Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2QC8

Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001525	biological_process	angiogenesis
A	0003824	molecular_function	catalytic activity
A	0004356	molecular_function	glutamine synthetase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006538	biological_process	L-glutamate catabolic process
A	0006542	biological_process	glutamine biosynthetic process
A	0008283	biological_process	cell population proliferation
A	0010594	biological_process	regulation of endothelial cell migration
A	0016740	molecular_function	transferase activity
A	0016874	molecular_function	ligase activity
A	0018345	biological_process	protein palmitoylation
A	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
A	0042254	biological_process	ribosome biogenesis
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0097275	biological_process	intracellular ammonium homeostasis
A	0097386	cellular_component	glial cell projection
A	1903670	biological_process	regulation of sprouting angiogenesis
A	1904749	biological_process	regulation of protein localization to nucleolus
B	0000166	molecular_function	nucleotide binding
B	0001525	biological_process	angiogenesis
B	0003824	molecular_function	catalytic activity
B	0004356	molecular_function	glutamine synthetase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006538	biological_process	L-glutamate catabolic process
B	0006542	biological_process	glutamine biosynthetic process
B	0008283	biological_process	cell population proliferation
B	0010594	biological_process	regulation of endothelial cell migration
B	0016740	molecular_function	transferase activity
B	0016874	molecular_function	ligase activity
B	0018345	biological_process	protein palmitoylation
B	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
B	0042254	biological_process	ribosome biogenesis
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0045648	biological_process	positive regulation of erythrocyte differentiation
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0097275	biological_process	intracellular ammonium homeostasis
B	0097386	cellular_component	glial cell projection
B	1903670	biological_process	regulation of sprouting angiogenesis
B	1904749	biological_process	regulation of protein localization to nucleolus
C	0000166	molecular_function	nucleotide binding
C	0001525	biological_process	angiogenesis
C	0003824	molecular_function	catalytic activity
C	0004356	molecular_function	glutamine synthetase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006538	biological_process	L-glutamate catabolic process
C	0006542	biological_process	glutamine biosynthetic process
C	0008283	biological_process	cell population proliferation
C	0010594	biological_process	regulation of endothelial cell migration
C	0016740	molecular_function	transferase activity
C	0016874	molecular_function	ligase activity
C	0018345	biological_process	protein palmitoylation
C	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
C	0042254	biological_process	ribosome biogenesis
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0097275	biological_process	intracellular ammonium homeostasis
C	0097386	cellular_component	glial cell projection
C	1903670	biological_process	regulation of sprouting angiogenesis
C	1904749	biological_process	regulation of protein localization to nucleolus
D	0000166	molecular_function	nucleotide binding
D	0001525	biological_process	angiogenesis
D	0003824	molecular_function	catalytic activity
D	0004356	molecular_function	glutamine synthetase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006538	biological_process	L-glutamate catabolic process
D	0006542	biological_process	glutamine biosynthetic process
D	0008283	biological_process	cell population proliferation
D	0010594	biological_process	regulation of endothelial cell migration
D	0016740	molecular_function	transferase activity
D	0016874	molecular_function	ligase activity
D	0018345	biological_process	protein palmitoylation
D	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
D	0042254	biological_process	ribosome biogenesis
D	0042802	molecular_function	identical protein binding
D	0044297	cellular_component	cell body
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0097275	biological_process	intracellular ammonium homeostasis
D	0097386	cellular_component	glial cell projection
D	1903670	biological_process	regulation of sprouting angiogenesis
D	1904749	biological_process	regulation of protein localization to nucleolus
E	0000166	molecular_function	nucleotide binding
E	0001525	biological_process	angiogenesis
E	0003824	molecular_function	catalytic activity
E	0004356	molecular_function	glutamine synthetase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006538	biological_process	L-glutamate catabolic process
E	0006542	biological_process	glutamine biosynthetic process
E	0008283	biological_process	cell population proliferation
E	0010594	biological_process	regulation of endothelial cell migration
E	0016740	molecular_function	transferase activity
E	0016874	molecular_function	ligase activity
E	0018345	biological_process	protein palmitoylation
E	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
E	0042254	biological_process	ribosome biogenesis
E	0042802	molecular_function	identical protein binding
E	0044297	cellular_component	cell body
E	0045648	biological_process	positive regulation of erythrocyte differentiation
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome
E	0097275	biological_process	intracellular ammonium homeostasis
E	0097386	cellular_component	glial cell projection
E	1903670	biological_process	regulation of sprouting angiogenesis
E	1904749	biological_process	regulation of protein localization to nucleolus
F	0000166	molecular_function	nucleotide binding
F	0001525	biological_process	angiogenesis
F	0003824	molecular_function	catalytic activity
F	0004356	molecular_function	glutamine synthetase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006538	biological_process	L-glutamate catabolic process
F	0006542	biological_process	glutamine biosynthetic process
F	0008283	biological_process	cell population proliferation
F	0010594	biological_process	regulation of endothelial cell migration
F	0016740	molecular_function	transferase activity
F	0016874	molecular_function	ligase activity
F	0018345	biological_process	protein palmitoylation
F	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
F	0042254	biological_process	ribosome biogenesis
F	0042802	molecular_function	identical protein binding
F	0044297	cellular_component	cell body
F	0045648	biological_process	positive regulation of erythrocyte differentiation
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0097275	biological_process	intracellular ammonium homeostasis
F	0097386	cellular_component	glial cell projection
F	1903670	biological_process	regulation of sprouting angiogenesis
F	1904749	biological_process	regulation of protein localization to nucleolus
G	0000166	molecular_function	nucleotide binding
G	0001525	biological_process	angiogenesis
G	0003824	molecular_function	catalytic activity
G	0004356	molecular_function	glutamine synthetase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006538	biological_process	L-glutamate catabolic process
G	0006542	biological_process	glutamine biosynthetic process
G	0008283	biological_process	cell population proliferation
G	0010594	biological_process	regulation of endothelial cell migration
G	0016740	molecular_function	transferase activity
G	0016874	molecular_function	ligase activity
G	0018345	biological_process	protein palmitoylation
G	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
G	0042254	biological_process	ribosome biogenesis
G	0042802	molecular_function	identical protein binding
G	0044297	cellular_component	cell body
G	0045648	biological_process	positive regulation of erythrocyte differentiation
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0097275	biological_process	intracellular ammonium homeostasis
G	0097386	cellular_component	glial cell projection
G	1903670	biological_process	regulation of sprouting angiogenesis
G	1904749	biological_process	regulation of protein localization to nucleolus
H	0000166	molecular_function	nucleotide binding
H	0001525	biological_process	angiogenesis
H	0003824	molecular_function	catalytic activity
H	0004356	molecular_function	glutamine synthetase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006538	biological_process	L-glutamate catabolic process
H	0006542	biological_process	glutamine biosynthetic process
H	0008283	biological_process	cell population proliferation
H	0010594	biological_process	regulation of endothelial cell migration
H	0016740	molecular_function	transferase activity
H	0016874	molecular_function	ligase activity
H	0018345	biological_process	protein palmitoylation
H	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
H	0042254	biological_process	ribosome biogenesis
H	0042802	molecular_function	identical protein binding
H	0044297	cellular_component	cell body
H	0045648	biological_process	positive regulation of erythrocyte differentiation
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	0097275	biological_process	intracellular ammonium homeostasis
H	0097386	cellular_component	glial cell projection
H	1903670	biological_process	regulation of sprouting angiogenesis
H	1904749	biological_process	regulation of protein localization to nucleolus
I	0000166	molecular_function	nucleotide binding
I	0001525	biological_process	angiogenesis
I	0003824	molecular_function	catalytic activity
I	0004356	molecular_function	glutamine synthetase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006538	biological_process	L-glutamate catabolic process
I	0006542	biological_process	glutamine biosynthetic process
I	0008283	biological_process	cell population proliferation
I	0010594	biological_process	regulation of endothelial cell migration
I	0016740	molecular_function	transferase activity
I	0016874	molecular_function	ligase activity
I	0018345	biological_process	protein palmitoylation
I	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
I	0042254	biological_process	ribosome biogenesis
I	0042802	molecular_function	identical protein binding
I	0044297	cellular_component	cell body
I	0045648	biological_process	positive regulation of erythrocyte differentiation
I	0046872	molecular_function	metal ion binding
I	0070062	cellular_component	extracellular exosome
I	0097275	biological_process	intracellular ammonium homeostasis
I	0097386	cellular_component	glial cell projection
I	1903670	biological_process	regulation of sprouting angiogenesis
I	1904749	biological_process	regulation of protein localization to nucleolus
J	0000166	molecular_function	nucleotide binding
J	0001525	biological_process	angiogenesis
J	0003824	molecular_function	catalytic activity
J	0004356	molecular_function	glutamine synthetase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006538	biological_process	L-glutamate catabolic process
J	0006542	biological_process	glutamine biosynthetic process
J	0008283	biological_process	cell population proliferation
J	0010594	biological_process	regulation of endothelial cell migration
J	0016740	molecular_function	transferase activity
J	0016874	molecular_function	ligase activity
J	0018345	biological_process	protein palmitoylation
J	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
J	0042254	biological_process	ribosome biogenesis
J	0042802	molecular_function	identical protein binding
J	0044297	cellular_component	cell body
J	0045648	biological_process	positive regulation of erythrocyte differentiation
J	0046872	molecular_function	metal ion binding
J	0070062	cellular_component	extracellular exosome
J	0097275	biological_process	intracellular ammonium homeostasis
J	0097386	cellular_component	glial cell projection
J	1903670	biological_process	regulation of sprouting angiogenesis
J	1904749	biological_process	regulation of protein localization to nucleolus

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 401

Chain	Residue
A	GLU136
A	GLU196
A	GLU203
A	MN403
A	P3S601
A	HOH704

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 402

Chain	Residue
A	ARG340
A	ADP501
A	P3S601
A	GLU134
A	HIS253
A	GLU338

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 403

Chain	Residue
A	GLU134
A	GLU203
A	MN401
A	ADP501
A	P3S601
A	HOH729

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 401

Chain	Residue
B	GLU136
B	GLU196
B	GLU203
B	MN403
B	P3S601
B	HOH744

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 402

Chain	Residue
B	GLU134
B	HIS253
B	GLU338
B	ARG340
B	MN403
B	ADP501
B	P3S601

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 403

Chain	Residue
B	GLU134
B	GLU203
B	MN401
B	MN402
B	ADP501
B	P3S601
B	HOH741

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 401

Chain	Residue
C	GLU136
C	GLU196
C	GLU203
C	MN403
C	P3S601
C	HOH740

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 402

Chain	Residue
C	GLU134
C	HIS253
C	GLU338
C	ARG340
C	ADP501
C	P3S601

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 403

Chain	Residue
C	GLU134
C	GLU203
C	MN401
C	ADP501
C	P3S601
C	HOH738

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 401

Chain	Residue
D	GLU136
D	GLU196
D	GLU203
D	MN403
D	P3S601

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 402

Chain	Residue
D	GLU134
D	HIS253
D	GLU338
D	ADP501
D	P3S601

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 403

Chain	Residue
D	GLU134
D	GLU203
D	MN401
D	ADP501
D	P3S601
D	HOH747

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 401

Chain	Residue
E	GLU136
E	GLU196
E	GLU203
E	P3S601
E	HOH629

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 402

Chain	Residue
E	GLU134
E	HIS253
E	GLU338
E	ARG340
E	ADP501
E	P3S601

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 403

Chain	Residue
E	GLU134
E	GLU203
E	ADP501
E	P3S601
E	HOH627

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN F 401

Chain	Residue
F	GLU136
F	GLU196
F	GLU203
F	MN403
F	P3S601

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 402

Chain	Residue
F	GLU134
F	HIS253
F	GLU338
F	ARG340
F	ADP501
F	P3S601

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 403

Chain	Residue
F	GLU134
F	GLU203
F	MN401
F	ADP501
F	P3S601
F	HOH717

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 401

Chain	Residue
G	GLU136
G	GLU196
G	GLU203
G	MN403
G	P3S601

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 402

Chain	Residue
G	GLU134
G	HIS253
G	GLU338
G	ADP501
G	P3S601

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 403

Chain	Residue
G	GLU134
G	GLU203
G	MN401
G	ADP501
G	P3S601

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 401

Chain	Residue
H	GLU136
H	GLU196
H	GLU203
H	MN403
H	P3S601
H	HOH609

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 402

Chain	Residue
H	GLU134
H	HIS253
H	GLU338
H	MN403
H	ADP501
H	P3S601

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN H 403

Chain	Residue
H	GLU134
H	GLU203
H	MN401
H	MN402
H	ADP501
H	P3S601
H	HOH608

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN I 401

Chain	Residue
I	GLU136
I	GLU196
I	GLU203
I	MN403
I	P3S601

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN I 402

Chain	Residue
I	GLU134
I	HIS253
I	GLU338
I	ARG340
I	ADP501
I	P3S601

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN I 403

Chain	Residue
I	GLU134
I	GLU203
I	MN401
I	ADP501
I	P3S601
I	HOH718

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN J 401

Chain	Residue
J	GLU136
J	GLU196
J	GLU203
J	MN403
J	P3S601
J	HOH718

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 402

Chain	Residue
J	GLU134
J	HIS253
J	GLU338
J	ADP501
J	P3S601

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN J 403

Chain	Residue
J	GLU134
J	GLU203
J	MN401
J	ADP501
J	P3S601
J	HOH717

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 701

Chain	Residue
B	MET29
B	THR44
C	THR193

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 702

Chain	Residue
C	MET29
C	THR44
D	THR193
D	HOH731

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 703

Chain	Residue
A	THR193
E	MET29
E	THR44

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 704

Chain	Residue
D	THR44
E	THR193

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 705

Chain	Residue
A	MET29
A	THR44
B	THR193

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 706

Chain	Residue
F	THR193
J	THR44

site_id	EC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 707

Chain	Residue
F	THR44
G	THR193

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G 708

Chain	Residue
G	MET29
G	LYS43
G	THR44
H	THR193

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL I 709

Chain	Residue
H	THR44
I	THR193

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL J 710

Chain	Residue
I	THR44
J	THR193

site_id	EC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP A 501

Chain	Residue
A	TRP130
A	GLY132
A	GLU134
A	GLU203
A	GLN205
A	GLY207
A	PRO208
A	ASN255
A	SER257
A	ARG262
A	ARG319
A	ARG324
A	TYR336
A	GLU338
A	MN402
A	MN403
A	P3S601
A	HOH729
A	HOH730
A	HOH731

site_id	EC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE P3S A 601

Chain	Residue
A	GLU134
A	GLU136
A	GLU196
A	GLU203
A	GLY249
A	HIS253
A	ARG299
A	GLU305
A	THR306
A	ARG319
A	GLU338
A	ARG340
A	MN401
A	MN402
A	MN403
A	ADP501
A	HOH704
A	HOH729
A	HOH733
E	ASP63

site_id	EC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP B 501

Chain	Residue
A	HOH732
B	TRP130
B	GLY132
B	GLU134
B	GLU203
B	GLN205
B	ILE206
B	GLY207
B	PRO208
B	ASN255
B	SER257
B	ARG319
B	ARG324
B	TYR336
B	GLU338
B	MN402
B	MN403
B	P3S601
B	HOH742

site_id	EC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE P3S B 601

Chain	Residue
A	ASP63
B	GLU134
B	GLU136
B	TYR162
B	GLU196
B	GLU203
B	GLY249
B	HIS253
B	ARG299
B	GLU305
B	THR306
B	ARG319
B	GLU338
B	ARG340
B	MN401
B	MN402
B	MN403
B	ADP501
B	HOH718
B	HOH744

site_id	EC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP C 501

Chain	Residue
C	TRP130
C	GLY132
C	GLU134
C	GLU203
C	GLN205
C	GLY207
C	PRO208
C	ASN255
C	SER257
C	ARG324
C	TYR336
C	GLU338
C	MN402
C	MN403
C	P3S601
C	HOH709
C	HOH736
C	HOH738
C	HOH739

site_id	FC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE P3S C 601

Chain	Residue
B	ASP63
C	GLU134
C	GLU136
C	TYR162
C	GLU196
C	GLU203
C	GLY249
C	HIS253
C	ARG299
C	GLU305
C	THR306
C	ARG319
C	GLU338
C	ARG340
C	MN401
C	MN402
C	MN403
C	ADP501
C	HOH704
C	HOH730
C	HOH740

site_id	FC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP D 501

Chain	Residue
C	HOH707
D	TRP130
D	GLY132
D	GLU134
D	GLU203
D	GLN205
D	GLY207
D	PRO208
D	ASN255
D	SER257
D	ARG319
D	ARG324
D	TYR336
D	GLU338
D	MN402
D	MN403
D	P3S601
D	HOH747

site_id	FC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE P3S D 601

Chain	Residue
C	ASP63
D	GLU134
D	GLU136
D	GLU196
D	GLU203
D	GLY249
D	HIS253
D	ARG299
D	GLU305
D	THR306
D	ARG319
D	GLU338
D	ARG340
D	MN401
D	MN402
D	MN403
D	ADP501
D	HOH711

site_id	FC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP E 501

Chain	Residue
D	HOH749
E	TRP130
E	GLY132
E	GLU134
E	GLU203
E	GLN205
E	GLY207
E	PRO208
E	ASN255
E	SER257
E	ARG319
E	ARG324
E	TYR336
E	GLU338
E	MN402
E	MN403
E	P3S601
E	HOH624
E	HOH627
E	HOH628

site_id	FC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE P3S E 601

Chain	Residue
D	ASP63
E	GLU134
E	GLU136
E	GLU196
E	GLU203
E	GLY249
E	HIS253
E	ARG299
E	GLU305
E	THR306
E	ARG319
E	GLU338
E	ARG340
E	MN401
E	MN402
E	MN403
E	ADP501
E	HOH629

site_id	FC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP F 501

Chain	Residue
F	TRP130
F	GLY132
F	GLU134
F	ALA191
F	GLU203
F	GLN205
F	ILE206
F	GLY207
F	PRO208
F	ASN255
F	SER257
F	ARG319
F	ARG324
F	TYR336
F	GLU338
F	MN402
F	MN403
F	P3S601
F	HOH717
F	HOH718

site_id	FC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE P3S F 601

Chain	Residue
F	GLU134
F	GLU136
F	GLU196
F	GLU203
F	GLY249
F	HIS253
F	ARG299
F	GLU305
F	THR306
F	ARG319
F	ARG340
F	MN401
F	MN402
F	MN403
F	ADP501
F	HOH712
F	HOH717
J	ASP63

site_id	FC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP G 501

Chain	Residue
G	TRP130
G	GLY132
G	GLU134
G	ALA191
G	GLU203
G	GLN205
G	ILE206
G	GLY207
G	PRO208
G	ASN255
G	SER257
G	ARG319
G	ARG324
G	TYR336
G	GLU338
G	MN402
G	MN403
G	P3S601

site_id	FC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE P3S G 601

Chain	Residue
F	ASP63
G	GLU134
G	GLU136
G	GLU196
G	GLU203
G	ASN248
G	GLY249
G	HIS253
G	ARG299
G	GLU305
G	THR306
G	ARG319
G	GLU338
G	ARG340
G	MN401
G	MN402
G	MN403
G	ADP501

site_id	GC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP H 501

Chain	Residue
H	GLY132
H	GLU134
H	ALA191
H	GLU203
H	GLN205
H	GLY207
H	PRO208
H	ASN255
H	SER257
H	ARG319
H	ARG324
H	TYR336
H	GLU338
H	MN402
H	MN403
H	P3S601
H	HOH608

site_id	GC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE P3S H 601

Chain	Residue
G	ASP63
H	GLU134
H	GLU136
H	TYR162
H	GLU196
H	GLU203
H	GLY249
H	HIS253
H	ARG299
H	GLU305
H	ARG319
H	GLU338
H	ARG340
H	MN401
H	MN402
H	MN403
H	ADP501
H	HOH608

site_id	GC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP I 501

Chain	Residue
I	TRP130
I	GLY132
I	GLU134
I	GLU203
I	GLN205
I	ILE206
I	GLY207
I	PRO208
I	ASN255
I	SER257
I	ARG319
I	ARG324
I	TYR336
I	GLU338
I	MN402
I	MN403
I	P3S601
I	HOH718
I	HOH719

site_id	GC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE P3S I 601

Chain	Residue
H	ASP63
I	GLU134
I	GLU136
I	GLU196
I	GLU203
I	ASN248
I	GLY249
I	GLY251
I	HIS253
I	ARG299
I	GLU305
I	ARG319
I	ARG324
I	GLU338
I	ARG340
I	MN401
I	MN402
I	MN403
I	ADP501

site_id	GC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP J 501

Chain	Residue
J	TRP130
J	GLY132
J	GLU134
J	ALA191
J	GLU203
J	GLN205
J	GLY207
J	PRO208
J	ASN255
J	SER257
J	ARG319
J	ARG324
J	TYR336
J	GLU338
J	MN402
J	MN403
J	P3S601
J	HOH717

site_id	GC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE P3S J 601

Chain	Residue
I	ASP63
J	GLU134
J	GLU136
J	TYR162
J	GLU196
J	GLU203
J	GLY249
J	HIS253
J	ARG299
J	GLU305
J	THR306
J	ARG319
J	GLU338
J	ARG340
J	MN401
J	MN402
J	MN403
J	ADP501
J	HOH714
J	HOH718

Functional Information from PROSITE/UniProt

site_id	PS00180
Number of Residues	18
Details	GLNA_1 Glutamine synthetase signature 1. FDGSStlqsegs.NSDmyL

Chain	Residue	Details
A	PHE62-LEU79

site_id	PS00181
Number of Residues	17
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS

Chain	Residue	Details
A	LYS241-SER257

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	820
Details	Domain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PDB","id":"2QC8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	100
Details	Binding site: {"evidences":[{"source":"PDB","id":"2OJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QC8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Modified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"PubMed","id":"26990986","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
A	ARG319
A	GLU305
A	ASP63

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
J	ARG319
J	GLU305
J	ASP63

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
B	ARG319
B	GLU305
B	ASP63

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
C	ARG319
C	GLU305
C	ASP63

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
D	ARG319
D	GLU305
D	ASP63

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
E	ARG319
E	GLU305
E	ASP63

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
F	ARG319
F	GLU305
F	ASP63

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
G	ARG319
G	GLU305
G	ASP63

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
H	ARG319
H	GLU305
H	ASP63

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
I	ARG319
I	GLU305
I	ASP63

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)