Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

Summary for 2QC8

DescriptorGlutamine synthetase, MANGANESE (II) ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsamino-acid biosynthesis, ligase, synthetase, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15104
Total number of polymer chains10
Total molecular weight442524.46
Primary citation
Krajewski, W.W.,Collins, R.,Holmberg-Schiavone, L.,Jones, T.A.,Karlberg, T.,Mowbray, S.L.
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375:217-228, 2008
PubMed: 18005987 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2007.10.029
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22130.1%2.0%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2qc8
no rotation
Molmil generated image of 2qc8
rotated about x axis by 90°
Molmil generated image of 2qc8
rotated about y axis by 90°
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