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献

2J8Q
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Crystal structure of human cleavage and polyadenylation specificity factor 5 (CPSF5) in complex with a sulphate ion.
分子名称: CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 5, SULFATE ION
著者Moche, M, Stenmark, P, Ogg, D, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg, S.L, Hogbom, M, Johansson, I, Karlberg, T, Kosinska, U, Kotenyova, T, Magnusdottir, A, Nilsson, M.E, Nilsson-Ehle, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Upsten, M, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Welin, M, Nordlund, P.
登録日2006-10-27
公開日2006-11-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Crystal Structure of Human Cleavage and Polyadenylation Specific Factor-5 Reveals a Dimeric Nudix Protein with a Conserved Catalytic Site.
Proteins, 73, 2008
2IWO
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12th PDZ domain of Multiple PDZ Domain Protein MPDZ
分子名称: MULTIPLE PDZ DOMAIN PROTEIN
著者Elkins, J.M, Yang, X, Gileadi, C, Schoch, G, Johansson, C, Savitsky, P, Berridge, G, Smee, C.E.A, Turnbull, A, Pike, A, Papagrigoriou, E, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Doyle, D.A.
登録日2006-07-03
公開日2006-07-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2IWP
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12th PDZ domain of Multiple PDZ Domain Protein MPDZ
分子名称: MULTIPLE PDZ DOMAIN PROTEIN
著者Elkins, J.M, Yang, X, Gileadi, C, Schoch, G, Johansson, C, Savitsky, P, Berridge, G, Smee, C.E.A, Turnbull, A, Pike, A, Papagrigoriou, E, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Doyle, D.A.
登録日2006-07-03
公開日2006-07-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2J4E
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THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE
分子名称: INOSINE 5'-TRIPHOSPHATE, INOSINE TRIPHOSPHATE PYROPHOSPHATASE, INOSINIC ACID, ...
著者Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmbergschiavone, L, Hogbom, M, Kotenyova, T, Landry, R, Loppnau, P, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Schuler, H, Van Den Berg, S, Wallden, K, Weigelt, J, Nordlund, P.
登録日2006-08-29
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.
J.Biol.Chem., 282, 2007
2JGA
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Crystal structure of human cytosolic 5'-nucleotidase III in complex with phosphate and magnesium
分子名称: CYTOSOLIC 5'-NUCLEOTIDASE III, MAGNESIUM ION, PHOSPHATE ION
著者Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, M, Holmberg, B, Schiavone, L, Hogbom, M, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Thorsell, A.G, Uppenberg, J, Van Den Berg, S, Weigelt, J, Welin, M, Nordlund, P.
登録日2007-02-09
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition.
J.Biol.Chem., 282, 2007
2JCM
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Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with beryllium trifluoride
分子名称: CYTOSOLIC PURINE 5'-NUCLEOTIDASE, MAGNESIUM ION, SULFATE ION, ...
著者Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P.
登録日2006-12-27
公開日2007-01-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2KFV
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Structure of the amino-terminal domain of human FK506-binding protein 3 / Northeast Structural Genomics Consortium Target HT99A
分子名称: FK506-binding protein 3
著者Sunnerhagen, M, Davis, T, Gutmanas, A, Fares, C, Ouyang, H, Lemak, A, Li, Y, Weigelt, J, Bountra, C, Edwards, A, Arrowsmith, C.H, Dhe-Paganon, S, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
登録日2009-02-27
公開日2009-06-23
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Structure of the N-terminal domain of FK506-binding protein 3
To be Published
2HW4
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Crystal structure of human phosphohistidine phosphatase
分子名称: 14 kDa phosphohistidine phosphatase, FORMIC ACID
著者Busam, R.D, Thorsell, A.G, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Holmberg Schiavone, L, Hogbom, M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Ogg, D, Stenmark, P, Sundstrom, M, Uppenberg, J, Van Den Berg, S, Weigelt, J, Persson, C, Hallberg, B.M, Structural Genomics Consortium (SGC)
登録日2006-07-31
公開日2006-08-29
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献First structure of a eukaryotic phosphohistidine phosphatase
J.Biol.Chem., 281, 2006
2GSE
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Crystal Structure of Human Dihydropyrimidinease-like 2
分子名称: CALCIUM ION, Dihydropyrimidinase-related protein 2
著者Ogg, D, Stenmark, P, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Kotenyova, T, Kursula, P, Nilsson-Ehle, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Holmberg-Schiavone, L, Thorsell, A.G, Uppenberg, J, Van Den Berg, S, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2006-04-26
公開日2006-05-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The structure of human collapsin response mediator protein 2, a regulator of axonal growth.
J.Neurochem., 101, 2007
2I75
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Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4)
分子名称: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 4
著者Ugochukwu, E, Barr, A, Savitsky, P, Burgess, N, Das, S, Turnbull, A, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC)
登録日2006-08-30
公開日2006-10-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2HE7
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FERM domain of EPB41L3 (DAL-1)
分子名称: Band 4.1-like protein 3
著者Hallberg, B.M, Busam, R.D, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Schiavone, L.H, Johansson, I, Hogbom, M, Karlberg, T, Kotenyova, T, Nilvebrandt, J, Norberg, P, Stenmark, P, Nordlund, P, Nilsson-ehle, P, Nyman, T, Ogg, D, Sagemark, J, Sundstrom, M, Uppenberg, J, Van den berg, S, Weigelt, J, Persson, C, Thorsell, A.G, Structural Genomics Consortium (SGC)
登録日2006-06-21
公開日2006-07-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).
J.Biol.Chem., 286, 2011
2GJT
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Crystal structure of the human receptor phosphatase PTPRO
分子名称: CHLORIDE ION, Receptor-type tyrosine-protein phosphatase PTPRO
著者Barr, A, Ugochukwu, E, Eswaran, J, Das, S, Niesen, F, Savitsky, P, Turnbull, A, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, von Delft, F, Papagrigoriou, E, Knapp, S, Structural Genomics Consortium (SGC)
登録日2006-03-31
公開日2006-05-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2QC8
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Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Glutamine synthetase, ...
著者Karlberg, T, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hogbom, M, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2007-06-19
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375, 2008
2JRZ
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Solution structure of the Bright/ARID domain from the human JARID1C protein.
分子名称: Histone demethylase JARID1C
著者Koehler, C, Bishop, S, Dowler, E.F, Diehl, A, Schmieder, P, Leidert, M, Sundstrom, M, Arrowsmith, C.H, Wiegelt, J, Edwards, A, Oschkinat, H, Ball, L.J, Structural Genomics Consortium (SGC)
登録日2007-06-29
公開日2007-07-10
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein.
Biomol.Nmr Assign., 2, 2008
2JC9
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Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine
分子名称: ADENOSINE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ...
著者Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg, S.L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P.
登録日2006-12-21
公開日2007-01-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2J6L
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Structure of aminoadipate-semialdehyde dehydrogenase
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ALDEHYDE DEHYDROGENASE FAMILY 7 MEMBER A1, BROMIDE ION, ...
著者Bunkoczi, G, Guo, K, Debreczeni, J.E, Smee, C, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, von Delft, F, Oppermann, U.
登録日2006-09-29
公開日2006-10-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Aldehyde Dehydrogenase 7A1 (Aldh7A1) is a Novel Enzyme Involved in Cellular Defense Against Hyperosmotic Stress.
J.Biol.Chem., 285, 2010
2J51
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Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide
分子名称: 1,2-ETHANEDIOL, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, ...
著者Pike, A.C.W, Rellos, P, Fedorov, O, Keates, T, Salah, E, Savitsky, P, Papagrigoriou, E, Turnbull, A.P, Debreczeni, J.E, von Delft, F, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S.
登録日2006-09-08
公開日2006-10-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2JFM
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CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)
分子名称: 1,2-ETHANEDIOL, STE20-LIKE SERINE-THREONINE KINASE
著者Pike, A.C.W, Rellos, P, Fedorov, O, Keates, T, Salah, E, Savitsky, P, Papagrigoriou, E, Bunkoczi, G, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S.
登録日2007-02-02
公開日2007-02-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2J90
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Crystal structure of human ZIP kinase in complex with a tetracyclic pyridone inhibitor (Pyridone 6)
分子名称: 1,2-ETHANEDIOL, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, CHLORIDE ION, ...
著者Turnbull, A.P, Berridge, G, Fedorov, O, Pike, A.C.W, Savitsky, P, Eswaran, J, Papagrigoriou, E, Ugochukwa, E, von Delft, F, Gileadi, O, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S.
登録日2006-10-31
公開日2006-11-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2BZN
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Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP
分子名称: GMP REDUCTASE 2, INOSINIC ACID
著者Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Graslund, S, Hammarstrom, M, Hallberg, B.M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A, Weigelt, J.
登録日2005-08-19
公開日2005-09-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes.
Nat.Chem.Biol., 7, 2011
2J7T
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Crystal structure of human serine threonine kinase-10 bound to SU11274
分子名称: (3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-1H-PYRROL-2-YL}METHYLENE)-N-METHYL-2-OXOINDOLINE-5-SULFONAMIDE, ACETATE ION, CALCIUM ION, ...
著者Pike, A.C.W, Rellos, P, Fedorov, O, Das, S, Debreczeni, J, Sobott, F, Watt, S, Savitsky, P, Eswaran, J, Turnbull, A.P, Papagrigoriou, E, Ugochukwa, E, Gorrec, F, Umeano, C.C, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S.
登録日2006-10-17
公開日2006-11-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2BZL
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION
分子名称: 1,2-ETHANEDIOL, SULFATE ION, TYROSINE-PROTEIN PHOSPHATASE, ...
著者Debreczeni, J.E, Barr, A, Eswaran, J, Das, S, Burgess, N, Longman, E, Fedorov, O, Gileadi, O, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Knapp, S.
登録日2005-08-18
公開日2005-09-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal Structure of Human Protein Tyrosine Phosphatase 14 (Ptpn14) at 1.65-A Resolution.
Proteins, 63, 2006
2BV1
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Regulator of G-protein Signalling 1 (Human)
分子名称: REGULATOR OF G-PROTEIN SIGNALLING 1
著者Elkins, J.M, Yang, X, Soundararajan, M, Schoch, G.A, Haroniti, A, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A.
登録日2005-06-20
公開日2005-06-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc. Natl. Acad. Sci. U.S.A., 105, 2008

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