7TTZ

Heterodimeric IgA Fc in complex with Staphylococcus aureus protein SSL7

Summary for 7TTZ

• Entry DOI: 10.2210/pdb7ttz/pdb
• Descriptor: IgA Fc, Superantigen-like protein SSL7, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: iga, heterodimer, antibody fc, antibody engineering, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 96213.00

Authors

Boulanger, M.J.,Verstraete, M.,Heinkel, F.,Escobar, E.,Dixit, S.,Von Kreudenstein, T.S. (deposition date: 2022-02-02, release date: 2023-02-01, Last modification date: 2024-11-06)

Primary citation

Heinkel, F.,Verstraete, M.M.,Cao, S.,Li, J.,Farber, P.,Stangle, E.,Silva-Moreno, B.,Peng, F.,Dixit, S.,Boulanger, M.J.,Spreter Von Kreudenstein, T.,Escobar-Cabrera, E.
Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics.
Mabs, 14:2141637-2141637, 2022

PubMed Abstract: CE-SDS: capillary electrophoresis sodium dodecyl sulfate; DSC: differential scanning calorimetry; FACS: fluorescence-activated cell sorting; FSA: full-sized antibody; Her2: human epidermal growth factor receptor 2; MFI: mean fluorescent intensity; OAA: one-armed antibody; PBS: phosphate-buffered saline; PDB: Protein Data Bank; SEC: size-exclusion chromatography; prepSEC (preparative SEC); RMSD: root-mean-square deviation; RU: resonance units; SPR: surface plasmon resonance; TAA: tumor-associated antigen; WT: wild-type.

PubMed: 36343329
DOI: 10.1080/19420862.2022.2141637

Experimental method

X-RAY DIFFRACTION (2.35 Å)