2QC8
Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001525 | biological_process | angiogenesis |
A | 0003824 | molecular_function | catalytic activity |
A | 0004356 | molecular_function | glutamine synthetase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006538 | biological_process | glutamate catabolic process |
A | 0006542 | biological_process | glutamine biosynthetic process |
A | 0008283 | biological_process | cell population proliferation |
A | 0009267 | biological_process | cellular response to starvation |
A | 0009749 | biological_process | response to glucose |
A | 0010594 | biological_process | regulation of endothelial cell migration |
A | 0016740 | molecular_function | transferase activity |
A | 0016874 | molecular_function | ligase activity |
A | 0018345 | biological_process | protein palmitoylation |
A | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
A | 0042254 | biological_process | ribosome biogenesis |
A | 0042802 | molecular_function | identical protein binding |
A | 0044297 | cellular_component | cell body |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0097386 | cellular_component | glial cell projection |
A | 1903670 | biological_process | regulation of sprouting angiogenesis |
A | 1904749 | biological_process | regulation of protein localization to nucleolus |
B | 0001525 | biological_process | angiogenesis |
B | 0003824 | molecular_function | catalytic activity |
B | 0004356 | molecular_function | glutamine synthetase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006538 | biological_process | glutamate catabolic process |
B | 0006542 | biological_process | glutamine biosynthetic process |
B | 0008283 | biological_process | cell population proliferation |
B | 0009267 | biological_process | cellular response to starvation |
B | 0009749 | biological_process | response to glucose |
B | 0010594 | biological_process | regulation of endothelial cell migration |
B | 0016740 | molecular_function | transferase activity |
B | 0016874 | molecular_function | ligase activity |
B | 0018345 | biological_process | protein palmitoylation |
B | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
B | 0042254 | biological_process | ribosome biogenesis |
B | 0042802 | molecular_function | identical protein binding |
B | 0044297 | cellular_component | cell body |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0097386 | cellular_component | glial cell projection |
B | 1903670 | biological_process | regulation of sprouting angiogenesis |
B | 1904749 | biological_process | regulation of protein localization to nucleolus |
C | 0001525 | biological_process | angiogenesis |
C | 0003824 | molecular_function | catalytic activity |
C | 0004356 | molecular_function | glutamine synthetase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005783 | cellular_component | endoplasmic reticulum |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0006538 | biological_process | glutamate catabolic process |
C | 0006542 | biological_process | glutamine biosynthetic process |
C | 0008283 | biological_process | cell population proliferation |
C | 0009267 | biological_process | cellular response to starvation |
C | 0009749 | biological_process | response to glucose |
C | 0010594 | biological_process | regulation of endothelial cell migration |
C | 0016740 | molecular_function | transferase activity |
C | 0016874 | molecular_function | ligase activity |
C | 0018345 | biological_process | protein palmitoylation |
C | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
C | 0042254 | biological_process | ribosome biogenesis |
C | 0042802 | molecular_function | identical protein binding |
C | 0044297 | cellular_component | cell body |
C | 0046872 | molecular_function | metal ion binding |
C | 0070062 | cellular_component | extracellular exosome |
C | 0097386 | cellular_component | glial cell projection |
C | 1903670 | biological_process | regulation of sprouting angiogenesis |
C | 1904749 | biological_process | regulation of protein localization to nucleolus |
D | 0001525 | biological_process | angiogenesis |
D | 0003824 | molecular_function | catalytic activity |
D | 0004356 | molecular_function | glutamine synthetase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005739 | cellular_component | mitochondrion |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005829 | cellular_component | cytosol |
D | 0005886 | cellular_component | plasma membrane |
D | 0006538 | biological_process | glutamate catabolic process |
D | 0006542 | biological_process | glutamine biosynthetic process |
D | 0008283 | biological_process | cell population proliferation |
D | 0009267 | biological_process | cellular response to starvation |
D | 0009749 | biological_process | response to glucose |
D | 0010594 | biological_process | regulation of endothelial cell migration |
D | 0016740 | molecular_function | transferase activity |
D | 0016874 | molecular_function | ligase activity |
D | 0018345 | biological_process | protein palmitoylation |
D | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
D | 0042254 | biological_process | ribosome biogenesis |
D | 0042802 | molecular_function | identical protein binding |
D | 0044297 | cellular_component | cell body |
D | 0046872 | molecular_function | metal ion binding |
D | 0070062 | cellular_component | extracellular exosome |
D | 0097386 | cellular_component | glial cell projection |
D | 1903670 | biological_process | regulation of sprouting angiogenesis |
D | 1904749 | biological_process | regulation of protein localization to nucleolus |
E | 0001525 | biological_process | angiogenesis |
E | 0003824 | molecular_function | catalytic activity |
E | 0004356 | molecular_function | glutamine synthetase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005634 | cellular_component | nucleus |
E | 0005737 | cellular_component | cytoplasm |
E | 0005739 | cellular_component | mitochondrion |
E | 0005783 | cellular_component | endoplasmic reticulum |
E | 0005829 | cellular_component | cytosol |
E | 0005886 | cellular_component | plasma membrane |
E | 0006538 | biological_process | glutamate catabolic process |
E | 0006542 | biological_process | glutamine biosynthetic process |
E | 0008283 | biological_process | cell population proliferation |
E | 0009267 | biological_process | cellular response to starvation |
E | 0009749 | biological_process | response to glucose |
E | 0010594 | biological_process | regulation of endothelial cell migration |
E | 0016740 | molecular_function | transferase activity |
E | 0016874 | molecular_function | ligase activity |
E | 0018345 | biological_process | protein palmitoylation |
E | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
E | 0042254 | biological_process | ribosome biogenesis |
E | 0042802 | molecular_function | identical protein binding |
E | 0044297 | cellular_component | cell body |
E | 0046872 | molecular_function | metal ion binding |
E | 0070062 | cellular_component | extracellular exosome |
E | 0097386 | cellular_component | glial cell projection |
E | 1903670 | biological_process | regulation of sprouting angiogenesis |
E | 1904749 | biological_process | regulation of protein localization to nucleolus |
F | 0001525 | biological_process | angiogenesis |
F | 0003824 | molecular_function | catalytic activity |
F | 0004356 | molecular_function | glutamine synthetase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005524 | molecular_function | ATP binding |
F | 0005634 | cellular_component | nucleus |
F | 0005737 | cellular_component | cytoplasm |
F | 0005739 | cellular_component | mitochondrion |
F | 0005783 | cellular_component | endoplasmic reticulum |
F | 0005829 | cellular_component | cytosol |
F | 0005886 | cellular_component | plasma membrane |
F | 0006538 | biological_process | glutamate catabolic process |
F | 0006542 | biological_process | glutamine biosynthetic process |
F | 0008283 | biological_process | cell population proliferation |
F | 0009267 | biological_process | cellular response to starvation |
F | 0009749 | biological_process | response to glucose |
F | 0010594 | biological_process | regulation of endothelial cell migration |
F | 0016740 | molecular_function | transferase activity |
F | 0016874 | molecular_function | ligase activity |
F | 0018345 | biological_process | protein palmitoylation |
F | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
F | 0042254 | biological_process | ribosome biogenesis |
F | 0042802 | molecular_function | identical protein binding |
F | 0044297 | cellular_component | cell body |
F | 0046872 | molecular_function | metal ion binding |
F | 0070062 | cellular_component | extracellular exosome |
F | 0097386 | cellular_component | glial cell projection |
F | 1903670 | biological_process | regulation of sprouting angiogenesis |
F | 1904749 | biological_process | regulation of protein localization to nucleolus |
G | 0001525 | biological_process | angiogenesis |
G | 0003824 | molecular_function | catalytic activity |
G | 0004356 | molecular_function | glutamine synthetase activity |
G | 0005515 | molecular_function | protein binding |
G | 0005524 | molecular_function | ATP binding |
G | 0005634 | cellular_component | nucleus |
G | 0005737 | cellular_component | cytoplasm |
G | 0005739 | cellular_component | mitochondrion |
G | 0005783 | cellular_component | endoplasmic reticulum |
G | 0005829 | cellular_component | cytosol |
G | 0005886 | cellular_component | plasma membrane |
G | 0006538 | biological_process | glutamate catabolic process |
G | 0006542 | biological_process | glutamine biosynthetic process |
G | 0008283 | biological_process | cell population proliferation |
G | 0009267 | biological_process | cellular response to starvation |
G | 0009749 | biological_process | response to glucose |
G | 0010594 | biological_process | regulation of endothelial cell migration |
G | 0016740 | molecular_function | transferase activity |
G | 0016874 | molecular_function | ligase activity |
G | 0018345 | biological_process | protein palmitoylation |
G | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
G | 0042254 | biological_process | ribosome biogenesis |
G | 0042802 | molecular_function | identical protein binding |
G | 0044297 | cellular_component | cell body |
G | 0046872 | molecular_function | metal ion binding |
G | 0070062 | cellular_component | extracellular exosome |
G | 0097386 | cellular_component | glial cell projection |
G | 1903670 | biological_process | regulation of sprouting angiogenesis |
G | 1904749 | biological_process | regulation of protein localization to nucleolus |
H | 0001525 | biological_process | angiogenesis |
H | 0003824 | molecular_function | catalytic activity |
H | 0004356 | molecular_function | glutamine synthetase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005524 | molecular_function | ATP binding |
H | 0005634 | cellular_component | nucleus |
H | 0005737 | cellular_component | cytoplasm |
H | 0005739 | cellular_component | mitochondrion |
H | 0005783 | cellular_component | endoplasmic reticulum |
H | 0005829 | cellular_component | cytosol |
H | 0005886 | cellular_component | plasma membrane |
H | 0006538 | biological_process | glutamate catabolic process |
H | 0006542 | biological_process | glutamine biosynthetic process |
H | 0008283 | biological_process | cell population proliferation |
H | 0009267 | biological_process | cellular response to starvation |
H | 0009749 | biological_process | response to glucose |
H | 0010594 | biological_process | regulation of endothelial cell migration |
H | 0016740 | molecular_function | transferase activity |
H | 0016874 | molecular_function | ligase activity |
H | 0018345 | biological_process | protein palmitoylation |
H | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
H | 0042254 | biological_process | ribosome biogenesis |
H | 0042802 | molecular_function | identical protein binding |
H | 0044297 | cellular_component | cell body |
H | 0046872 | molecular_function | metal ion binding |
H | 0070062 | cellular_component | extracellular exosome |
H | 0097386 | cellular_component | glial cell projection |
H | 1903670 | biological_process | regulation of sprouting angiogenesis |
H | 1904749 | biological_process | regulation of protein localization to nucleolus |
I | 0001525 | biological_process | angiogenesis |
I | 0003824 | molecular_function | catalytic activity |
I | 0004356 | molecular_function | glutamine synthetase activity |
I | 0005515 | molecular_function | protein binding |
I | 0005524 | molecular_function | ATP binding |
I | 0005634 | cellular_component | nucleus |
I | 0005737 | cellular_component | cytoplasm |
I | 0005739 | cellular_component | mitochondrion |
I | 0005783 | cellular_component | endoplasmic reticulum |
I | 0005829 | cellular_component | cytosol |
I | 0005886 | cellular_component | plasma membrane |
I | 0006538 | biological_process | glutamate catabolic process |
I | 0006542 | biological_process | glutamine biosynthetic process |
I | 0008283 | biological_process | cell population proliferation |
I | 0009267 | biological_process | cellular response to starvation |
I | 0009749 | biological_process | response to glucose |
I | 0010594 | biological_process | regulation of endothelial cell migration |
I | 0016740 | molecular_function | transferase activity |
I | 0016874 | molecular_function | ligase activity |
I | 0018345 | biological_process | protein palmitoylation |
I | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
I | 0042254 | biological_process | ribosome biogenesis |
I | 0042802 | molecular_function | identical protein binding |
I | 0044297 | cellular_component | cell body |
I | 0046872 | molecular_function | metal ion binding |
I | 0070062 | cellular_component | extracellular exosome |
I | 0097386 | cellular_component | glial cell projection |
I | 1903670 | biological_process | regulation of sprouting angiogenesis |
I | 1904749 | biological_process | regulation of protein localization to nucleolus |
J | 0001525 | biological_process | angiogenesis |
J | 0003824 | molecular_function | catalytic activity |
J | 0004356 | molecular_function | glutamine synthetase activity |
J | 0005515 | molecular_function | protein binding |
J | 0005524 | molecular_function | ATP binding |
J | 0005634 | cellular_component | nucleus |
J | 0005737 | cellular_component | cytoplasm |
J | 0005739 | cellular_component | mitochondrion |
J | 0005783 | cellular_component | endoplasmic reticulum |
J | 0005829 | cellular_component | cytosol |
J | 0005886 | cellular_component | plasma membrane |
J | 0006538 | biological_process | glutamate catabolic process |
J | 0006542 | biological_process | glutamine biosynthetic process |
J | 0008283 | biological_process | cell population proliferation |
J | 0009267 | biological_process | cellular response to starvation |
J | 0009749 | biological_process | response to glucose |
J | 0010594 | biological_process | regulation of endothelial cell migration |
J | 0016740 | molecular_function | transferase activity |
J | 0016874 | molecular_function | ligase activity |
J | 0018345 | biological_process | protein palmitoylation |
J | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
J | 0042254 | biological_process | ribosome biogenesis |
J | 0042802 | molecular_function | identical protein binding |
J | 0044297 | cellular_component | cell body |
J | 0046872 | molecular_function | metal ion binding |
J | 0070062 | cellular_component | extracellular exosome |
J | 0097386 | cellular_component | glial cell projection |
J | 1903670 | biological_process | regulation of sprouting angiogenesis |
J | 1904749 | biological_process | regulation of protein localization to nucleolus |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 401 |
Chain | Residue |
A | GLU136 |
A | GLU196 |
A | GLU203 |
A | MN403 |
A | P3S601 |
A | HOH704 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 402 |
Chain | Residue |
A | ARG340 |
A | ADP501 |
A | P3S601 |
A | GLU134 |
A | HIS253 |
A | GLU338 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 403 |
Chain | Residue |
A | GLU134 |
A | GLU203 |
A | MN401 |
A | ADP501 |
A | P3S601 |
A | HOH729 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN B 401 |
Chain | Residue |
B | GLU136 |
B | GLU196 |
B | GLU203 |
B | MN403 |
B | P3S601 |
B | HOH744 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MN B 402 |
Chain | Residue |
B | GLU134 |
B | HIS253 |
B | GLU338 |
B | ARG340 |
B | MN403 |
B | ADP501 |
B | P3S601 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MN B 403 |
Chain | Residue |
B | GLU134 |
B | GLU203 |
B | MN401 |
B | MN402 |
B | ADP501 |
B | P3S601 |
B | HOH741 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN C 401 |
Chain | Residue |
C | GLU136 |
C | GLU196 |
C | GLU203 |
C | MN403 |
C | P3S601 |
C | HOH740 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN C 402 |
Chain | Residue |
C | GLU134 |
C | HIS253 |
C | GLU338 |
C | ARG340 |
C | ADP501 |
C | P3S601 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN C 403 |
Chain | Residue |
C | GLU134 |
C | GLU203 |
C | MN401 |
C | ADP501 |
C | P3S601 |
C | HOH738 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN D 401 |
Chain | Residue |
D | GLU136 |
D | GLU196 |
D | GLU203 |
D | MN403 |
D | P3S601 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN D 402 |
Chain | Residue |
D | GLU134 |
D | HIS253 |
D | GLU338 |
D | ADP501 |
D | P3S601 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN D 403 |
Chain | Residue |
D | GLU134 |
D | GLU203 |
D | MN401 |
D | ADP501 |
D | P3S601 |
D | HOH747 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN E 401 |
Chain | Residue |
E | GLU136 |
E | GLU196 |
E | GLU203 |
E | P3S601 |
E | HOH629 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN E 402 |
Chain | Residue |
E | GLU134 |
E | HIS253 |
E | GLU338 |
E | ARG340 |
E | ADP501 |
E | P3S601 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN E 403 |
Chain | Residue |
E | GLU134 |
E | GLU203 |
E | ADP501 |
E | P3S601 |
E | HOH627 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN F 401 |
Chain | Residue |
F | GLU136 |
F | GLU196 |
F | GLU203 |
F | MN403 |
F | P3S601 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN F 402 |
Chain | Residue |
F | GLU134 |
F | HIS253 |
F | GLU338 |
F | ARG340 |
F | ADP501 |
F | P3S601 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN F 403 |
Chain | Residue |
F | GLU134 |
F | GLU203 |
F | MN401 |
F | ADP501 |
F | P3S601 |
F | HOH717 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN G 401 |
Chain | Residue |
G | GLU136 |
G | GLU196 |
G | GLU203 |
G | MN403 |
G | P3S601 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN G 402 |
Chain | Residue |
G | GLU134 |
G | HIS253 |
G | GLU338 |
G | ADP501 |
G | P3S601 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN G 403 |
Chain | Residue |
G | GLU134 |
G | GLU203 |
G | MN401 |
G | ADP501 |
G | P3S601 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN H 401 |
Chain | Residue |
H | GLU136 |
H | GLU196 |
H | GLU203 |
H | MN403 |
H | P3S601 |
H | HOH609 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN H 402 |
Chain | Residue |
H | GLU134 |
H | HIS253 |
H | GLU338 |
H | MN403 |
H | ADP501 |
H | P3S601 |
site_id | CC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MN H 403 |
Chain | Residue |
H | GLU134 |
H | GLU203 |
H | MN401 |
H | MN402 |
H | ADP501 |
H | P3S601 |
H | HOH608 |
site_id | CC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN I 401 |
Chain | Residue |
I | GLU136 |
I | GLU196 |
I | GLU203 |
I | MN403 |
I | P3S601 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN I 402 |
Chain | Residue |
I | GLU134 |
I | HIS253 |
I | GLU338 |
I | ARG340 |
I | ADP501 |
I | P3S601 |
site_id | CC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN I 403 |
Chain | Residue |
I | GLU134 |
I | GLU203 |
I | MN401 |
I | ADP501 |
I | P3S601 |
I | HOH718 |
site_id | DC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN J 401 |
Chain | Residue |
J | GLU136 |
J | GLU196 |
J | GLU203 |
J | MN403 |
J | P3S601 |
J | HOH718 |
site_id | DC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN J 402 |
Chain | Residue |
J | GLU134 |
J | HIS253 |
J | GLU338 |
J | ADP501 |
J | P3S601 |
site_id | DC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN J 403 |
Chain | Residue |
J | GLU134 |
J | GLU203 |
J | MN401 |
J | ADP501 |
J | P3S601 |
J | HOH717 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 701 |
Chain | Residue |
B | MET29 |
B | THR44 |
C | THR193 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL C 702 |
Chain | Residue |
C | MET29 |
C | THR44 |
D | THR193 |
D | HOH731 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 703 |
Chain | Residue |
A | THR193 |
E | MET29 |
E | THR44 |
site_id | DC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL D 704 |
Chain | Residue |
D | THR44 |
E | THR193 |
site_id | DC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 705 |
Chain | Residue |
A | MET29 |
A | THR44 |
B | THR193 |
site_id | DC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL F 706 |
Chain | Residue |
F | THR193 |
J | THR44 |
site_id | EC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL G 707 |
Chain | Residue |
F | THR44 |
G | THR193 |
site_id | EC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL G 708 |
Chain | Residue |
G | MET29 |
G | LYS43 |
G | THR44 |
H | THR193 |
site_id | EC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL I 709 |
Chain | Residue |
H | THR44 |
I | THR193 |
site_id | EC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL J 710 |
Chain | Residue |
I | THR44 |
J | THR193 |
site_id | EC5 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ADP A 501 |
Chain | Residue |
A | TRP130 |
A | GLY132 |
A | GLU134 |
A | GLU203 |
A | GLN205 |
A | GLY207 |
A | PRO208 |
A | ASN255 |
A | SER257 |
A | ARG262 |
A | ARG319 |
A | ARG324 |
A | TYR336 |
A | GLU338 |
A | MN402 |
A | MN403 |
A | P3S601 |
A | HOH729 |
A | HOH730 |
A | HOH731 |
site_id | EC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE P3S A 601 |
Chain | Residue |
A | GLU134 |
A | GLU136 |
A | GLU196 |
A | GLU203 |
A | GLY249 |
A | HIS253 |
A | ARG299 |
A | GLU305 |
A | THR306 |
A | ARG319 |
A | GLU338 |
A | ARG340 |
A | MN401 |
A | MN402 |
A | MN403 |
A | ADP501 |
A | HOH704 |
A | HOH729 |
A | HOH733 |
E | ASP63 |
site_id | EC7 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE ADP B 501 |
Chain | Residue |
A | HOH732 |
B | TRP130 |
B | GLY132 |
B | GLU134 |
B | GLU203 |
B | GLN205 |
B | ILE206 |
B | GLY207 |
B | PRO208 |
B | ASN255 |
B | SER257 |
B | ARG319 |
B | ARG324 |
B | TYR336 |
B | GLU338 |
B | MN402 |
B | MN403 |
B | P3S601 |
B | HOH742 |
site_id | EC8 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE P3S B 601 |
Chain | Residue |
A | ASP63 |
B | GLU134 |
B | GLU136 |
B | TYR162 |
B | GLU196 |
B | GLU203 |
B | GLY249 |
B | HIS253 |
B | ARG299 |
B | GLU305 |
B | THR306 |
B | ARG319 |
B | GLU338 |
B | ARG340 |
B | MN401 |
B | MN402 |
B | MN403 |
B | ADP501 |
B | HOH718 |
B | HOH744 |
site_id | EC9 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE ADP C 501 |
Chain | Residue |
C | TRP130 |
C | GLY132 |
C | GLU134 |
C | GLU203 |
C | GLN205 |
C | GLY207 |
C | PRO208 |
C | ASN255 |
C | SER257 |
C | ARG324 |
C | TYR336 |
C | GLU338 |
C | MN402 |
C | MN403 |
C | P3S601 |
C | HOH709 |
C | HOH736 |
C | HOH738 |
C | HOH739 |
site_id | FC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE P3S C 601 |
Chain | Residue |
B | ASP63 |
C | GLU134 |
C | GLU136 |
C | TYR162 |
C | GLU196 |
C | GLU203 |
C | GLY249 |
C | HIS253 |
C | ARG299 |
C | GLU305 |
C | THR306 |
C | ARG319 |
C | GLU338 |
C | ARG340 |
C | MN401 |
C | MN402 |
C | MN403 |
C | ADP501 |
C | HOH704 |
C | HOH730 |
C | HOH740 |
site_id | FC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ADP D 501 |
Chain | Residue |
C | HOH707 |
D | TRP130 |
D | GLY132 |
D | GLU134 |
D | GLU203 |
D | GLN205 |
D | GLY207 |
D | PRO208 |
D | ASN255 |
D | SER257 |
D | ARG319 |
D | ARG324 |
D | TYR336 |
D | GLU338 |
D | MN402 |
D | MN403 |
D | P3S601 |
D | HOH747 |
site_id | FC3 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE P3S D 601 |
Chain | Residue |
C | ASP63 |
D | GLU134 |
D | GLU136 |
D | GLU196 |
D | GLU203 |
D | GLY249 |
D | HIS253 |
D | ARG299 |
D | GLU305 |
D | THR306 |
D | ARG319 |
D | GLU338 |
D | ARG340 |
D | MN401 |
D | MN402 |
D | MN403 |
D | ADP501 |
D | HOH711 |
site_id | FC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ADP E 501 |
Chain | Residue |
D | HOH749 |
E | TRP130 |
E | GLY132 |
E | GLU134 |
E | GLU203 |
E | GLN205 |
E | GLY207 |
E | PRO208 |
E | ASN255 |
E | SER257 |
E | ARG319 |
E | ARG324 |
E | TYR336 |
E | GLU338 |
E | MN402 |
E | MN403 |
E | P3S601 |
E | HOH624 |
E | HOH627 |
E | HOH628 |
site_id | FC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE P3S E 601 |
Chain | Residue |
D | ASP63 |
E | GLU134 |
E | GLU136 |
E | GLU196 |
E | GLU203 |
E | GLY249 |
E | HIS253 |
E | ARG299 |
E | GLU305 |
E | THR306 |
E | ARG319 |
E | GLU338 |
E | ARG340 |
E | MN401 |
E | MN402 |
E | MN403 |
E | ADP501 |
E | HOH629 |
site_id | FC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ADP F 501 |
Chain | Residue |
F | TRP130 |
F | GLY132 |
F | GLU134 |
F | ALA191 |
F | GLU203 |
F | GLN205 |
F | ILE206 |
F | GLY207 |
F | PRO208 |
F | ASN255 |
F | SER257 |
F | ARG319 |
F | ARG324 |
F | TYR336 |
F | GLU338 |
F | MN402 |
F | MN403 |
F | P3S601 |
F | HOH717 |
F | HOH718 |
site_id | FC7 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE P3S F 601 |
Chain | Residue |
F | GLU134 |
F | GLU136 |
F | GLU196 |
F | GLU203 |
F | GLY249 |
F | HIS253 |
F | ARG299 |
F | GLU305 |
F | THR306 |
F | ARG319 |
F | ARG340 |
F | MN401 |
F | MN402 |
F | MN403 |
F | ADP501 |
F | HOH712 |
F | HOH717 |
J | ASP63 |
site_id | FC8 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ADP G 501 |
Chain | Residue |
G | TRP130 |
G | GLY132 |
G | GLU134 |
G | ALA191 |
G | GLU203 |
G | GLN205 |
G | ILE206 |
G | GLY207 |
G | PRO208 |
G | ASN255 |
G | SER257 |
G | ARG319 |
G | ARG324 |
G | TYR336 |
G | GLU338 |
G | MN402 |
G | MN403 |
G | P3S601 |
site_id | FC9 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE P3S G 601 |
Chain | Residue |
F | ASP63 |
G | GLU134 |
G | GLU136 |
G | GLU196 |
G | GLU203 |
G | ASN248 |
G | GLY249 |
G | HIS253 |
G | ARG299 |
G | GLU305 |
G | THR306 |
G | ARG319 |
G | GLU338 |
G | ARG340 |
G | MN401 |
G | MN402 |
G | MN403 |
G | ADP501 |
site_id | GC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ADP H 501 |
Chain | Residue |
H | GLY132 |
H | GLU134 |
H | ALA191 |
H | GLU203 |
H | GLN205 |
H | GLY207 |
H | PRO208 |
H | ASN255 |
H | SER257 |
H | ARG319 |
H | ARG324 |
H | TYR336 |
H | GLU338 |
H | MN402 |
H | MN403 |
H | P3S601 |
H | HOH608 |
site_id | GC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE P3S H 601 |
Chain | Residue |
G | ASP63 |
H | GLU134 |
H | GLU136 |
H | TYR162 |
H | GLU196 |
H | GLU203 |
H | GLY249 |
H | HIS253 |
H | ARG299 |
H | GLU305 |
H | ARG319 |
H | GLU338 |
H | ARG340 |
H | MN401 |
H | MN402 |
H | MN403 |
H | ADP501 |
H | HOH608 |
site_id | GC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE ADP I 501 |
Chain | Residue |
I | TRP130 |
I | GLY132 |
I | GLU134 |
I | GLU203 |
I | GLN205 |
I | ILE206 |
I | GLY207 |
I | PRO208 |
I | ASN255 |
I | SER257 |
I | ARG319 |
I | ARG324 |
I | TYR336 |
I | GLU338 |
I | MN402 |
I | MN403 |
I | P3S601 |
I | HOH718 |
I | HOH719 |
site_id | GC4 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE P3S I 601 |
Chain | Residue |
H | ASP63 |
I | GLU134 |
I | GLU136 |
I | GLU196 |
I | GLU203 |
I | ASN248 |
I | GLY249 |
I | GLY251 |
I | HIS253 |
I | ARG299 |
I | GLU305 |
I | ARG319 |
I | ARG324 |
I | GLU338 |
I | ARG340 |
I | MN401 |
I | MN402 |
I | MN403 |
I | ADP501 |
site_id | GC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ADP J 501 |
Chain | Residue |
J | TRP130 |
J | GLY132 |
J | GLU134 |
J | ALA191 |
J | GLU203 |
J | GLN205 |
J | GLY207 |
J | PRO208 |
J | ASN255 |
J | SER257 |
J | ARG319 |
J | ARG324 |
J | TYR336 |
J | GLU338 |
J | MN402 |
J | MN403 |
J | P3S601 |
J | HOH717 |
site_id | GC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE P3S J 601 |
Chain | Residue |
I | ASP63 |
J | GLU134 |
J | GLU136 |
J | TYR162 |
J | GLU196 |
J | GLU203 |
J | GLY249 |
J | HIS253 |
J | ARG299 |
J | GLU305 |
J | THR306 |
J | ARG319 |
J | GLU338 |
J | ARG340 |
J | MN401 |
J | MN402 |
J | MN403 |
J | ADP501 |
J | HOH714 |
J | HOH718 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 60 |
Details | BINDING: BINDING => ECO:0007744|PDB:2QC8 |
Chain | Residue | Details |
A | GLU134 | |
B | GLU203 | |
B | HIS253 | |
B | GLU338 | |
C | GLU134 | |
C | GLU136 | |
C | GLU196 | |
C | GLU203 | |
C | HIS253 | |
C | GLU338 | |
D | GLU134 | |
A | GLU136 | |
D | GLU136 | |
D | GLU196 | |
D | GLU203 | |
D | HIS253 | |
D | GLU338 | |
E | GLU134 | |
E | GLU136 | |
E | GLU196 | |
E | GLU203 | |
E | HIS253 | |
A | GLU196 | |
E | GLU338 | |
F | GLU134 | |
F | GLU136 | |
F | GLU196 | |
F | GLU203 | |
F | HIS253 | |
F | GLU338 | |
G | GLU134 | |
G | GLU136 | |
G | GLU196 | |
A | GLU203 | |
G | GLU203 | |
G | HIS253 | |
G | GLU338 | |
H | GLU134 | |
H | GLU136 | |
H | GLU196 | |
H | GLU203 | |
H | HIS253 | |
H | GLU338 | |
I | GLU134 | |
A | HIS253 | |
I | GLU136 | |
I | GLU196 | |
I | GLU203 | |
I | HIS253 | |
I | GLU338 | |
J | GLU134 | |
J | GLU136 | |
J | GLU196 | |
J | GLU203 | |
J | HIS253 | |
A | GLU338 | |
J | GLU338 | |
B | GLU134 | |
B | GLU136 | |
B | GLU196 |
site_id | SWS_FT_FI2 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P9WN39 |
Chain | Residue | Details |
A | ASN246 | |
D | ASN246 | |
D | ARG319 | |
D | ARG340 | |
E | ASN246 | |
E | ARG319 | |
E | ARG340 | |
F | ASN246 | |
F | ARG319 | |
F | ARG340 | |
G | ASN246 | |
A | ARG319 | |
G | ARG319 | |
G | ARG340 | |
H | ASN246 | |
H | ARG319 | |
H | ARG340 | |
I | ASN246 | |
I | ARG319 | |
I | ARG340 | |
J | ASN246 | |
J | ARG319 | |
A | ARG340 | |
J | ARG340 | |
B | ASN246 | |
B | ARG319 | |
B | ARG340 | |
C | ASN246 | |
C | ARG319 | |
C | ARG340 |
site_id | SWS_FT_FI3 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 |
Chain | Residue | Details |
A | ASN255 | |
D | ASN255 | |
D | ARG324 | |
D | TYR336 | |
E | ASN255 | |
E | ARG324 | |
E | TYR336 | |
F | ASN255 | |
F | ARG324 | |
F | TYR336 | |
G | ASN255 | |
A | ARG324 | |
G | ARG324 | |
G | TYR336 | |
H | ASN255 | |
H | ARG324 | |
H | TYR336 | |
I | ASN255 | |
I | ARG324 | |
I | TYR336 | |
J | ASN255 | |
J | ARG324 | |
A | TYR336 | |
J | TYR336 | |
B | ASN255 | |
B | ARG324 | |
B | TYR336 | |
C | ASN255 | |
C | ARG324 | |
C | TYR336 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P15105 |
Chain | Residue | Details |
A | TYR104 | |
J | TYR104 | |
B | TYR104 | |
C | TYR104 | |
D | TYR104 | |
E | TYR104 | |
F | TYR104 | |
G | TYR104 | |
H | TYR104 | |
I | TYR104 |
site_id | SWS_FT_FI5 |
Number of Residues | 10 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER343 | |
J | SER343 | |
B | SER343 | |
C | SER343 | |
D | SER343 | |
E | SER343 | |
F | SER343 | |
G | SER343 | |
H | SER343 | |
I | SER343 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
A | ARG319 | |
A | GLU305 | |
A | ASP63 |
site_id | CSA10 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
J | ARG319 | |
J | GLU305 | |
J | ASP63 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
B | ARG319 | |
B | GLU305 | |
B | ASP63 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
C | ARG319 | |
C | GLU305 | |
C | ASP63 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
D | ARG319 | |
D | GLU305 | |
D | ASP63 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
E | ARG319 | |
E | GLU305 | |
E | ASP63 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
F | ARG319 | |
F | GLU305 | |
F | ASP63 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
G | ARG319 | |
G | GLU305 | |
G | ASP63 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
H | ARG319 | |
H | GLU305 | |
H | ASP63 |
site_id | CSA9 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1hto |
Chain | Residue | Details |
I | ARG319 | |
I | GLU305 | |
I | ASP63 |