2JGA

Crystal structure of human cytosolic 5'-nucleotidase III in complex with phosphate and magnesium

Summary for 2JGA

• Entry DOI: 10.2210/pdb2jga/pdb
• Related: 2CN1
• Descriptor: CYTOSOLIC 5'-NUCLEOTIDASE III, PHOSPHATE ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: pyrimidine 5-prime- nucleotidase 1, nucleotide metabolism, pyrimidine 5-prime nucleotidase deficiency, uridine 5-prime monophosphate hydrolase 1, cytosolic iii, disease mutation, nucleotide-binding, p5n1, umph1, 5-prime, hydrolase, nucleotidase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm (Potential). Isoform 2: Endoplasmic reticulum: Q9H0P0
• Total number of polymer chains: 1
• Total formula weight: 33346.31

Authors

Wallden, K.,Stenmark, P.,Arrowsmith, C.,Berglund, H.,Collins, R.,Edwards, A.,Ehn, M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, M.,Holmberg, B.,Schiavone, L.,Hogbom, M.,Kotenyova, T.,Magnusdottir, A.,Nilsson-Ehle, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Sundstrom, M.,Thorsell, A.G.,Uppenberg, J.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Nordlund, P. (deposition date: 2007-02-09, release date: 2007-04-03, Last modification date: 2023-12-13)

• Primary citation: Wallden, K.,Stenmark, P.,Nyman, T.,Flodin, S.,Graslund, S.,Loppnau, P.,Bianchi, V.,Nordlund, P.; Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition.; J.Biol.Chem., 282:17828-, 2007; PubMed: 17405878; DOI: 10.1074/JBC.M700917200

Experimental method

X-RAY DIFFRACTION (3.01 Å)