7TYP

TEAD2 bound to GNE-7883

Summary for 7TYP

• Entry DOI: 10.2210/pdb7typ/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, ... (4 entities in total)
• Functional Keywords: small molecule ppi inhibitor complex, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 53724.82

Authors

Noland, C.L.,Fong, R. (deposition date: 2022-02-14, release date: 2023-05-03, Last modification date: 2023-10-25)

• Primary citation: Hagenbeek, T.J.,Zbieg, J.R.,Noland, C.L.,Yao, X.,Schmidt, S.,Clausen, S.,Steffek, M.,Lee, W.,Beroza, P.,Martin, S.,Lin, E.,Fong, R.,Di Lello, P.,Kubala, M.H.,Lacap, J.A.,Yang, M.N.Y.,Maddalo, D.,Lau, J.T.,An, L.,Levy, E.,Lorenzo, M.N.,Lee, H.J.,Pham, T.H.,Modrusan, Z.,Zang, R.,Chen, Y.C.,Li, J.,Hafner, M.,Chang, M.T.,Crawford, J.J.,Dey, A.; Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)