8I4C
 
 | | Cryo-EM structure of U46619-bound ABCC4 | | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, ATP-binding cassette sub-family C member 4 | | 著者 | Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q. | | 登録日 | 2023-01-19 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
|
|
8J3Z
 | | Cryo-EM structure of ATP-U46619-bound ABCC4 | | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, ... | | 著者 | Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q. | | 登録日 | 2023-04-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
|
|
8J3W
 | | Cryo-EM structure of aspirin-bound ABCC4 | | 分子名称: | 2-(ACETYLOXY)BENZOIC ACID, ATP-binding cassette sub-family C member 4 | | 著者 | Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q. | | 登録日 | 2023-04-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
|
|
6ALJ
 | | ALDH1A2 liganded with NAD and compound WIN18,446 | | 分子名称: | Aldehyde dehydrogenase 1A2, N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide), NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Chen, Y, Zhu, J.-Y, Schonbrunn, E. | | 登録日 | 2017-08-08 | | 公開日 | 2018-01-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors.
ACS Chem. Biol., 13, 2018
|
|
6B5H
 | |
6B5G
 | |
6B5I
 | |
7E34
 | | Crystal structure of SUN1-Speedy A-CDK2 | | 分子名称: | Cyclin-dependent kinase 2, GLYCEROL, SUN domain-containing protein 1, ... | | 著者 | Chen, Y, Huang, C, Wu, J, Lei, M. | | 登録日 | 2021-02-08 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Nat Commun, 12, 2021
|
|
5YPS
 | | The structural basis of histone chaperoneVps75 | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Chen, Y, Zhang, Y, Dou, Y, Wang, M, Xu, S, Jiang, H, Limper, A, Su, D. | | 登録日 | 2017-11-03 | | 公開日 | 2018-11-07 | | 最終更新日 | 2020-06-10 | | 実験手法 | X-RAY DIFFRACTION (2.097 Å) | | 主引用文献 | Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inPneumocystis carinii.
Signal Transduct Target Ther, 4, 2019
|
|
8UAP
 | |
8UAQ
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL018-21 | | 分子名称: | (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 | | 著者 | Chen, Y, Tesmer, J.J.G. | | 登録日 | 2023-09-21 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.
Eur.J.Med.Chem., 264, 2023
|
|
5ZB5
 | | The structural basis of histone chaperoneVps75 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NAP family histone chaperone vps75 | | 著者 | Chen, Y, Zhang, Y, Dou, Y, Wang, M, Xu, S, Jiang, H, Limper, A, Su, D. | | 登録日 | 2018-02-09 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | | 主引用文献 | Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inPneumocystis carinii.
Signal Transduct Target Ther, 4, 2019
|
|
6LQX
 | | Crystal structure of the CBP bromodomain in complex with small molecule LC-CPin7 | | 分子名称: | (1~{S},6~{R})-6-[(1-methoxycarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid, CREB-binding protein, SODIUM ION | | 著者 | Chen, Y, Zhang, F, Sun, Z, Bi, X, Luo, C. | | 登録日 | 2020-01-14 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Design, synthesis and biological evaluation of novel small molecule inhibitor of the CBP bromodomain with possible anti-leukemia effects
To Be Published
|
|
6JTK
 | | Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-trifluoroacetyl-D-glucosamine | | 分子名称: | 2,2,2-tris(fluoranyl)-N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide, Beta-hexosaminidase | | 著者 | Chen, Y. | | 登録日 | 2019-04-11 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-trifluoroacetyl-D-glucosamine
To Be Published
|
|
6JTI
 | |
6JTL
 | |
7DDC
 | | Crystal structure of SARS-CoV-2 main protease in complex with Tafenoquine | | 分子名称: | 3C-like proteinase, Tafenoquine | | 著者 | Chen, Y, Wang, Y.C, Yang, C.S, Hung, M.C. | | 登録日 | 2020-10-28 | | 公開日 | 2021-11-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | | 主引用文献 | Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2.
J.Biol.Chem., 298, 2022
|
|
8JIG
 | | A Novel UHRF1-Targeted Compound | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, N-[2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]-N'-oxidanyl-octanediamide | | 著者 | Chen, Y, Jiang, L. | | 登録日 | 2023-05-26 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A Novel UHRF1-Targeted Compound
To Be Published
|
|
7WVD
 | | Crystal structure of H14 complexed with SIA28 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of SIA28, ... | | 著者 | Chen, Y, Qi, J, Gao, G.F. | | 登録日 | 2022-02-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | | 主引用文献 | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.
Nat Commun, 13, 2022
|
|
7WVI
 | | Crystal structure of SIA28 | | 分子名称: | Heavy chain of SIA28, Light chain of SIA28 | | 著者 | Chen, Y, Qi, J, Gao, G.F. | | 登録日 | 2022-02-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.
Nat Commun, 13, 2022
|
|
7WVG
 | | Crystal structure of H18 complexed with SIA28 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of SIA28, ... | | 著者 | Chen, Y, Qi, J, Gao, G.F. | | 登録日 | 2022-02-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.
Nat Commun, 13, 2022
|
|
5X8F
 | |
5X8G
 | |
7WVB
 | | Human Fructose-1,6-bisphosphatase 1 mutant R50A in APO R-state | | 分子名称: | Fructose-1,6-bisphosphatase 1 | | 著者 | Chen, Y, Zhang, J, Li, C, Cao, Y. | | 登録日 | 2022-02-10 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Human Fructose-1,6-bisphosphatase 1 mutant R50A in APO R-state
To Be Published
|
|
7UL1
 | | Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing IGHV3-53-encoded antibody EH3 isolated from a nonvaccinated pediatric patient | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of EH3, Light chain of EH3, ... | | 著者 | Chen, Y, Tolbert, W.D, Pazgier, M. | | 登録日 | 2022-04-03 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.
Iscience, 26, 2023
|
|
