6IMB
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![BU of 6imb by Molmil](/molmil-images/mine/6imb) | Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | 1,2-ETHANEDIOL, 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | 著者 | Zhang, X, Su, H, Xu, Y. | 登録日 | 2018-10-22 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IMI
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![BU of 6imi by Molmil](/molmil-images/mine/6imi) | Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | 1,2-ETHANEDIOL, 6-ethoxy-7-methoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | 著者 | Zhang, X, Su, H, Xu, Y. | 登録日 | 2018-10-23 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6INK
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![BU of 6ink by Molmil](/molmil-images/mine/6ink) | Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-1-[2-(1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-25 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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5JKG
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![BU of 5jkg by Molmil](/molmil-images/mine/5jkg) | |
6IND
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![BU of 6ind by Molmil](/molmil-images/mine/6ind) | Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-6,7-dimethoxy-1-[2-(6-methyl-1H-indol-3-yl)ethyl]-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-24 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.872 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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8T1L
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![BU of 8t1l by Molmil](/molmil-images/mine/8t1l) | Atomic model of the mammalian mouse Mediator complex with CKM module | 分子名称: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | 著者 | Zhao, H, Asturias, F. | 登録日 | 2023-06-02 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.83 Å) | 主引用文献 | A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. To Be Published
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5VEQ
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![BU of 5veq by Molmil](/molmil-images/mine/5veq) | MOUSE KYNURENINE AMINOTRANSFERASE III, RE-REFINEMENT OF THE PDB STRUCTURE 3E2Y | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wlodawer, A, Dauter, Z, Minor, W, Stanfield, R, Porebski, P, Jaskolski, M, Pozharski, E, Weichenberger, C.X, Rupp, B. | 登録日 | 2017-04-05 | 公開日 | 2017-11-29 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Detect, correct, retract: How to manage incorrect structural models. FEBS J., 285, 2018
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5VEP
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![BU of 5vep by Molmil](/molmil-images/mine/5vep) | MOUSE KYNURENINE AMINOTRANSFERASE III, RE-REFINEMENT OF THE PDB STRUCTURE 3E2F | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wlodawer, A, Dauter, Z, Minor, W, Stanfield, R, Porebski, P, Jaskolski, M, Pozharski, E, Weichenberger, C.X, Rupp, B. | 登録日 | 2017-04-05 | 公開日 | 2017-11-29 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Detect, correct, retract: How to manage incorrect structural models. FEBS J., 285, 2018
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3QFU
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![BU of 3qfu by Molmil](/molmil-images/mine/3qfu) | Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP | 分子名称: | 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Yan, M, Li, J.Z, Sha, B.D. | 登録日 | 2011-01-22 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
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5XFF
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![BU of 5xff by Molmil](/molmil-images/mine/5xff) | |
7SU3
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![BU of 7su3 by Molmil](/molmil-images/mine/7su3) | CryoEM structure of DNA-PK complex VII | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ... | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | 登録日 | 2021-11-16 | 公開日 | 2022-01-12 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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7SUD
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![BU of 7sud by Molmil](/molmil-images/mine/7sud) | CryoEM structure of DNA-PK complex VIII | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ... | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | 登録日 | 2021-11-16 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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7VWZ
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![BU of 7vwz by Molmil](/molmil-images/mine/7vwz) | Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Lin, W, Feng, Y, Shi, J. | 登録日 | 2021-11-12 | 公開日 | 2022-06-08 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
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5BT1
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![BU of 5bt1 by Molmil](/molmil-images/mine/5bt1) | histone chaperone Hif1 playing with histone H2A-H2B dimer | 分子名称: | HAT1-interacting factor 1, Histone H2A.1, Histone H2B.1 | 著者 | Liu, H, Zhang, M, Gao, Y, Teng, M, Niu, L. | 登録日 | 2015-06-02 | 公開日 | 2016-10-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer Structure, 24, 2016
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4IH5
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![BU of 4ih5 by Molmil](/molmil-images/mine/4ih5) | |
8DJG
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![BU of 8djg by Molmil](/molmil-images/mine/8djg) | ADGRL3-lectin domain in complex with an activating synthetic antibody fragment | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Isoform 2 of Adhesion G protein-coupled receptor L3, ... | 著者 | Kordon, S.P, Bandekar, S.J, Arac, D. | 登録日 | 2022-06-30 | 公開日 | 2023-02-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder. Nat Commun, 14, 2023
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7W5X
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![BU of 7w5x by Molmil](/molmil-images/mine/7w5x) | Cryo-EM structure of SoxS-dependent transcription activation complex with zwf promoter DNA | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Lin, W, Feng, Y, Shi, J. | 登録日 | 2021-11-30 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. Nucleic Acids Res., 50, 2022
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4M58
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![BU of 4m58 by Molmil](/molmil-images/mine/4m58) | Crystal Structure of an transition metal transporter | 分子名称: | Cobalamin biosynthesis protein CbiM, NICKEL (II) ION | 著者 | Yu, Y, Yan, C.Y, Zhang, B, Li, X.L, Gu, J.K. | 登録日 | 2013-08-08 | 公開日 | 2014-03-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters Cell Res., 24, 2014
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1XAO
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![BU of 1xao by Molmil](/molmil-images/mine/1xao) | Hsp40-Ydj1 dimerization domain | 分子名称: | Mitochondrial protein import protein MAS5 | 著者 | Wu, Y, Sha, B. | 登録日 | 2004-08-26 | 公開日 | 2005-05-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | The crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 reveals novel dimerization motif for Hsp40 J.Mol.Biol., 346, 2005
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5CFF
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![BU of 5cff by Molmil](/molmil-images/mine/5cff) | |
1XZY
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![BU of 1xzy by Molmil](/molmil-images/mine/1xzy) | Solution structure of the P30-trans form of Alpha Hemoglobin Stabilizing Protein (AHSP) | 分子名称: | Alpha-hemoglobin stabilizing protein | 著者 | Gell, D.A, Feng, L, Zhou, S, Kong, Y, Lee, C, Weiss, M.J, Shi, Y, Mackay, J.P. | 登録日 | 2004-11-12 | 公開日 | 2004-12-21 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin Cell(Cambridge,Mass.), 119, 2004
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7TTZ
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![BU of 7ttz by Molmil](/molmil-images/mine/7ttz) | Heterodimeric IgA Fc in complex with Staphylococcus aureus protein SSL7 | 分子名称: | 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Boulanger, M.J, Verstraete, M, Heinkel, F, Escobar, E, Dixit, S, Von Kreudenstein, T.S. | 登録日 | 2022-02-02 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics. Mabs, 14, 2022
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7TYQ
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![BU of 7tyq by Molmil](/molmil-images/mine/7tyq) | TEAD2 bound to Compound 1 | 分子名称: | Transcriptional enhancer factor TEF-4, ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate | 著者 | Noland, C.L, Fong, R. | 登録日 | 2022-02-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an
expanded Hippo dependent landscape in cancers To Be Published
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7TYU
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![BU of 7tyu by Molmil](/molmil-images/mine/7tyu) | TEAD2 bound to Compound 2 | 分子名称: | (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4 | 著者 | Noland, C.L, Fong, R. | 登録日 | 2022-02-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an
expanded Hippo dependent landscape in cancers To Be Published
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7TYP
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![BU of 7typ by Molmil](/molmil-images/mine/7typ) | TEAD2 bound to GNE-7883 | 分子名称: | (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4 | 著者 | Noland, C.L, Fong, R. | 登録日 | 2022-02-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an
expanded Hippo dependent landscape in cancers To Be Published
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