8AVS
| Racemic protein crystal structure of aureocin A53 from Staphylococcus aureus in the presence of citrate and acetate | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Bacteriocin aureocin A53, ... | 著者 | Lander, A.J, Baumann, P, Rizkallah, P, Jin, Y, Luk, L.Y.P. | 登録日 | 2022-08-26 | 公開日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography. Commun Chem, 6, 2023
|
|
2WEP
| |
2VSF
| Structure of XPD from Thermoplasma acidophilum | 分子名称: | CALCIUM ION, DNA REPAIR HELICASE RAD3 RELATED PROTEIN, IRON/SULFUR CLUSTER | 著者 | Kuper, J, Wolski, S.C, Truglio, J.J, Kisker, C. | 登録日 | 2008-04-23 | 公開日 | 2008-07-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal Structure of the Fes Cluster-Containing Nucleotide Excision Repair Helicase Xpd. Plos Biol., 6, 2008
|
|
2X6D
| Aurora-A bound to an inhibitor | 分子名称: | 6-BROMO-7-[4-(4-CHLOROBENZYL)PIPERAZIN-1-YL]-2-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]-3H-IMIDAZO[4,5-B]PYRIDINE, SERINE/THREONINE-PROTEIN KINASE 6, SULFATE ION | 著者 | Kosmopoulou, M, Bayliss, R. | 登録日 | 2010-02-17 | 公開日 | 2010-07-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J. Med. Chem., 53, 2010
|
|
4ISY
| |
6AK2
| Crystal structure of the syntenin PDZ1 domain in complex with the peptide inhibitor KSL-128018 | 分子名称: | Syntenin-1, peptide inhibitor KSL-128018 | 著者 | Jin, Z.Y, Park, J.H, Yun, J.H, Haugaard-Kedstrom, L.M, Lee, W.T. | 登録日 | 2018-08-29 | 公開日 | 2019-09-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.868 Å) | 主引用文献 | A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J.Med.Chem., 64, 2021
|
|
7E48
| Crystal structure of InhA in complex with 3-nitropropanoic acid inhibitor | 分子名称: | 3-NITROPROPANOIC ACID, Enoyl-[acyl-carrier-protein] reductase [NADH], GLYCEROL, ... | 著者 | Songsiriritthigul, C, Hanwarinroj, C, Suttipanta, N, Kamsri, P, Kittakoop, P, Pungpo, P. | 登録日 | 2021-02-10 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Inhibition of Mycobacterium tuberculosis InhA by 3-nitropropanoic acid. Proteins, 90, 2022
|
|
6B4W
| TTK in Complex with Inhibitor | 分子名称: | 4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide, CACODYLATE ION, Dual specificity protein kinase TTK | 著者 | Delker, S, Chamberlain, P.P. | 登録日 | 2017-09-27 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J. Med. Chem., 60, 2017
|
|
5FGK
| CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one | 分子名称: | 1,2-ETHANEDIOL, 8-[3-(3-azanyl-2~{H}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, ... | 著者 | Musil, D, Blagg, J, Mallinger, A. | 登録日 | 2015-12-20 | 公開日 | 2016-02-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J.Med.Chem., 59, 2016
|
|
3UG9
| Crystal Structure of the Closed State of Channelrhodopsin | 分子名称: | Archaeal-type opsin 1, Archaeal-type opsin 2, OLEIC ACID, ... | 著者 | Kato, H.E, Ishitani, R, Nureki, O. | 登録日 | 2011-11-02 | 公開日 | 2012-01-25 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the channelrhodopsin light-gated cation channel Nature, 482, 2012
|
|
3V15
| |
3V17
| |
3UD5
| Crystal structure of E. coli HPPK in complex with bisubstrate analogue inhibitor J1A | 分子名称: | 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[1-(2-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}ethyl)piperidin-4-yl]-5'-thioadenosine | 著者 | Shaw, G, Shi, G, Ji, X. | 登録日 | 2011-10-27 | 公開日 | 2012-01-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties. Bioorg.Med.Chem., 20, 2012
|
|
5HBH
| CDK8-CYCC IN COMPLEX WITH 5-{5-Chloro-4-[1-(2-methoxy-ethyl)-1,8-diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro-benzo[c]isothiazole 2,2-dioxide | 分子名称: | 1,2-ETHANEDIOL, 5-[5-chloranyl-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3~{H}-2,1-benzothiazole 2,2-dioxide, Cyclin-C, ... | 著者 | Musil, D, Blagg, J, Mallinger, A. | 登録日 | 2015-12-31 | 公開日 | 2016-02-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J.Med.Chem., 59, 2016
|
|
8PMX
| |
8PN0
| |
8PMZ
| |
3UDE
| Crystal structure of E. coli HPPK in complex with bisubstrate analogue inhibitor J1B | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[1-(2-{[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}ethyl)piperidin-4-yl]-5'-thioadenosine, ACETATE ION | 著者 | Shaw, G, Shi, G, Ji, X. | 登録日 | 2011-10-28 | 公開日 | 2012-01-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.881 Å) | 主引用文献 | Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties. Bioorg.Med.Chem., 20, 2012
|
|
5HBE
| CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one | 分子名称: | 1,2-ETHANEDIOL, 8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{H}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, Cyclin-C, ... | 著者 | Musil, D, Blagg, J, Mallinger, A. | 登録日 | 2015-12-31 | 公開日 | 2016-02-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J.Med.Chem., 59, 2016
|
|
8PMW
| |
8PMY
| |
3UDV
| Crystal structure of E. coli HPPK in complex with bisubstrate analogue inhibitor J1C | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[1-(2-{[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]amino}ethyl)piperidin-4-yl]-5'-thioadenosine, ACETATE ION | 著者 | Shaw, G, Shi, G, Ji, X. | 登録日 | 2011-10-28 | 公開日 | 2012-01-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties. Bioorg.Med.Chem., 20, 2012
|
|
6H1H
| Crystal structure of human Pirin in complex with compound 7 (PLX4720) | 分子名称: | 1,2-ETHANEDIOL, FE (III) ION, GLYCEROL, ... | 著者 | Ali, S, Le Bihan, Y.V, van Montfort, R.L.M. | 登録日 | 2018-07-11 | 公開日 | 2018-11-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett, 9, 2018
|
|
4ACG
| GSK3b in complex with inhibitor | 分子名称: | 2-AMINO-5-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-[4-(PYRROLIDIN-1-YLMETHYL)PYRIDIN-3-YL]PYRIDINE-3-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA | 著者 | Xue, Y, Ormo, M. | 登録日 | 2011-12-15 | 公開日 | 2012-05-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J. Med. Chem., 55, 2012
|
|
5DR5
| Crystal structure of the sclerostin-neutralizing Fab AbD09097 | 分子名称: | AbD09097 Fab heavy chain, AbD09097 Fab light chain | 著者 | Mueller, T.D, Boschert, V, Weidauer, S.E, Muth, E.M, Knappik, A, Frisch, C. | 登録日 | 2015-09-15 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Generation and Affinity Maturation of Neutralizing Anti-Sclerostin Antibodies to be published
|
|